Anticancer agent 136 is a C17-triazole analogue of Geldanamycin that functions as an apoptosis inducer by targeting Hsp90. It demonstrates an IC50 of 3.38 μM in human dermal fibroblasts (HDF) and a dissociation constant (Kd) of 3.86 μM for Hsp90. This compound is useful for research investigating apoptosis pathways and the therapeutic potential of Hsp90 inhibition in cancer treatment.
Anticancer agent 136 is a C17-triazole analogue of Geldanamycin that functions as an apoptosis inducer by targeting Hsp90. It demonstrates an IC50 of 3.38 μM in human dermal fibroblasts (HDF) and a dissociation constant (Kd) of 3.86 μM for Hsp90. This compound is useful for research investigating apoptosis pathways and the therapeutic potential of Hsp90 inhibition in cancer treatment.
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