Tubulysin F is a potent apoptosis inducer that functions as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits strong cytotoxic activity across various mammalian cell types, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin F effectively leads to cell cycle arrest and subsequent apoptosis, making it a valuable reagent for research in cancer biology and drug resistance mechanisms.
Tubulysin F is a potent apoptosis inducer that functions as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits strong cytotoxic activity across various mammalian cell types, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. By inhibiting microtubule and tubulin polymerization, Tubulysin F effectively leads to cell cycle arrest and subsequent apoptosis, making it a valuable reagent for research in cancer biology and drug resistance mechanisms.
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