27-Methyl withaferin A

Catalog No.: A33153
Apoptosis Inducer
27-Methyl withaferin A is an apoptosis inducer that exhibits significant anticancer properties. This compound demonstrates potent antiproliferative effects against various human tumor cell lines, including HeLa, A-549, and MCF-7, with respective IC50 values of 3.2 μM, 4.2 μM, and 1.4 μM. Its ability to promote programmed cell death makes it a valuable tool for research in cancer biology and therapeutic development.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description27-Methyl withaferin A is an apoptosis inducer that exhibits significant anticancer properties. This compound demonstrates potent antiproliferative effects against various human tumor cell lines, including HeLa, A-549, and MCF-7, with respective IC50 values of 3.2 μM, 4.2 μM, and 1.4 μM. Its ability to promote programmed cell death makes it a valuable tool for research in cancer biology and therapeutic development.
Product Information
Catalog NumA33153
FormulaC29H40O6
Molecular Weight484.62
CAS Number1777780-93-4
SMILESC[C@]12[C@@]3([C@H](C=CC2=O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)COC)C)C)([H])O3
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