Tubulysin G is a potent anti-microtubule toxin that targets microtubule dynamics by inhibiting tubulin polymerization. Derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin G exhibits significant cytotoxicity towards mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce apoptosis and cause cell cycle arrest makes it a valuable reagent for research applications in cancer biology and cell death mechanisms.
Tubulysin G is a potent anti-microtubule toxin that targets microtubule dynamics by inhibiting tubulin polymerization. Derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin G exhibits significant cytotoxicity towards mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce apoptosis and cause cell cycle arrest makes it a valuable reagent for research applications in cancer biology and cell death mechanisms.
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