Fig. 1 · Structure
Documents & Downloads
GNE-783
Cat. No.
A73472
CAS
1200127-66-7
Endogenous Metabolite
GNE-783 is a selective checkpoint kinase 1 (CHK1) inhibitor that plays a pivotal role in modulating the cell cycle response to DNA damage. By inactivating S-phase and G2-phase checkpoints, it enhances the efficacy of anti-metabolite chemotherapeutics, such as gemcitabine and temozolomide, particularly in melanoma cell lines. GNE-783 is instrumental in research applications focused on overcoming drug resistance and improving treatment outcomes across various tumor types.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1200127-66-7 |
| Applications | Endogenous Metabolite |
| Formula | C22H20N6 |
| Molecular Weight | 368.43 |
| SMILES | N#CC1=NC=C2C(C3=CC(C4=CC=C(N5CCN(C)CC5)C=C4)=CN=C3N2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.