Fig. 1 · Structure
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GCN2iB acetate
Cat. No.
A73468
CAS
2183470-13-3
Endogenous Metabolite
GCN2iB acetate is a selective inhibitor of the GCN2 kinase, primarily targeting the Gcn2 signaling pathway. It enhances the phosphorylation of eIF2, leading to increased expression of Atf4, particularly in Gcn2 mutants with specific alterations in regulatory regions or kinase domain substitutions. This compound is valuable for studying cellular responses to nutritional stress and has potential applications in cancer research, specifically in sensitizing cancer cells with low levels of aspartate synthetase to the anti-leukemic agent L-aspartase.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2183470-13-3 |
| Applications | Endogenous Metabolite |
| Formula | C20H16ClF2N5O5S |
| Molecular Weight | 511.89 |
| SMILES | O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(C(C#CC3=CN=C(N=C3)N)=C2F)F)=O.CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.