cpm-1285

Name: cpm-1285
Brand: Adooq Bioscience
SKU: A32163
Rating: 5 (288 reviews)

Catalog No.: A32163

Apoptosis Inducer

cpm-1285 is an apoptosis inducer that functionally inhibits intracellular Bcl-2 and related death antagonists. It demonstrates a strong binding affinity to Bcl-2, with an IC50 value of 130 nM. In preclinical studies, cpm-1285 effectively reduces tumor burden in murine models, making it a valuable tool for research on cancer therapies and the mechanisms of programmed cell death.

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Biological Activity

Description	cpm-1285 is an apoptosis inducer that functionally inhibits intracellular Bcl-2 and related death antagonists. It demonstrates a strong binding affinity to Bcl-2, with an IC50 value of 130 nM. In preclinical studies, cpm-1285 effectively reduces tumor burden in murine models, making it a valuable tool for research on cancer therapies and the mechanisms of programmed cell death.

Product Information

Catalog Num	A32163
Formula	C153H240N44O42S
Molecular Weight	3399.88
CAS Number	300349-97-7
Sequence	{Decanoyl}-Lys-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Glu-Phe-Glu-Gly-Ser-Phe-Lys-Gly-Leu
Sequence shortening	{Decanoyl}-KNLWAAQRYGRELRRMSDEFEGSFKGL
SMILES	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCC)=O)CCCCN)=O)CC(N)=O)=O)CC(C)C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCCCN)=O)=O)CO)=O)=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CO)=O)CCSC)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)=O)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)C)=O)C)=O)C=4C=5C(NC4)=CC=CC5

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