Apoptosis inducer 41

Catalog No.: A32360
Apoptosis Inducer
Apoptosis Inducer 41 targets the mitochondrial pathway to trigger apoptosis in cancer cells. It displays potent inhibitory effects on MCF-7 cells, with an IC50 of 6.2 μM, and effectively induces cell cycle arrest in the G2/M phase. Additionally, Apoptosis Inducer 41 increases reactive oxygen species (ROS) accumulation and causes depolarization of the mitochondrial membrane potential. This compound is suitable for research focused on breast cancer and the mechanisms of programmed cell death.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionApoptosis Inducer 41 targets the mitochondrial pathway to trigger apoptosis in cancer cells. It displays potent inhibitory effects on MCF-7 cells, with an IC50 of 6.2 μM, and effectively induces cell cycle arrest in the G2/M phase. Additionally, Apoptosis Inducer 41 increases reactive oxygen species (ROS) accumulation and causes depolarization of the mitochondrial membrane potential. This compound is suitable for research focused on breast cancer and the mechanisms of programmed cell death.
Product Information
Catalog NumA32360
FormulaC39H53BrN4O4
Molecular Weight721.77
CAS Number3085940-57-1
SMILESC[C@@]12[C@](C[C@@]3([H])[C@]2([H])[C@@H]([C@H](O3)CC[C@@H](C)C(NCC4=CN(N=N4)CC5=CC=C(C=C5)Br)=O)C)([H])[C@@]6([H])[C@]([C@@]7(C(C[C@H](CC7)OC(C)=O)=CC6)C)([H])CC1
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