Fig. 1 · Structure
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S-5751
PGD2 Antagonist
S-5751 is an orally active antagonist of the prostaglandin D2 (PGD2) receptor. It effectively inhibits cAMP generation in platelet-rich plasma induced by PGD2 with an IC50 of 0.12 μM. S-5751 demonstrates anti-inflammatory properties and is particularly useful in asthma research, providing insights into the modulation of inflammatory pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 209268-36-0 |
| Applications | PGD2 Antagonist |
| Formula | C25H31NO4S |
| Molecular Weight | 441.58 |
| SMILES | O=C(C(C1=C2)=CSC1=CC=C2O)N[C@H]3[C@@]4([H])C(C)([C@](C[C@@H]3C/C=C\CCCC(O)=O)([H])C4)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.