Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
GYKI-16084 is an endogenous metabolite that can be isolated from canine and rodent urine. This compound exhibits potential relevance in studying benign prostatic hyperplasia, contributing to our understanding of urological health and disorders. Its utility in research makes it a valuable tool for exploring mechanisms underlying prostate-related conditions. -
Endogenous Metabolite
A 854777 is a homologous piperazine derivative that targets endogenous metabolites, exhibiting notable anti-inflammatory activity. This compound possesses non-classical immunosuppressive properties, making it valuable for studies focused on modulating immune responses. Its applications include research into diseases characterized by inflammation, providing insights into potential therapeutic interventions. -
Endogenous Metabolite
9-cis-Vitamin A palmitate is an endogenous metabolite and a 9-cis isomer derived from vitamin A palmitate, commonly found in dietary sources such as corn flakes. This compound exhibits approximately 26% of the biological activity compared to all-trans-vitamin A palmitate, the predominant and most active form of vitamin A. It serves as a valuable reagent for research focused on vitamin A metabolism, retinoid signaling pathways, and the development of therapies targeting retinoid-related disorders. -
Endogenous Metabolite
OMDM-3 is a selective inhibitor of anandamide cellular uptake (ACU), exhibiting a Ki value of 16.6 μM. This compound is metabolically stable, making it suitable for studies investigating the role of anandamide in cannabinoid signaling and endocannabinoid system modulation. OMDM-3 can be utilized in research applications focused on pain management, neuroprotection, and the exploration of lipid signaling pathways. -
Endogenous Metabolite
DF 461 is a selective sterol synthase inhibitor that effectively impairs cholesterol biosynthesis. Demonstrating high specificity for liver tissue, DF 461 significantly reduces cholesterol synthesis in rat liver models. This compound has also been shown to lower plasma lipid levels in repeated dosing studies in non-rodent species, making it valuable for research applications related to lipid metabolism and cardiovascular health. -
Endogenous Metabolite
UCM765 is a selective ligand for the MT2-type melatonin receptor, exhibiting hypnotic, analgesic, and anxiolytic activities. Its partial agonist properties make it a valuable compound for pharmacological research. Structural modifications of UCM765 can enhance its water solubility and metabolic stability, potentially increasing its bioavailability. The compound's biological effects have been substantiated in rat models, indicating its promise for further exploration in pharmacological studies. -
Endogenous Metabolite
Chondrosamine, 6-phosphate is an endogenous metabolite that plays a critical role in amino sugar metabolism. This amino sugar phosphate compound is involved in multiple biochemical pathways related to sugar metabolism. Its relevance in studying cellular metabolism and synthetic pathways makes it a valuable reagent for research applications in biochemistry and molecular biology. -
Endogenous Metabolite
TRIA-662 iodide, also known as 1-Methylnicotinamide chloride, is an endogenous metabolite that primarily targets pathways associated with inflammation and thrombosis. This compound exhibits notable antithrombotic and anti-inflammatory activities, making it valuable for research applications focused on cardiovascular health and inflammatory diseases. Its role in cellular metabolism further highlights its potential in studying metabolic dysregulation and related disorders. -
Endogenous Metabolite
β-Nicotinamide adenine dinucleotide reduced dipotassium (NADH) functions primarily as a key coenzyme in redox reactions. It serves as a donor of ADP-ribose units in ADP-ribosylation processes and is a precursor to cyclic ADP-ribose. Additionally, NADH plays a vital role in cellular energy metabolism, contributing to pathways such as glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle, making it essential for various research applications in metabolic studies and cellular function analysis. -
Endogenous Metabolite
IST-622 is an endogenous metabolite exhibiting significant anti-tumor activity through the inhibition of cancer cell growth. It demonstrates potent growth inhibitory effects against various mouse tumor models, including P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, and Colon 26 and 38 adenocarcinomas. Additionally, IST-622 is effective in human tumor xenograft models, notably large cell lung carcinoma and gastric adenocarcinoma. In vitro studies reveal an IC50 for P388 leukemia that is over 20 times lower than conventional treatments, underscoring its potential as a therapeutic agent in oncology research. -
Endogenous Metabolite
GCN2iB acetate is a selective inhibitor of the GCN2 kinase, primarily targeting the Gcn2 signaling pathway. It enhances the phosphorylation of eIF2, leading to increased expression of Atf4, particularly in Gcn2 mutants with specific alterations in regulatory regions or kinase domain substitutions. This compound is valuable for studying cellular responses to nutritional stress and has potential applications in cancer research, specifically in sensitizing cancer cells with low levels of aspartate synthetase to the anti-leukemic agent L-aspartase. -
Endogenous Metabolite
1-Myristoyl-2-(4-nitrophenylsuccinyl)-sn-glycero-3-phosphocholine is a synthetic phospholipid that primarily targets cell membranes to inhibit cell proliferation. This compound serves as an effective carrier to enhance the bioavailability of various therapeutic agents. Additionally, it is an important tool in cell membrane research, facilitating the study of cell signal transduction pathways. -
Endogenous Metabolite
GNE-783 is a selective checkpoint kinase 1 (CHK1) inhibitor that plays a pivotal role in modulating the cell cycle response to DNA damage. By inactivating S-phase and G2-phase checkpoints, it enhances the efficacy of anti-metabolite chemotherapeutics, such as gemcitabine and temozolomide, particularly in melanoma cell lines. GNE-783 is instrumental in research applications focused on overcoming drug resistance and improving treatment outcomes across various tumor types. -
Endogenous Metabolite
Prostaglandin D1 is an endogenous metabolite known for its role as a prostanoid. It exhibits both contractile and relaxant effects on isolated human pial arteries and acts as an inhibitor of ADP-induced platelet aggregation, with an IC50 value of 320 ng/ml. This compound is useful for studies in metabolic research and vascular biology. -
Endogenous Metabolite
Letimide hydrochloride is an endogenous metabolite with potent analgesic activity. In vitro studies have demonstrated its cytogenetic effects on human lymphocytes, while in vivo assessments in mouse bone marrow cells have shown no significant chromosomal aberrations or sister chromatid exchanges. Additionally, teratogenic studies in mice indicate that Letimide hydrochloride does not induce congenital malformations, supporting its safety profile for research applications in pain management and genetic stability. -
Endogenous Metabolite
(8Z,14Z)-Eicosadienoic acid is an endogenous metabolite classified as an ω-8 C20:2 fatty acid. It has been detected in human milk, corresponding to 0.19% of total fatty acids. This compound can be converted in vivo by desaturases into eicosatrienoic acids, which are known for their potent vasodilatory effects. The specific physiological effects of (8Z,14Z)-eicosadienoic acid remain to be fully explored, making it a valuable candidate for further research into its biological roles and potential therapeutic applications. -
Endogenous Metabolite
D-Fructose 6-phosphate dipotassium is an endogenous metabolite that primarily targets metabolic pathways related to cell growth and autophagy. It plays a crucial role as an intermediate in glycolysis and the pentose phosphate pathway, and it is hydrolyzed by fructose-1,6-bisphosphatase. This compound can also be converted into D-glucose 6-phosphate by phosphoglucose isomerase, making it relevant in studies of metabolic disorders, including Lewy body dementia. Researchers can utilize D-Fructose 6-phosphate dipotassium to explore cellular metabolism and related pathological conditions. -
Endogenous Metabolite
Fexaramate is a selective agonist of the farnesoid X receptor (FXR), an endogenous metabolite involved in bile acid homeostasis and lipid metabolism. This compound plays a crucial role in regulating glucose and lipid levels, making it valuable for research into metabolic disorders, liver diseases, and therapeutic interventions targeting FXR signaling pathways. Its specific action on FXR enhances understanding of its physiological functions and potential therapeutic applications. -
Endogenous Metabolite
Promothiocin A is a thiopeptide that acts as an inducer of the tipA promoter. This compound is derived from the bacterium Streptomyces sp. SF2741 and functions as an endogenous metabolite, playing a pivotal role in gene regulation. Its ability to modulate bacterial gene expression makes Promothiocin A a valuable reagent for research applications in microbiology and molecular biology, particularly in studies focused on transcriptional control mechanisms. -
Endogenous Metabolite
A-57696 is a cholecystokinin (CCK) antagonist that selectively targets cortical CCK-B receptors with an IC50 of 25 nM. It functions as a competitive antagonist, effectively reversing CCK8-induced pancreatic alpha-amylase secretion and phosphatidylinositol degradation, while also inhibiting CCK8-induced gallbladder contraction. Notably, A-57696 exhibits partial agonist activity at CCK-B/gastrin receptors on NCI-H345 cells, eliciting up to 80% of the maximal CCK8 response. This compound serves as a valuable tool in research focused on gastrointestinal physiology and the modulation of CCK-related pathways. -
Fungal Metabolite
Fellutanine A is a diketopiperazine alkaloid that serves as a fungal metabolite derived from Penicillium fellutanum. This compound exhibits significant biological activity, demonstrating potential antifungal properties. It can be utilized in research focused on studying fungal physiology and the development of antifungal agents. -
Endogenous Metabolite
Sorbitol-6-phosphate 2-dehydrogenase from Escherichia coli is a key enzyme that facilitates the conversion of D-sorbitol 6-phosphate to D-fructose 6-phosphate. This dehydrogenase exhibits a significantly faster rate of oxidation of D-sorbitol 6-phosphate, being ten times more efficient than the reduction of D-fructose 6-phosphate. It is vital for various metabolic pathways and cellular processes, making it a valuable reagent for research in metabolic engineering and enzymology studies. -
Endogenous Metabolite
1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) is an endogenous metabolite that serves as a key structural component in cellular membranes. This lipid, identified in rat brain tissue through mass spectrometry imaging, exhibits unique structural and distribution properties. It has implications in research focused on lipid metabolism and neurobiology, facilitating the exploration of fatty acid chain isomers and their roles in physiological processes. -
Endogenous Metabolite
3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid is an endogenous metabolite identified in urine that plays a significant role in biological processes. It is utilized in research related to autism, aiding in the investigation of metabolic pathways and potential biomarkers. This compound may provide insights into the biochemical alterations associated with neurodevelopmental disorders. -
Endogenous Metabolite
PG 9 maleate is an endogenous metabolite that primarily enhances central cholinergic transmission, resulting in analgesic effects. This compound demonstrates protective activity against memory loss induced by agents such as scopolamine and dicyclomine within a defined dosage range. Notably, PG 9 maleate exhibits significant selectivity for the M4/M1 receptor subtypes, suggesting a potential mechanism underlying its analgesic and neuroprotective properties. Additionally, it promotes acetylcholine release, thereby enhancing its overall biological efficacy. -
Endogenous Metabolite
Prosulfocarb is an effective herbicide that targets selective weed species in winter cereals. Its primary mechanism involves the inhibition of the biosynthesis of essential fatty acids in plants. This compound is instrumental in managing biotic resistance among weed populations, contributing to more effective agricultural practices. Research applications include studies on environmental impact, residue transfer, and the volatility effects that influence contamination patterns in target and non-target areas. -
Endogenous Metabolite
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a modified phospholipid that serves as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). With an IC50 value of 2 μM at a substrate concentration of 0.5 mM, Thioetheramide-PC interacts with both the catalytic and activation sites of the enzyme, exhibiting tighter binding to the activation site. This unique dual interaction may facilitate phospholipase activation at low concentrations, making Thioetheramide-PC a valuable tool for studying sPLA2-related biological processes and mechanisms. -
Endogenous Metabolite
AZD-3199 is an ultra-long-acting beta2 adrenergic agonist primarily targeting the beta2 adrenergic receptor. It exhibits significant bronchodilator activity, making it a candidate for therapeutic use in asthma and chronic obstructive pulmonary disease (COPD) research. Its prolonged action facilitates investigations into novel treatment strategies for managing these respiratory conditions. -
Endogenous Metabolite
Dabrafenib carboxylic acid is the carboxylate metabolite of dabrafenib, primarily functioning as an endogenous metabolite. This compound retains the capacity to modulate signaling pathways associated with MAPK/ERK pathway alterations. It serves as a valuable tool for studying the pharmacokinetics and biological effects of dabrafenib in cancer research, particularly in the context of melanoma and other tumors with BRAF mutations. -
Endogenous Metabolite
Ranelic acid is an endogenous metabolite with metal cation chelating activity. It plays a vital role in the inhibition of osteoporosis and the enhancement of bone mineral density. Additionally, derivatives of ranelic acid display complex and highly substituted thiophene ring structures, providing potential avenues for further research in bone health and related metabolic pathways. -
Endogenous Metabolite
KBP-5493 is an endogenous metabolite that can be detected in biological fluids such as urine and plasma. This compound plays a significant role in metabolic pathways and may provide insights into various physiological processes. Its detection is essential for research applications in metabolomics and biomarker discovery. -
Fungal Metabolite
Stephacidin B is a fungal metabolite that exhibits significant cytotoxic activity against various human tumor cell lines. Notably, it demonstrates the strongest cytotoxic effects against testosterone-dependent LNCaP prostate cancer cells. This compound can be utilized in cancer research applications to explore therapeutic strategies and mechanisms of action related to prostate cancer. -
Endogenous Metabolite
SU9518 is a selective tyrosine kinase inhibitor targeting PDGFRα, demonstrating significant anti-fibrotic properties. This compound effectively inhibits the progression of proliferative vitreoretinopathy (PVR) in rabbit models involving fibroblasts and Müller cells, showing promising results without discernible toxicity. SU9518 holds potential for therapeutic applications in PVR and other proliferative ocular disorders characterized by fibrosis and gliosis. -
Endogenous Metabolite
PF-05387252 is a potent and selective inhibitor of IRAK4, effectively targeting endogenous Toll-like receptor (TLR) signaling pathways. This compound exhibits significant anti-inflammatory activity in experimental models, suggesting potential therapeutic applications in conditions such as psoriasis. While PF-05387252 has demonstrated efficacy in reducing inflammation in animal studies, its effectiveness in clinical settings for psoriasis has yet to be established. -
Endogenous Metabolite
Darexaban maleate is a direct factor Xa inhibitor, primarily utilized in the research of venous thromboembolism prevention. Its major metabolite, Darexaban glucitol, exhibits pharmacological activity and is formed in the human liver and intestine via UGT1A9 and UGT1A10-mediated glucitolation. The glucitolation exhibits a K(m) value greater than 250 μM in the liver, while in the intestine, it displays substrate inhibition kinetics with a K(m) of 27.3 μM. The presence of fatty acid-free bovine serum albumin significantly lowers the unbound K(m) values in human liver microsomes and UGT1A9. -
Endogenous Metabolite
13-cis-Vitamin A palmitate is an endogenous metabolite and a geometrical isomer of vitamin A palmitate. Exhibiting approximately 75% of the biological activity of all-trans-vitamins A palmitate, this compound is crucial in various physiological processes, including vision and cellular differentiation. It serves as an important research tool in studies focused on retinoid metabolism and its implications in health and disease. -
Endogenous Metabolite
α-Triglycidyl isocyanurate is an antitumor agent that primarily targets DNA by alkylating and cross-linking its structure, thereby inhibiting DNA replication. This compound demonstrates significant cytotoxic effects and maintains stability in fresh human plasma and whole blood, indicating favorable biocompatibility. Metabolism predominantly occurs in rat liver via an NADPH-independent pathway, and the complexity of its metabolic processes allows for a partial restoration of cytotoxicity under specific conditions. Its properties make α-Triglycidyl isocyanurate a valuable reagent for cancer research and therapeutic studies. -
Endogenous Metabolite
1,3-Dipalmitoyl-2-linoleoylglycerol is a triacylglycerol characterized by the presence of palmitic acid at the sn-1 and sn-3 positions and linoleic acid at the sn-2 position. This compound serves as an endogenous metabolite involved in various biological processes, including cellular signaling and lipid metabolism. It is relevant for research applications focused on lipid biochemistry, metabolism studies, and the exploration of membrane dynamics. -
Endogenous Metabolite
Palmitoleic acid sodium is an endogenous metabolite that plays a crucial role in lipid metabolism and cell signaling. This fatty acid has been shown to possess potential neuroprotective effects, particularly in the context of cerebrovascular disorders. It is utilized in research for its ability to modulate inflammatory pathways and support cardiovascular health, making it a valuable tool for studies related to metabolic disease and stroke prevention. -
Endogenous Metabolite
Atrazine mercapturate is an endogenous metabolite of the herbicide Atrazine, detectable in urinary samples. This compound serves as a reliable biomarker for confirming human exposure to Atrazine, facilitating research into its environmental and health impacts. Its detection is critical for studies on herbicide metabolism and toxicity in various populations. -
Endogenous Metabolite
Circumdatin A is an endogenous metabolite isolated from a fungal culture, characterized through detailed NMR spectral analysis. It exhibits potential biological activities that are currently being investigated in various research applications, particularly in the fields of biochemistry and natural product chemistry. Its unique structural attributes may contribute to understanding metabolic pathways and fungal biosynthesis. -
Endogenous Metabolite
(S)-3,4-Dihydroxybutyric acid sodium is an endogenous metabolite primarily associated with the metabolism of gamma-aminobutyric acid (GABA). It is notably excreted at elevated levels in individuals with succinic semialdehyde dehydrogenase (SSADH) deficiency. This compound serves as a valuable biomarker for diagnostic research and metabolic studies related to GABAergic dysfunction and neurological disorders. -
Endogenous Metabolite
PMPMEase-IN-2 is an inhibitor of polyprenylated protein methylesterase, targeting the regulation of polyprenylated protein metabolism. This regulation is crucial for maintaining normal cellular function and survival, with dysregulation linked to degenerative diseases and cancer. PMPMEase-IN-2 holds potential applications in cancer research, providing a specific approach for investigating the modulation of polyprenylated protein pathways. -
Endogenous Metabolite
Uridine 5'-triphosphate tris salt acts primarily as an endogenous metabolite involved in cellular energy transfer and nucleotide synthesis. It plays critical roles in RNA synthesis and is essential for various biochemical pathways, including signal transduction and cellular metabolism. This reagent is widely utilized in research applications such as studying nucleoside triphosphate dynamics and investigating metabolic processes in cell biology. -
Endogenous Metabolite
Triflusulfuron-methyl is a selective herbicide that acts by inhibiting the enzyme acetolactate synthase (ALS), which is crucial for the biosynthesis of branched-chain amino acids. It demonstrates significant biological activity in controlling specific weed species by disrupting their growth and development. This compound is commonly used in agricultural research to study herbicide resistance mechanisms and assess crop safety against ALS inhibitors. -
Endogenous Metabolite
Moperone hydrochloride is a selective antagonist of the dopamine D2 receptor. It demonstrates significant biological activity in modulating dopaminergic neurotransmission, making it valuable in the research of psychiatric disorders such as schizophrenia and other dopamine-related conditions. This compound is essential for studies aimed at understanding the role of dopamine in mental health and the development of antipsychotic therapies. -
Endogenous Metabolite
sEH-IN-12 is a potent inhibitor of soluble epoxide hydrolase (sEH) that effectively blocks its activity. This compound demonstrates strong biological activity and has been utilized in the construction and selection of small molecule libraries. The development of sEH-IN-12 offers a valuable tool for drug discovery efforts aimed at targeting sEH for therapeutic interventions. -
Fungal Metabolite
Aculene A is a norsesquiterpene derived from the fungus Aspergillus aculeatus, primarily targeting fungal metabolic pathways. It exhibits significant biological activity, making it valuable for research applications in mycology and natural product studies. Aculene A may serve as a lead compound for investigating fungal interactions and the development of antifungal agents. -
Endogenous Metabolite
Neogen, also known as Jadinol PU, is an endogenous metabolite that plays a crucial role in immune system restoration and hematopoiesis. It demonstrates significant activity in supporting the recovery of immune functions following cytotoxic treatments. This compound is particularly useful in research focused on improving outcomes for patients undergoing chemotherapy. -
Endogenous Metabolite
Antiarrhythmic agent-3 is an endogenous metabolite that enhances the efficacy of antiarrhythmic treatments while improving the inhibition index. Its antiarrhythmic properties are associated with its hydrophobicity, reflected in its log P value. Additionally, its potential central nervous system toxicity is linked to the interplay between its hydrophobic characteristics and acid constant (pKa). This compound is primarily utilized in research related to cardiac rhythm management and toxicity studies.
