Apoptosis Inducer 24 targets the apoptosis pathway to inhibit proliferation in gastric cancer cells, with an IC50 ranging from 1.2 to 4.8 μM. This compound causes cell cycle arrest at the G2/M phase, induces apoptosis in the BGC-823 cell line, and disrupts mitochondrial function. Additionally, Apoptosis Inducer 24 demonstrates significant antitumor efficacy in murine models, exhibiting a favorable safety profile with an LD50 of 91.2 mg/kg.
Apoptosis Inducer 24 targets the apoptosis pathway to inhibit proliferation in gastric cancer cells, with an IC50 ranging from 1.2 to 4.8 μM. This compound causes cell cycle arrest at the G2/M phase, induces apoptosis in the BGC-823 cell line, and disrupts mitochondrial function. Additionally, Apoptosis Inducer 24 demonstrates significant antitumor efficacy in murine models, exhibiting a favorable safety profile with an LD50 of 91.2 mg/kg.
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