Catalog No.
Product Name
Application
Product Information
Citations
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κ-opioid agonists
ICI-204448 free acid is a potent κ-opioid agonist that demonstrates limited central nervous system penetration. It effectively displaces the binding of the kappa-opioid ligand ^3H-bremazocine from guinea pig cerebellum membranes, making it a valuable tool for exploring κ-opioid receptor interactions. This compound is useful in research applications focused on pain modulation, neuropsychiatric disorders, and the pharmacological profiling of κ-opioid receptors. -
Opioid Receptor Modulator
Opioid Receptor Modulator 1 functions as a selective modulator of opioid receptors, primarily influencing mu and delta subtypes. This compound demonstrates significant biological activity in pain relief and modulation of reward pathways, making it a valuable tool for research into analgesics and addiction therapies. Its applications extend to studies on the pharmacological effects of opioid modulation in various neurological conditions. -
Opioid Receptor Control
Isopaynantheine is an alkaloid that primarily targets opioid receptors. It demonstrates significant antinociceptive activity, making it valuable for pain management studies. Researchers utilize Isopaynantheine to explore opioid receptor modulation and its therapeutic potential in pain-related research. -
Opioid Receptor agonist
DuP 747 is a selective agonist of the kappa-opioid receptor. It exhibits analgesic properties, making it a valuable compound for research focused on pain management and opioid receptor pharmacology. This reagent is useful in exploring the physiological and therapeutic roles of kappa-opioid receptors in various biological contexts. -
kappa-opioid receptor Agonist
22-Thiocyanatosalvinorin A is a potent and selective kappa-opioid receptor agonist, exhibiting an EC50 of 0.077 nM. This compound demonstrates significant biological activity through its interaction with the kappa-opioid receptor, facilitating applications in pain management and neuropharmacological research. Its specificity makes it a valuable tool for studying kappa-opioid receptor signaling pathways and potential therapeutic effects in various neurological conditions. -
Opioid Receptor Agonist
7-PET is a potent μ-opioid receptor agonist, demonstrating significant efficacy in activating opioid signaling pathways. This compound is primarily utilized in research focused on psychiatric disorders, aiding in the exploration of pain modulation, addiction mechanisms, and potential therapeutic interventions for mood disorders. Its selective action makes it a valuable tool for understanding the complex roles of opioid receptors in the central nervous system. -
Opioid Receptor Antagonist
Naltrindole 5′-isothiocyanate (5'-NTII) is an opioid receptor antagonist with a primary mechanism of non-selective antagonism at delta opioid receptors. This compound effectively inhibits the analgesic effects produced by DSLET, while leaving the analgesic effects mediated by DPDPE unaffected. Naltrindole 5′-isothiocyanate is valuable in research applications focused on understanding the therapeutic potential and mechanisms of opioid receptor modulation. -
Opioid Compound
Bromadoline is a utopioid that primarily targets opioid receptors, exhibiting significant antinociceptive activity in rodent models. This compound is utilized in research to explore pain management mechanisms and the development of novel analgesics. Its specific receptor interactions make it a valuable tool for studying the pharmacological effects of opioids in various biological systems. -
Opioid Receptor
Volazocine is an opioid benzomorphane derivative that selectively targets opioid receptors. This compound exhibits significant analgesic activity, making it a valuable research tool for studying pain mechanisms and opioid pharmacology. It is particularly useful in evaluating the efficacy and safety profiles of new analgesic therapies. -
Opioid Receptor
1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid is a selective modulator of opioid receptors. This compound exhibits significant affinity for cannabinoid receptor sites and shows potential in studying the therapeutic effects of cannabinoid modulation. It is primarily used in research exploring the pharmacological effects of synthetic cannabinoids and their metabolites. -
Opioid Antagonist
RX809055AX is a potent long-acting opioid antagonist that demonstrates selectivity towards mu and delta opioid receptors. This compound effectively inhibits opioid-induced signaling, making it valuable for research applications in pain management and addiction studies. Its extended duration of action offers a consistent approach to investigating opioid receptor activity and its physiological implications. -
Opioid Receptor
Piperidylthiambutene hydrochloride is an opioid receptor agonist that exhibits significant analgesic activity in various animal models. This compound is primarily utilized in research focused on pain management and the study of opioid receptor signaling pathways. Its utility in pharmacological studies makes it a valuable reagent for investigating opioid-related mechanisms and potential therapeutic applications. -
δ-Opioid Receptor Agonist
AZ 12488024 is a potent δ-opioid receptor agonist that acts as a derivative of SNC80. This compound exhibits significant biological activity related to mood regulation and is primarily utilized in research focused on major depressive disorder. Its specific mechanism of action at the δ-opioid receptor makes it a valuable tool for studying opioid-related pathways and their implications in neuropsychiatric conditions. -
κ-Opioid Receptor Agonist
R-84760 is a selective κ-opioid receptor agonist that exhibits significant antinociceptive effects. This compound is primarily utilized in pain research, offering insights into the modulation of pain pathways and potential therapeutic applications in analgesia. Its specificity for the κ-opioid receptor makes it a valuable tool for understanding opioid receptor pharmacology and the development of new pain management strategies. -
Opioid Compound
N-Phenethylnoroxymorphone is an opioid compound that acts primarily on the μ-opioid receptor, enhancing the analgesic effects of morphine. This compound has demonstrated increased morphine-induced analgesia in preclinical models, particularly in rats. Its potent efficacy makes it suitable for research applications in the study of pain mechanisms and neurological disorders. -
Opioid Compound
Dipyanone hydrochloride is an opioid compound that interacts with the mu-opioid receptor, leading to analgesic effects. This reagent is primarily used in research related to pain management and opioid receptor studies. Its structural similarity to other opioids makes it a valuable tool for investigating opioid mechanisms and exploring potential therapeutic applications. -
μ-Opioid Receptor Agonist
U-48520 is a μ-opioid receptor agonist, demonstrating an EC50 value of 1561 nM. This compound is primarily utilized in research applications focused on pain management and opioid signaling pathways. Its activity at the μ-opioid receptor underscores its potential for studying analgesic effects and receptor pharmacodynamics in cellular and in vivo models. -
Opioid Receptor Antagonist
JTC-801 free base is a selective antagonist of the opioid receptor-like 1 (ORL1) receptor, exhibiting a binding affinity with a Ki value of 8.2 nM. This compound effectively modulates ORL1 receptor signaling, making it a valuable tool for research into pain modulation and opioid receptor pharmacology. Its application extends toward studying the role of ORL1 in various physiological and pathological processes. -
Opioid Compound
Bromadol is a synthetic opioid that acts as a potent agonist at the mu-opioid receptor. It exhibits significant analgesic properties, making it valuable for pain research and pharmacological studies. Bromadol's unique chemical structure offers potential insights into opioid receptor mechanisms and the development of novel analgesics. -
Opioid Compounds
AH 7563 is an opioid compound that demonstrates significant analgesic properties. In in vivo assays, it exhibited an ED50 of 15.3 mg/kg when administered orally and 15.5 mg/kg via subcutaneous injection, as measured in the phenylquinone and hot plate tests in mice. This compound is suitable for research applications focusing on pain management and opioid receptor studies. -
Opioid Compound
N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride is an opioid compound that acts primarily on the opioid receptors in the central nervous system. This compound demonstrates significant analgesic properties and is useful in studies exploring pain relief mechanisms. It is applicable in research focusing on opioid receptor modulation and the development of new therapeutic agents for pain management. -
Opioid Compound
3,4-Ethylenedioxy U-51754 hydrochloride is an opioid compound that acts primarily on the opioid receptors in the central nervous system. It exhibits analgesic properties and is utilized in research focused on pain modulation and the development of new analgesics. This reagent is essential for studies investigating the structure-activity relationships of opioid analogs and their potential therapeutic effects. -
κ-opioid receptor Antagonist
5′-Guanidinonaltrindole is a selective antagonist of the κ-opioid receptor, inhibiting its activation. This compound plays a crucial role in research related to pain modulation, stress response, and addiction mechanisms. It is instrumental in studying the physiological effects and potential therapeutic applications of kappa opioid receptor modulation in various biological systems. -
Opioid Compound
3,4-Difluoro-N-desmethyl U-47700 hydrochloride is an opioid compound that acts on the μ-opioid receptor, demonstrating potent analgesic properties. This reagent is primarily utilized in research focused on pain management and addiction studies, contributing to a deeper understanding of opioid receptor activities and their therapeutic implications. Its unique fluorinated structure enhances its pharmacological profile, making it a valuable tool for scientific investigations into opioid-related pathways. -
Opioid Analog
Chlorphine is a halogenated opioid analog that primarily targets opioid receptors in the central nervous system. This compound exhibits significant neuroactive properties, making it valuable for studying pain modulation and addiction mechanisms. Its unique structure allows for exploration of receptor interactions and the development of potential therapeutic agents in pain management and opioid research. -
Opioid Receptor
3,4-Difluoro U-49900 hydrochloride is a selective opioid receptor agonist, primarily targeting the mu-opioid receptor. This compound exhibits strong analgesic properties and is utilized in research to investigate opioid signaling pathways and pain management mechanisms. Its potential applications include studies on addiction, analgesia, and opioid receptor pharmacology. -
Opioid Compound
Desmethylmoramide is an opioid compound that exerts its effects primarily through interaction with opioid receptors, facilitating pain relief. This compound demonstrates notable analgesic activity in rodent models, making it a valuable tool for research into pain management and opioid pharmacology. Its structural similarity to established opioids may provide insights into opioid receptor function and the development of new analgesic therapies. -
Opioid Receptor
DuP 747 hydrochloride is a selective agonist of the kappa-opioid receptor, primarily involved in analgesic activity. Studies indicate its administration can yield variable responses, with a lesser agonistic profile when given subcutaneously compared to intraperitoneal or oral routes. Notably, the 5-hydroxy-desmethoxy metabolite of DuP 747 predominantly influences behaviors associated with the saline-appropriate lever. These findings highlight the potential role of its metabolites in mediating responses similar to other kappa-opioid receptor ligands, enabling further exploration in the field of pain management and receptor pharmacology. -
Opioid Compound
Ortho-methyl 4-anilino-1-boc-piperidine is an opioid compound that serves as a crucial precursor in synthetic pathways for the development of opioid receptor ligands. This reagent is valuable in chemical research aimed at designing and optimizing new analgesics with potential therapeutic applications in pain management and addiction treatment. Its structural features allow for modifications that can lead to enhanced receptor selectivity and activity. -
Opioid Receptor
CP-866,087 is a potent and selective μ-opioid receptor antagonist. It effectively inhibits opioid effects and has demonstrated promising preclinical efficacy in models related to alcohol consumption. Additionally, CP-866,087 has been utilized in research investigating female sexual dysfunction. -
Opioid Compound
Orphine is an opioid compound that primarily targets the opioid receptors in the central nervous system. It has been shown to enhance antinociceptive effects in murine models, with these effects being reversed by Naloxone, indicating its potential utility in pain management research. This compound is valuable for studying opioid mechanisms and developing analgesic therapies. -
Opioid Compound
AH 8529 is an orally active opioid compound that primarily targets opioid receptors. It exhibits potent analgesic activity, making it valuable for pain management research. Its unique pharmacological profile enables investigations into opioid receptor signaling and the development of novel pain therapeutics. -
Opioid Compound
N-(1-Benzyl-4-piperidyl)-N-benzylpropanamide hydrochloride is an opioid compound that interacts with opioid receptors, primarily influencing the mu-opioid receptor pathway. This compound exhibits significant analgesic properties, making it a valuable tool for research focused on pain management and opioid receptor characterization. Its unique structure provides a basis for exploring potential leads in the development of novel analgesics. -
Opioid Compound
2,4-Difluoro U-48800 hydrochloride is a selective u-opioid receptor agonist. It exhibits significant analgesic properties, making it valuable in pain management research. This compound is useful for studying opioid receptor interactions and the development of novel analgesics in medicinal chemistry. -
Opioid Compound
Methylketobemidone is an opioid receptor agonist that interacts primarily with the mu-opioid receptor. This compound exhibits significant analgesic activity, making it a valuable tool for investigating pain pathways and developing pain management therapies. Its structural similarity to existing opioids allows for comparative studies in opioid receptor pharmacology and the evaluation of potential side effects and efficacy in preclinical research. -
Opioid Compound
3,4-Difluoro U-50488 hydrochloride is a selective kappa-opioid receptor agonist. This compound exhibits potent analgesic activity and has been utilized in research to explore the neuropharmacological effects of kappa-opioid receptor modulation. Its unique structural modifications enhance specificity, making it a valuable tool for investigating pain pathways and opioid signaling mechanisms in various biological contexts. -
Opioid Compound
2-Naphthyl U-47700 is a selective μ-opioid receptor agonist. It demonstrates potent analgesic activity, making it an important compound for research into pain management and opioid receptor functionality. This reagent is useful for exploring the pharmacological effects of opioids and investigating potential therapeutic applications in pain relief. -
Opioid Compounds
AH 8507 is an analog of AH 7563, belonging to the class of opioid compounds. Despite its structural similarity, AH 8507 displays minimal analgesic effects in animal models, with ED50 values exceeding 100 mg/kg in both the phenylquinone and hot plate tests. This compound is primarily utilized in research to further understand the mechanisms of opioid activity and to explore the structure-activity relationship within opioid analogs. -
Opioid Compound
3,4-Difluoro propyl U-47700 is an opioid compound that acts as a selective agonist at the mu-opioid receptor. This compound exhibits potent analgesic properties and is primarily utilized in pharmacological research related to pain management and opioid receptor studies. Its structural modifications enhance its biological activity, making it a valuable tool for understanding opioid mechanisms and potential therapeutic applications. -
Opioid Receptor Modulator
Samidorphan hydrochloride is an opioid receptor modulator with significant binding affinity for μ-opioid, κ-opioid, and δ-opioid receptors. It functions primarily as an antagonist at μ-opioid receptors while acting as a partial agonist at κ- and δ-opioid receptors. This unique profile enables Samidorphan hydrochloride to modulate opioid activity, making it a valuable tool in research focused on depression and other mood disorders. Its ability to improve behavioral outcomes in depressed animal models highlights its potential applications in neuropharmacology. -
Opioid Compound
3,4-Difluoro isopropyl U-47700 is a synthetic opioid compound that acts primarily on the mu-opioid receptor. It exhibits potent analgesic effects, making it relevant for research into pain management and opioid receptor pharmacology. Its unique structure allows for the exploration of opioid effects as well as potential applications in the study of drug interactions and addiction mechanisms. -
Opioid Compound
U-49900 is a u-opioid receptor agonist that demonstrates significant analgesic properties. Its primary mechanism involves modulating pain responses by activating the u-opioid receptor, which is integral in the management of pain signaling pathways. This compound is commonly used in pharmacological studies focusing on pain relief, opioid receptor interactions, and the development of novel analgesics. -
Opioid Receptor Agonist
Salvinorin A carbamate is a potent κ-opioid receptor agonist, exhibiting an EC50 value of 6.2 nM and a Ki of 3.2 nM. This compound demonstrates significant biological activity in modulating pain and has potential applications in the study of addiction and mood disorders. Its unique pharmacological profile makes it a valuable tool for research in opioid receptor signaling and therapeutic development. -
Opioid Compound
Bipiperidinyl 4-ANPP is an opioid compound that interacts primarily with the mu-opioid receptor. This compound demonstrates significant analgesic properties and is utilized in research focused on pain management and opioid receptor pharmacology. Its structural similarity to known opioids positions it as a valuable tool for investigating the mechanisms underlying opioid action and potential therapeutic applications in chronic pain and addiction studies. -
μ-Opioid Receptor Agonist
Endomorphin 2 is a high-affinity agonist of the μ-opioid receptor, exhibiting selectivity and potency in targeting this pathway. It also shows moderate affinity for kappa3 binding sites, with a Ki value ranging from 20 to 30 nM. This compound is valuable for research in pain management, neurobiology, and the pharmacological characterization of opioid receptors. Its unique properties make it suitable for studies focused on opioid signaling and potential therapeutic applications in pain relief. -
Opioid Receptor Agonist
AWL 60 is an opioid receptor agonist that also exhibits properties as a substance P (SP) antagonist. This compound has been shown to antagonize SP agonists in vitro, as well as attenuate hypotension induced by SP agonists in vivo. AWL 60 is relevant for research applications focused on pain modulation, opioid receptor signaling, and neuroinflammatory responses. -
Antispasmodic Opioid Alkaloid
Pargeverine hydrochloride is an antispasmodic opioid alkaloid that primarily targets muscarinic cholinergic receptors, exhibiting a moderate and non-selective blockade. This compound is utilized in research to investigate mechanisms underlying painful spasms and their management. Its application in understanding muscle contraction and relaxation makes it a valuable reagent in pharmacological studies.
