Apoptosis Inducer 36 is a potent apoptosis inducer targeting leukemia cells. It demonstrates significant anti-leukemic activity by reducing leukemia stem cells and promoting differentiation. This compound inhibits the proliferation of acute myeloid leukemia (AML) cells, causes cell cycle arrest at the G1 phase, and stimulates PANoptosis, encompassing apoptosis, pyroptosis, and necrosis. A prodrug form of Apoptosis Inducer 36 shows orally active antitumor efficacy in mouse models, making it a valuable tool for research in cancer therapeutics.
Apoptosis Inducer 36 is a potent apoptosis inducer targeting leukemia cells. It demonstrates significant anti-leukemic activity by reducing leukemia stem cells and promoting differentiation. This compound inhibits the proliferation of acute myeloid leukemia (AML) cells, causes cell cycle arrest at the G1 phase, and stimulates PANoptosis, encompassing apoptosis, pyroptosis, and necrosis. A prodrug form of Apoptosis Inducer 36 shows orally active antitumor efficacy in mouse models, making it a valuable tool for research in cancer therapeutics.
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