Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Nafenopin is an endogenous metabolite that acts as a peroxidase proliferator, demonstrating liver tumor-promoting activity. This compound is recognized for its role in managing hyperlipoproteinemia and inducing oxidative stress in vivo, particularly in hepatic tissue. Nafenopin's unique mechanisms of action differentiate it from other non-genotoxic carcinogens, making it a valuable tool for research related to liver pathology and metabolic disorders. -
Endogenous Metabolite
Cellobiosan is an anhydrosugar derived from the combustion of biomass. As an endogenous metabolite, it plays a significant role in various biological processes, including energy metabolism and carbohydrate digestion. Cellobiosan is utilized in research applications focusing on metabolic pathways, the environmental impact of biomass burning, and the study of carbohydrate-derived compounds. -
Endogenous Metabolite
2,4-D methyl ester is an endogenous metabolite that serves as a biostimulant, promoting the accumulation of key nutritional and medicinal components. This compound has been shown to enhance the production of bioactive constituents in Cordyceps militaris, exhibiting an inductive effect that is concentration-dependent. Research applications include improving the fruit quality of Cordyceps militaris, making 2,4-D methyl ester a valuable tool for enhancing natural product yields in various biological studies. -
Endogenous Metabolite
04:1 Coenzyme A trisodium is a specific form of coenzyme A (CoA) characterized by a four-carbon acyl chain with one double bond. This reagent plays a critical role in various biochemical pathways, facilitating the transfer of acyl groups and participating in lipid metabolism. It is essential for studying metabolic processes, enzymatic reactions, and cellular signaling mechanisms involving acyl-CoA derivatives. -
Endogenous Metabolite
Xanthosine dihydrate is a nucleoside that serves as an endogenous metabolite, derived from xanthine and ribose. It has been shown to enhance the population of mammary stem cells and promote milk production in livestock such as cattle and goats. This compound is valuable for research in metabolic regulation and agricultural biotechnology. -
Endogenous Metabolite
Monononadecanoin is an endogenous metabolite known for its anti-inflammatory and antioxidant properties. This lipid compound is utilized in various research applications related to skin moisturization and repair, as well as flavor enhancement and preservation in food products. Its biological activities make it a valuable tool in studying skin health and food science. -
Endogenous Metabolite
Amino acid arylamidase, derived from hog kidney, is a metalloprotease that specifically hydrolyzes proteins or peptides with free α-amino or α-imino groups. This enzyme plays a significant role in amino acid metabolism and protein digestion. Its activity can be inhibited through N-terminal acetylation, making it a valuable tool in studies related to hepatic diseases, biliary disorders, and heart failure research. -
Endogenous Metabolite
2-(1-Hydroxypentyl)benzoic acid is an endogenous metabolite with potential therapeutic implications in the treatment of acute ischemic stroke (AIS). This compound may exert neuroprotective effects, making it a valuable candidate for research aimed at understanding stroke pathophysiology and developing novel therapeutic strategies. Its role in metabolic pathways and cellular signaling may provide insights into neuroprotection and recovery processes after ischemic events. -
Endogenous Metabolite
D-Glyceric acid calcium hydrate is an endogenous metabolite primarily involved in metabolic processes. It serves as a valuable research tool for studying primary hyperoxaluria type I and glutaric acidemia type 2. Its biological significance makes it useful in exploring metabolic disorders and related conditions. -
Endogenous Metabolite
1,2-Dioleoyl-3-α-linolenoyl-rac-glycerol is a triglyceride that serves as an endogenous metabolite, primarily studied for its role in lipid metabolism within the bumblebee fat body. Analytical techniques, including chromatography, have identified variations in fatty acid composition and triglyceride isomer distribution among different bumblebee species. This compound is valuable for research focused on insect physiology, lipid biochemistry, and comparative metabolomics. -
Endogenous Metabolite
2,4-Dihydroxybutanoic acid is an endogenous metabolite associated with metabolic pathways related to succinic semialdehyde dehydrogenase deficiency. This compound is typically undetectable in normal human urine but is found in elevated levels in affected individuals. It serves as a valuable biomarker for metabolic disorders and can aid in the study of neurological conditions linked to enzyme deficiencies. -
Endogenous Metabolite
hLTA4H/hLTA4S-IN-1 is a dual inhibitor targeting human leukotriene hydrolase (hLTA4H) and human leukotriene C4 synthase (hLTC4S). This compound effectively disrupts the leukotriene biosynthesis pathway, making it valuable for studying inflammatory responses at the cellular level. hLTA4H/hLTA4S-IN-1 serves as a useful tool for research focused on leukotriene-related diseases and inflammatory conditions. -
Endogenous Metabolite
1-Stearo-3-linolein is a diacylglycerol featuring stearic acid at the sn-1 position and linoleic acid at the sn-3 position. This compound serves as an endogenous metabolite with implications in lipid metabolism and signaling pathways. It is utilized in research to study the roles of diacylglycerols in cellular processes and their effects on various biochemical pathways. -
Endogenous Metabolite
14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide is an endogenous metabolite characterized by its butadiene lactone structure. This compound exhibits significant biological activity in various metabolic pathways, making it a valuable tool for research in life sciences. Its potential applications include studying metabolic processes and exploring molecular interactions in biological systems. -
Endogenous Metabolite
AP219 is a control compound featuring a mitochondria-targeting triphenylphosphonium scaffold, specifically designed for research applications involving endogenous metabolites. While AP219 does not release hydrogen sulfide (H2S), it serves as a valuable tool for studying the effects of H2S in mitochondrial processes when used alongside H2S-releasing compounds like AP39. This compound can aid in elucidating the role of mitochondrial H2S in cellular biology and its potential implications in various disease models. -
Endogenous Metabolite
KRP-109 is a potent inhibitor of neutrophil elastase (NE), demonstrating significant activity in mitigating lung inflammation. In mouse models, KRP-109 has been shown to enhance survival rates and decrease neutrophil accumulation within the alveolar walls. This compound effectively reduces cell and neutrophil counts in bronchoalveolar lavage fluid, as well as lowers levels of pro-inflammatory cytokines, including interleukin 1β and macrophage inflammatory protein 2. KRP-109 is valuable for research focused on severe pneumonia and associated inflammatory conditions. -
Endogenous Metabolite
1,2-Dinonanoyl-sn-glycero-3-phosphocholine is an endogenous metabolite that serves as a specific phosphatidylcholine, influencing membrane dynamics through its unique fatty acyl configurations. This phospholipid plays a crucial role in membrane composition and is essential for the generation of eicosanoids. Its structure, with fatty acids linked to glycerol at the sn-1 and sn-2 positions via ester bonds, positions it as an important reagent for studying lipid signaling and membrane biology. -
Endogenous Metabolite
3-(Stearoyloxy)propane-1,2-diyl dioleate is a triacylglycerol derivative characterized by oleic acid at the sn-1 and sn-2 positions, while stearic acid occupies the sn-3 position. This endogenous metabolite is found in various plant oils, including sunflower, corn, and soybean oils, as well as ostrich oil. Its unique structure and fatty acid composition make it valuable for studies in lipid metabolism, cellular signaling, and the exploration of dietary fats in nutritional research. -
Endogenous Metabolite
Rofleponide epimer is an endogenous metabolite that targets glucocorticoid receptors, exhibiting significant anti-inflammatory activity. It demonstrates high selectivity for lung tissues and effectively binds to the rat thymic glucocorticoid receptor, reinforcing its pharmacological efficacy. Additionally, Rofleponide epimer has a biotransformation rate that is ten times greater than that of similar compounds, highlighting its potential for therapeutic applications in managing inflammatory diseases affecting mucosal surfaces. -
Endogenous Metabolite
Pitstop 1 is a small molecule inhibitor that targets the endocytic pathway. It effectively disrupts the interaction between chaperones and the Krasin terminal domain, leading to altered Krasin functionality. This compound demonstrates potent biological activity by inhibiting Krasin-mediated signaling and is valuable in research applications focused on viral entry and pathogen interactions with host cells. -
Endogenous Metabolite
MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor that demonstrates sub-nanomolar activity against wild-type viruses and common NNRTI-resistant RT mutants, including K103N and Y181C. This compound exhibits significant antiviral efficacy, particularly against K103N and Y181C mutant strains. When evaluated against 12 common NNRTI-associated mutant viruses, MK-6186 shows minimal resistance, with most viral strains demonstrating fold change values below 10. In clinical virus isolates harboring NNRTI-resistant mutations, a majority exhibit significantly reduced resistance to MK-6186 compared to other treatments. This positions MK-6186 as a promising candidate for research focused on combating NNRTI-resistant HIV strains. -
Endogenous Metabolite
D-myo-Inositol-1,4,5,6-tetraphosphate (D-Ins(1,4,5,6)P4) functions primarily as an endogenous metabolite involved in cellular signaling pathways. This compound exhibits a strong inhibitory effect on calcium-activated chloride channels, effectively operating at concentrations of 8-10 μM. It is commonly utilized in research applications focused on signal transduction and ion channel regulation. -
Endogenous Metabolite
1-Myristoyl-2-Linoleoyl-3-Oleoyl-rac-glycerol is a triacylglycerol composed of myristic acid, linoleic acid, and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. This compound is recognized as an endogenous metabolite and is naturally occurring in mature human milk, infant formula fats, and butterfat. It plays a significant role in lipid metabolism and can be utilized in research focused on nutrition, fat digestion, and developmental studies. -
Endogenous Metabolite
2,6,6-Trimethylbicyclo[3.1.1]heptan-3-ol is an endogenous metabolite primarily isolated from Chrysanthemum indicum L. This compound exhibits potential biological activity relevant to various biochemical pathways. It serves as a valuable tool in research focused on the metabolic profiles of plant-derived substances and their implications in pharmacological studies. -
Endogenous Metabolite
(S)-Pomalidomide is an angiogenesis-inhibiting compound that targets endogenous metabolites to exhibit significant growth-inhibitory effects on B-cell tumors. It has demonstrated the capacity to induce complete tumor regression in Burkitt lymphoma cells, making it a valuable tool in cancer research. Additionally, (S)-Pomalidomide functions as an immunomodulator, with potential applications in the treatment of hematological malignancies. -
Leukotrienes
14,15-Leukotriene C4 is a leukotriene compound generated from the enzymatic metabolism of arachidonic acid. This molecule plays a pivotal role in promoting inflammatory responses by enhancing vascular permeability, resulting in the extravasation of fluid and white blood cells into surrounding tissues. Due to its biological activity, 14,15-Leukotriene C4 is valuable for research applications related to asthma and various inflammatory disorders. -
Endogenous Metabolite
12-OxoETE is an endogenous metabolite that functions primarily through leukotriene B4 receptors, eliciting a rapid, dose-dependent increase in cytoplasmic free calcium levels. This compound is valuable in research focusing on calcium signaling pathways and the roles of eicosanoids in cellular responses. Its effects on calcium mobilization make it a useful tool for studying inflammatory processes and leukocyte activation. -
Endogenous Metabolite
8-iso-13,14-dihydro-15-keto Prostaglandin F2α is an oxidative metabolite of 8-iso-prostaglandin F2α, functioning as an endogenous metabolite. This compound plays a significant role in the study of oxidative stress-related diseases by providing insights into the biological effects of oxidative damage on cellular pathways. Its applications extend to research on various pathological conditions influenced by oxidative stress, helping to deepen the understanding of disease mechanisms and potential therapeutic interventions. -
Fungal Metabolite
tert-Pentylbenzene is a volatile aromatic hydrocarbon identified as a fungal metabolite. It can be isolated from the saprophytic fungus Memnoniella sp. This compound is of interest in research applications focused on fungal biochemistry and metabolic profiling, contributing insights into fungal metabolite diversity and ecological roles. -
Endogenous Metabolite
Hepaxanthin, also known as 5,6-Monoepoxy vitamin A or 5,6-Epoxyretinol, is an endogenous metabolite derived from 5,6-monoepoxyvitamin A aldehyde. While it is considered an inactive carotenoid, its accumulation in the liver suggests potential roles in metabolic pathways related to vitamin A metabolism. This compound can be utilized in research studying vitamin A derivatives and their impact on liver function. -
Endogenous Metabolite Inhibitor
NADH-IN-2 is a potent inhibitor of Type II NADH dehydrogenase, an enzyme involved in the electron transport chain and cellular respiration. By selectively targeting this enzyme, NADH-IN-2 can modulate metabolic processes and influence energy production in cells. This compound is useful in research applications investigating bioenergetics, mitochondrial function, and metabolic disorders. -
Endogenous Metabolite
1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid characterized by the presence of stearic acid and adrenic acid at the sn-1 and sn-2 positions, respectively. This endogenous metabolite has been shown to demonstrate an inverse correlation with age in mitochondria extracted from human post-mortem hippocampus, suggesting its potential role in age-related mitochondrial function. It serves as a valuable tool for research into lipid metabolism and neuronal health. -
Endogenous Metabolite
Lantanose A is an oligosaccharide derived from the root of Lantana camara, serving as an endogenous metabolite. It exhibits significant biological activity and is of interest in various research applications, particularly in the study of plant metabolism and interactions with biological systems. Researchers may explore its potential benefits in understanding metabolic pathways and physiological responses in different organisms. -
Fungal Metabolite
Avellanin B is a fungal metabolite known for its pressor effects. It exhibits significant bioactivity that may modulate vascular resistance and blood pressure. This compound can be utilized in research focused on cardiovascular dysfunction and the physiological impacts of fungal metabolites. -
Endogenous Metabolite
Laidlomycin propionate is an endogenous metabolite that enhances weight gain and feed conversion efficiency in livestock. It is primarily used as a feed additive in cattle farming, demonstrating significant improvements in daily weight gain, feed intake, and carcass weight. Extensive research has highlighted its potential to reduce production costs and increase profitability within the cattle industry, although findings may vary across different studies in North America. -
Endogenous Metabolite
Diethylumbelliferyl phosphate (DEUP) acts as a selective and potent inhibitor of cholesterol esterase. This compound effectively disrupts steroidogenesis by inhibiting the transport of cholesterol into the mitochondria of steroidogenic cells, with an IC50 of 11.6 μM. DEUP is valuable in research applications focused on cholesterol metabolism and steroid hormone synthesis. -
Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid that functions as an inhibitor of class B metallo-β-lactamases (MBLs). It specifically inactivates these enzymes by chelating the essential Zn2+ cofactor, effectively promoting the degradation of zinc-deficient NDM-1 and enhancing the efficacy of β-lactam antibiotics. This compound serves as a selective Zn2+ scavenger, demonstrating broad potential for research applications aimed at understanding and overcoming β-lactam resistance in bacterial pathogens. -
Endogenous Metabolite
22:0 PC (1,2-Didocosanoyl-sn-glycero-3-phosphocholine) is an endogenous metabolite primarily acting as a lung surfactant. As an amphipathic phosphatidylcholine, it is mainly localized in the outer leaflets of biological membrane bilayers. This compound is crucial for maintaining alveolar stability and surface tension, making it valuable for research applications in pulmonary biology, membrane dynamics, and lipid metabolism studies. -
Endogenous Metabolite
LAPAO (Laurylamidopropyldimethylamine oxide) is an amphoteric surfactant known for its excellent biocompatibility and surface-active properties. It exhibits significant detergent and foam-enhancing capabilities, making it suitable for applications in personal care and household cleaning products. LAPAO maintains stability across a range of pH values and effectively removes dirt and grease, while also providing conditioning benefits that enhance the performance of skin and hair care formulations. -
Endogenous Metabolite
Hemi-Oxanthromicin A is a polyketide derived from the bacterium Streptomyces. This compound acts as an endogenous metabolite, exhibiting notable antibacterial activity. It is primarily utilized in research focused on microbial secondary metabolites and their potential therapeutic applications. -
Endogenous Metabolite
(Z)-9-Heptadecenoic Acid is an endogenous metabolite classified as a monounsaturated fatty acid. This compound serves as a significant component of ruminant fat and milk, where its concentrations have been observed to negatively correlate with methane production in cattle on high-lipid diets. Research applications include studies on lipid metabolism, ruminant nutrition, and the mitigation of greenhouse gas emissions in livestock. -
Endogenous Metabolite
Propyl nicotinate, also known as nicotinic acid propyl ester, is an endogenous metabolite that serves as the propyl ester of niacin. It plays a crucial role in the biosynthesis of coenzymes NAD and NADP, which are essential for various metabolic processes. Propyl nicotinate is utilized in research focusing on metabolic regulation and coenzyme activity, contributing to the understanding of cellular respiration and energy metabolism. -
Endogenous Metabolite
Ozolinone is an endogenous metabolite derived from the biotransformation of the diuretic elkapin in mammals, primarily functioning as a potent diuretic agent. It exhibits significant diuretic properties across various species, making it valuable for research in renal physiology and fluid regulation studies. Its role in understanding metabolic pathways and the efficacy of diuretic compounds further supports its application in biochemical research. -
Endogenous Metabolite
(25R)-26-Hydroxycholest-4-en-3-one is an oxysterol and an important endogenous metabolite. It plays a significant role in the regulation of cholesterol metabolism and cellular signaling pathways. This compound is relevant for research applications related to lipid biology, cardiovascular diseases, and metabolic disorders. -
Endogenous Metabolite
9(R)-HODE cholesteryl ester is an endogenous metabolite associated with atherosclerotic lesions. This compound serves as a valuable standard for the analysis of chiral HODE cholesteryl esters, allowing for the investigation of lipid oxidation processes and their biochemical implications. Its utility in research extends to studies exploring the role of oxidized fatty acids in cardiovascular disease and metabolic disorders. -
Endogenous Metabolite
Phomosine D is an endogenous metabolite derived from the fungus Phomopsis. This compound demonstrates various biological activities, making it valuable for research into fungal metabolism and the ecological roles of secondary metabolites. Its unique profile aids in exploring potential applications in biomedical research and natural product chemistry. -
Endogenous Metabolite
8(R),9(S)-EET is an isomer of epoxyeicosatrienoic acid with a primary mechanism involving metabolism by cytosolic epoxide hydrolase (cEH). This compound demonstrates significant biological activity related to lipid signaling pathways and modulates vascular tone and inflammation. It serves as a valuable tool in research applications exploring cardiovascular biology and related metabolic processes. -
Endogenous Metabolite
POPi (phloridzin oxidation product i) is an endogenous metabolite produced by the oxidation of phloridzin, catalyzed by apple polyphenol oxidase. This compound exhibits DPPH radical-scavenging activity, making it a valuable tool in antioxidant research. Its role in studying oxidative stress and potential therapeutic applications enhances its utility in the exploration of metabolic pathways and antioxidant mechanisms. -
Endogenous Metabolite
4(Z),7(Z)-Decadienoic acid is an endogenous metabolite that functions as a fatty acid and is identified as a component of the cloacal gland secretion in the tuatara (Sphenodon punctatus). This compound may be utilized in studies investigating lipid metabolism, animal physiology, and chemical ecology. Its unique structure and biological role make it relevant for research into the chemical signaling pathways and evolutionary adaptations of reptiles. -
Endogenous Metabolite
ML262 is a potent inhibitor of hepatic lipid droplet formation, with an IC50 of 6.4 nM in murine AML-12 cells. This compound is significant in research related to non-alcoholic fatty liver disease, as it selectively targets lipid metabolism without inducing cytotoxicity at concentrations up to 33 μM. Additionally, ML262 does not interfere with fatty acid uptake at concentrations up to 50 μM, making it a valuable tool for studying lipid homeostasis and related metabolic disorders.
