Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
12-Oxo-leukotriene B4 is an endogenous metabolite and an important intermediate in the lipoxygenase-catalyzed metabolism of arachidonic acid. This compound plays a crucial role in the biosynthesis of leukotriene B4 and is involved in inflammatory responses. It stimulates intracellular calcium levels in human neutrophils with an EC50 of 33 nM and promotes neutrophil migration with an EC50 of 170 nM. Its biological activity makes it a valuable tool for research in inflammation and immune response studies. -
Endogenous Metabolite
(2R)-Pasireotide (diaspartate) is a potent somatostatin analog with a primary mechanism of action targeting somatostatin receptor 5 (SST5). It demonstrates a 40-fold higher affinity for SST5 compared to other somatostatin analogs, making it a valuable tool for studying somatostatin signaling pathways. This compound is primarily used in research applications focused on neuroendocrine tumors and other conditions influenced by somatostatin receptor activity. -
Endogenous Metabolite
C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is an endogenous metabolite characterized by a long-chain fatty acid (24:1) linked to a 1-deoxysphingoid backbone. This lipid molecule accumulates in conditions such as obesity and type 2 diabetes, contributing to cellular toxicity due to its inability to be further metabolized into complex sphingolipids. Research applications include studies of lipid metabolism, obesity, and the pathophysiology of metabolic disorders, particularly in differentiated adipocytes. -
Endogenous Metabolite
5-trans Prostaglandin F2α is an endogenous metabolite with a significant role in cardiovascular physiology. It is primarily involved in the modulation of vascular tone and plays a critical role in inflammatory responses. This compound is essential for researching myocardial infarction and other cardiovascular disorders as it provides insights into the underlying metabolic and physiological mechanisms. -
Endogenous Metabolite
Propane-1,2,3-triyl tritricosanoate is a triacylglycerol that serves as an internal standard for the quantification of fatty acids. It contains tricosanoic acid at all three acyl positions and has applications in studying the triglyceride component of human aortic endothelial cells (HAECs) cultured in media supplemented with stearic and/or oleic acid. This reagent is essential for accurately assessing lipid metabolism and fatty acid composition in complex biological systems. -
Endogenous Metabolite
4,7,10,13,16-Docosapentaenoic acid is an endogenous metabolite that plays a crucial role in cellular signaling and lipid metabolism. Its biological activity includes anti-inflammatory properties and modulation of oxidative stress. This compound is valuable in research focusing on metabolic disorders, cardiovascular diseases, and inflammation-related studies. -
Endogenous Metabolite
SKF 106760 is a potent antagonist of the platelet fibrin receptor glycoprotein IIb/IIIa, demonstrating significant antiplatelet and antithrombotic activities. This compound effectively inhibits platelet aggregation in vitro and prevents thrombus formation within stenotic carotid arteries. Additionally, SKF 106760 exhibits efficacy against aspirin-resistant thrombi that occur in high-grade stenosis conditions, making it a valuable tool for investigating antithrombotic therapies in cardiovascular research. -
Endogenous Metabolite
5,7-Dihydroxy-11-ketotetranorprostanoic acid is an endogenous metabolite of prostaglandin F2α, serving as a precursor to tetranor-PGF metabolites. This compound plays a significant role in various biological pathways related to prostaglandin metabolism. While it exhibits minimal activity in blood pressure and smooth muscle stimulation assays, it is valuable for research in prostaglandin-related studies and urinary metabolite profiling. -
Fungal Metabolite
7-Hydroxypestalotin is a fungal metabolite known for its ability to modulate biological pathways. This compound exhibits significant antifungal activity, making it a valuable tool in the study of fungal biology and pathogen resistance. Its unique properties can be utilized in various research applications, including the development of antifungal agents and the exploration of fungal metabolism. -
Endogenous Metabolite
Inosine oxime is an endogenous metabolite that plays a role in cellular metabolism, primarily generated through the activity of cytochrome P450, oxidative stress, or altered nucleotide biosynthesis. This compound exhibits toxic and mutagenic effects in both prokaryotic and eukaryotic cells, making it a valuable tool for research into cellular responses to stress and mutagenesis. Its utility extends to studies investigating metabolic pathways and the impact of metabolites on cellular function. -
Endogenous Metabolite
Roxatidine hydrochloride is an anti-ulcer agent that primarily targets the inhibition of gastric acid secretion. This compound effectively prevents the formation of duodenal and gastric ulcers while alleviating ulcer-related pain. With a favorable safety profile, Roxatidine hydrochloride demonstrates effective therapeutic potential even at lower doses compared to similar agents, making it a valuable tool for gastroenterological research. -
Endogenous Metabolite
BCM-599 is an endogenous metabolite that functions as a hepatitis B virus (HBV) capsid assembly inhibitor. It demonstrates potent antiviral activity with an IC50 value of 0.88 μM and a CC50 value of 144 μM in HepG2.2.15 cells. When administered in conjunction with lamivudine, BCM-599 exhibits a synergistic effect, enhancing the reduction of viral concentration. This compound is a valuable tool for investigating combined strategies for the treatment of HBV infection. -
Endogenous Metabolite
Mannose 1-phosphate is an endogenous metabolite that serves as a critical precursor in glycosylation pathways. It participates in the synthesis of GDP-mannose via the action of the enzyme GDP-mannose pyrophosphorylase. This compound is integral for research applications focusing on glycoprotein biosynthesis and metabolic pathways involving mannose derivatives. -
Endogenous Metabolite
Trimoxamine hydrochloride is an antihypertensive agent that functions primarily by inhibiting vasoconstriction, leading to a reduction in blood pressure. This compound is valuable for the management of hypertension-related diseases and cardiovascular disorders. Its primary mechanism as an endogenous metabolite underlines its potential role in clinical and research applications targeting cardiovascular health. -
Endogenous Metabolite
Sabiporide mesylate is a selective inhibitor of sodium-hydrogen exchange, primarily targeting NHE1. This compound exhibits cardioprotective properties, rendering it an important reagent for studies on myocardial ischemia and myocardial infarction. Its ability to modulate sodium and hydrogen ion transport makes it useful in exploring cellular mechanisms linked to cardiac stress responses. -
Endogenous Metabolite
4-Amino-L-phenylalanine hydrochloride is an endogenous metabolite that serves as a precursor in various biochemical pathways. Its biological activity includes modulation of neurotransmitter synthesis and regulation of metabolic processes. This compound is primarily utilized in research involving amino acid metabolism, neurobiology, and the broader study of physiological functions related to phenylalanine derivatives. -
Endogenous Metabolite
Ethylenediaminediacetic acid (EDDA) serves as a key ligand, effectively enhancing the antiproliferative activities of metal complexes. These complexes demonstrate significant antiproliferative effects in the MCF-7 cancer cell line and exhibit the capacity to interact with DNA, as analyzed through circular dichroism (CD) and electron paramagnetic resonance (EPR) spectroscopy. Additionally, EDDA and its metal complexes can induce cell cycle arrest at the G(0)/G(1) phase, highlighting their potential application in cancer research. Structural analysis of EDDA contributes valuable insights into its biological mechanisms and interactions. -
Endogenous Metabolite
MIPS1455 is a light-activated ligand that targets the M1 muscarinic acetylcholine receptor, exhibiting irreversible binding at the allosteric site. This compound demonstrates significant potential in modulating receptor activity, with applications in researching cognitive deficits and allosteric interactions. MIPS1455 may serve as a valuable molecular tool for further exploration of receptor pharmacology and related therapeutic implications. -
Endogenous Metabolite
AZD-6605 is a potent, reversible inhibitor targeting matrix metalloproteinases MMP2, MMP9, MMP12, and MMP13, exhibiting high selectivity. This compound was optimized for enhanced activity, solubility, and drug metabolism and pharmacokinetics (DMPK) properties by modifying the zinc hydroxide binding group found in traditional inhibitors. AZD-6605 is valuable for investigating the roles of these metalloproteinases in various biological processes and disease states, making it suitable for research applications in inflammation, cancer, and tissue remodeling studies. -
Endogenous Metabolite
1,2-Distearoyl-3-arachidoyl-rac-glycerol is an endogenous metabolite involved in the study of triglyceride composition, particularly in bovine milk fat. This compound has been identified and quantified through various analytical methods, contributing to a better understanding of lipid profiles in dairy research. Its applications extend to investigations into lipid metabolism and the nutritional properties of milk-derived products. -
Endogenous Metabolite
Cinosulfuron is a selective herbicide that targets specific enzyme activity to effectively inhibit a range of broadleaf weeds. Its use in agricultural practices enhances crop yield and quality by managing weed infestations, thereby promoting optimal growth conditions for desirable plants. This compound serves as a crucial tool in effective farmland management and sustainable agriculture. -
Endogenous Metabolite
A-62198 is a selective renin inhibitor that exhibits significant antihypertensive properties. It effectively reduces mean arterial pressure (MAP) in anesthetized, salt-deprived primate models in a dose-dependent manner. Notably, A-62198 also demonstrates a statistically significant decrease in plasma renin activity (PRA) across all administered doses, making it a valuable tool for research in cardiovascular pharmacology and hypertension studies. -
Endogenous Metabolite
NSC-84096 is an endopeptidase activity inhibitor that effectively inhibits the enzymatic activity of botulinum neurotoxin type A light chain (rBoNT/A-LC). Its ability to block this neurotoxin in vitro suggests a significant potential for use in research focused on botulism and related neurotoxic disorders. The mechanism of action for NSC-84096 may facilitate the development of small molecule therapeutics targeting these hazardous toxins. -
Endogenous Metabolite
Deoxygerfelin, an endogenous metabolite derived from A. versicolor, exhibits significant phenolic antioxidant properties. It effectively scavenges free radicals, demonstrated through its activity in Trolox equivalent antioxidant capacity (TEAC) assays. This compound can be utilized in research applications aimed at studying oxidative stress and its effects on cellular processes. -
Endogenous Metabolite
p18SMI-21 is an innovative inhibitor targeting the INK4C protein, effectively blocking the biological activity of p18. This compound exhibits a significant reduction in the proteolytic activity of pepsin, demonstrating its potential as an anti-gastric acid agent. Its inhibitory efficacy is notably influenced by dosing and requires direct contact with the substrate to maintain its effect. p18SMI-21 is valuable for researchers investigating gastric acid dynamics and the regulatory mechanisms of p18 in cellular metabolism. -
Endogenous Metabolite
Gletimbetasin is a thymosin β4 analog that functions primarily as an endogenous metabolite. This compound exhibits notable anti-inflammatory activity, making it a valuable tool for investigating the molecular mechanisms underlying inflammation. Its applications extend to studies focused on wound healing, tissue regeneration, and cellular responses to stress, providing insights into potential therapeutic strategies for inflammatory diseases. -
Endogenous Metabolite
(5aS,6R,6aR)-MK-8666 functions as a selective agonist of the GPR40 receptor, primarily targeting pancreatic β cells and intestinal enteroendocrine cells to enhance fatty acid-induced insulin secretion. This compound has been investigated for its potential in the treatment of type 2 diabetes, demonstrating significant reductions in blood glucose levels. Despite its therapeutic promise, development ceased during Phase I clinical trials due to concerns regarding liver safety. -
Endogenous Metabolite
PSI 352707 is an endogenous metabolite of sofosbuvir, functioning as an antiviral compound. It demonstrates significant activity against chronic hepatitis C virus infections, exhibiting favorable safety and tolerability profiles. PSI 352707 is utilized in research related to antiviral drug mechanisms and hepatitis C treatment strategies. -
Endogenous Metabolite
Pemetrexed tromethamine (dihydrochloric) dihydrate is an endogenous metabolite targeting folate metabolism, primarily utilized as a chemotherapeutic agent. It exhibits potent anti-cancer activity, making it effective in the treatment of pleural mesothelioma and non-small cell lung cancer. This compound is instrumental in cancer research, particularly in studies focused on folate pathway inhibitors and their therapeutic implications. -
Endogenous Metabolite
7α,24(S)-Dihydroxycholesterol is an endogenous metabolite that functions as a selective ligand for liver X receptors (LXR), specifically binding to the ligand binding domains of both LXRα and LXRβ. This compound plays a significant role in cholesterol metabolism and homeostasis, making it valuable for research applications in lipid biology and metabolic disorders. Its synthesis involves a series of transformations starting from E-α,β-enone and using Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde. -
Endogenous Metabolites
8-Iso-15-keto prostaglandin F2β is an endogenous metabolite derived from 8-Iso PGF2β through the 15-hydroxy-PG dehydrogenase pathway. This compound is known to exhibit vasoconstrictive properties in pulmonary veins, particularly in canine and porcine models. It serves as a valuable tool for investigating the physiological roles of prostaglandins and their metabolites in cardiovascular research. -
Endogenous Metabolite
1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite primarily found in cerebrospinal fluid. This compound serves as a valuable tool in the investigation of Parkinson's Disease, aiding in the understanding of its biochemical pathways and potential therapeutic targets. Its presence and activity in neurobiological contexts make it significant for research aimed at elucidating the mechanisms underlying neurodegenerative disorders. -
Endogenous Metabolite
AVE-8063 hydrochloride is an endogenous metabolite that modulates inflammatory responses, making it relevant for research in inflammatory bowel disease (IBD). This compound exhibits potential therapeutic mechanisms that can enhance precision targeting in contemporary treatment strategies for IBD. Its application in scientific studies may contribute to a better understanding of the inflammatory processes involved in gastrointestinal disorders. -
Endogenous Metabolite
(-)-Carveol is a natural unsaturated monocyclic monoterpene alcohol known for its ability to regulate neural excitability. This compound can modulate neural activity through structural changes, making it significant for the development of targeted therapeutic agents. Additionally, (-)-Carveol serves roles as a fragrance in cosmetic applications and as a flavor additive in the food industry, highlighting its versatility in various research contexts. -
Endogenous Metabolite
11-Deoxyprostaglandin F2β is an endogenous metabolite that serves as an analog of PGF2β, generated through the cyclooxygenase metabolism of arachidonic acid. This compound is known to induce a dose-dependent release of hexose-containing mucin, making it useful in research related to mucin secretion and related physiological processes. It is applicable in studies investigating inflammatory responses and the modulation of lipid signaling pathways. -
Endogenous Metabolite
C16 1-Deoxyceramide (m18:1/16:0) is an endogenous metabolite that serves as a lipid molecule characterized by a long-chain fatty acid (16:0) linked to a 1-deoxysphingoid backbone. This compound has been shown to accumulate in conditions such as obesity and type 2 diabetes, where it is toxic due to its inability to be further metabolized into more complex sphingolipids. Research indicates that C16 1-Deoxyceramide levels increase in differentiated adipocytes, suggesting its potential role in metabolic disorders and lipid signaling pathways. -
Endogenous Metabolite
Tiracizine hydrochloride is an endogenous metabolite identified as a Class I antiarrhythmic agent, primarily targeting myocardial function. It exhibits a significant reduction in myocardial contractility, making it relevant for research into ischemic heart disease and related cardiac conditions. This compound may prove beneficial for understanding mechanisms underlying heart disease management and the assessment of cardiac function. -
Endogenous Metabolite
Paranyline is an endogenous metabolite known for its anti-inflammatory properties. It is primarily utilized in research focused on the mechanisms underlying arthritis and other inflammatory conditions. Paranyline functions by modulating inflammatory pathways, making it a valuable tool for studying therapeutic interventions in chronic inflammation. Its unique biochemical activity supports investigations into potential treatment avenues for various inflammatory diseases. -
Endogenous Metabolite
R1663 is a selective inhibitor of factor Xa, demonstrating significant anticoagulant activity without affecting bleeding time. Its pharmacodynamic effects, such as the inhibition of thrombin generation, are dose-dependent, contributing to the prolongation of clotting time in a concentration-dependent manner. R1663 effectively reduces the peak height of thrombin generation and the endogenous thrombin potential, making it a valuable tool for research in coagulation and thrombus formation. -
Endogenous Metabolite
18-HETE is a monooxygenase metabolite of cytochrome P450 (CYP450), specifically derived from arachidonic acid, which features a hydroxy substituent at position 18. This compound plays a significant role in various biological processes, including the regulation of blood flow and inflammation. It is commonly utilized in research applications investigating the roles of lipid mediators in cellular signaling and disease mechanisms. -
Endogenous Metabolite
8(R)-HETE is an endogenous metabolite produced through the lipoxygenation of arachidonic acid, predominantly found in marine invertebrates such as gorgonian corals and starfish. This compound serves as a key mediatory in various biological processes, including inflammatory responses. 8(R)-HETE's stereochemical configuration as the (R) enantiomer has been confirmed through comparisons with established chiral HPLC retention times. Its study is relevant in understanding the role of bioactive lipids in marine biology and potential implications in human health. -
Endogenous Metabolite
Estriol 3-glucuronide is an endogenous metabolite that plays a crucial role in the metabolism of estrogen. It is primarily found in amniotic fluid during normal pregnancy and is also excreted in urine. This compound is useful for research applications related to reproductive biology, hormone regulation, and fetal development studies. -
Endogenous metabolites
(5R)-Dinoprost tromethamine is a natural metabolite derived from arachidonic acid via cyclooxygenase activity. It is known to stimulate the dose-dependent release of hexosaccharide-rich mucin, highlighting its role in mucosal physiology. This compound is utilized in research applications focused on understanding prostaglandin signaling and its effects on various biological processes. -
Endogenous Metabolite
Abieslactone is an endogenous metabolite known for its anti-tumor promoting activity. It demonstrates potential for therapeutic applications in oncology, making it a valuable tool for research focused on cancer treatment and prevention. Its unique properties may contribute to the development of novel anti-cancer strategies. -
Endogenous Metabolite
1,2-Dioleoyl-3-myristoyl-rac-glycerol is an endogenous metabolite investigated as a triglyceride within the fat body of bumblebees. Analyses using chromatography have identified variations in fatty acid composition and triglyceride isomer distribution across different bumblebee species. This compound serves as a valuable tool for studying lipid metabolism and fatty acid biosynthesis within diverse biological systems. -
Endogenous Metabolite
ODE-Bn-PMEG is an antiviral compound that targets human papillomavirus (HPV) by inhibiting the amplification of viral DNA. Demonstrating robust activity against HPV-11, -16, and -18, ODE-Bn-PMEG effectively reduces transient viral replication in transfected cells without reaching cytotoxic levels. The compound exhibits enhanced uptake in human foreskin fibroblasts and is converted to the active antiviral metabolite PMEG diphosphate in vitro. Additionally, the P-chiral enantiomer of ODE-Bn-PMEG maintains comparable antiviral efficacy, highlighting its potential for use against multiple HPV strains and in local therapeutic applications. -
Endogenous Metabolite
Bis(1-chloro-2-propyl) phosphate (BCIPP) is an endogenous metabolite derived from organophosphate flame retardants (OPFR). It has been shown to impact energy metabolism through modifications to steroid hormone levels, including cortisol and cortisone. BCIPP is particularly relevant for investigating metabolism-related diseases linked to environmental exposures and may serve as a valuable tool in toxicological and endocrinological research. -
Endogenous Metabolite
Propazine is a triazine herbicide primarily targeting the inhibition of photosynthesis in weed species. It demonstrates notable efficacy in controlling broad-leaved weeds and annual grasses, making it particularly valuable in sweet sorghum cultivation. This compound serves as an essential tool for researchers studying herbicide resistance and plant growth regulation in agricultural systems. -
Endogenous Metabolite
Indeloxazine, a brain-active compound, primarily targets neurotransmitter systems to enhance cognitive function. Demonstrating significant anti-amnesic activity, Indeloxazine has been shown to prolong step latency in senescence-accelerated mice (SAM-P/8/Ta), indicating its efficacy in improving brain function. Additionally, Indeloxazine is recognized for its anticonvulsant properties, providing further evidence of its potential applications in neuroprotection and behavioral enhancements in various research settings. -
Endogenous Metabolite
UCCF-029 free base is a potent activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This compound showcases enhanced activity due to the benzannulation of the flavone A-ring at the 7,8-position, serving as a critical structural reference for the development of more effective flavonoid analogues. UCCF-029 demonstrates superior potency compared to apigenin in activating wild-type CFTR and possesses potential for activating the mutant G551D-CFTR, though its efficacy in this regard is not as pronounced as that of apigenin. This reagent is valuable for research into cystic fibrosis and related therapeutic strategies.
