Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Lactosyl-C18-sphingosine is a bioactive sphingolipid that functions as a lysoganglioside, specifically a form of lactosylceramide without the fatty acyl group. It exhibits the ability to reduce the viability of human neutrophils in a concentration-dependent manner at low micromolar concentrations (1-50 μM). Unlike its counterpart, lactosylceramide, Lactosyl-C18-sphingosine does not affect protein synthesis or cell proliferation in cardiomyocytes, making it a unique tool for studying sphingolipid signaling and metabolism in various biological contexts. -
Endogenous Metabolite
N-Lauroyl-L-glutamic acid is an amino acid derivative targeting endogenous metabolic pathways. This compound exhibits anti-asthmatic properties and has demonstrated efficacy in reducing asthma symptoms in various studies. Its primary applications involve the potential management and suppression of respiratory diseases, offering prospects for enhanced patient quality of life in clinical settings. -
Endogenous Metabolite
Disperse Red 1 acrylate is an endogenous metabolite that acts as a crucial component in non-linear optical (NLO) materials. This compound is primarily utilized in research applications related to photonics and materials science, contributing to the development of advanced optical devices. Its unique properties make it suitable for exploring new methodologies in NLO applications. -
Endogenous Metabolite
8-Hydroxy loxapine is an oxidative metabolite of Loxapine, primarily known for its relatively low biological activity compared to its counterpart 7-OH-loxapine. This compound serves as a valuable tool in neurological research, particularly in studies related to the pharmacokinetics and metabolic pathways of antipsychotic medications. Its role as an endogenous metabolite allows for investigations into the physiological implications of Loxapine metabolism in various biological systems. -
Endogenous Metabolite
(±)-Geosmin is a natural organic compound known for its distinctive earthy aroma. It functions as an endogenous metabolite with significant roles in microbial metabolism. This compound is widely utilized in studies related to environmental monitoring, particularly for detecting soil and water pollution, as well as in the flavor and fragrance industries. -
Endogenous Metabolite
Glucoalyssin is an endogenous metabolite primarily known for its role as a major glucosinolate in Degenia velebitica. It exhibits significant antioxidant activity, contributing to the protective mechanisms in various biological systems. This compound is utilized in plant taxonomy research, aiding in the classification and study of plant species based on their glucosinolate profiles. Its unique properties make it valuable for studies focused on plant defense mechanisms and metabolic profiling. -
Endogenous Metabolite
Stearoyl serotonin is a hybrid compound designed to target the endogenous metabolite systems and is structurally derived from arachidonoyl serotonin. This compound is investigated for its ability to function as a dual antagonist of fatty acid amide hydrolase (FAAH) and the TRPV1 channel, which are critical pathways in the modulation of pain. Preliminary studies suggest that modifications to the arachidonoyl structure, such as the introduction of an 18-carbon stearoyl moiety, may influence TRPV1 channel activity; replacement with saturated fatty acids has demonstrated significant inhibition of capsaicin-induced activation. This positions stearoyl serotonin as a potential candidate for research into pain mechanisms and therapeutic applications. -
Endogenous Metabolite
11(Z),14(Z),17(Z)-Eicosatrienoic acid methyl ester is a naturally occurring metabolite found in the microalga Nannochloropsis. This compound exhibits notable biological activity and serves as a valuable research tool for studying metabolic pathways and the effects of environmental pollutants. Additionally, it can be isolated from diesel-contaminated soil, highlighting its relevance in environmental toxicology and bioremediation studies. -
Endogenous Metabolite
Carprazidil is a potent vasodilator primarily targeting the modulation of vascular smooth muscle tone. It demonstrates significant efficacy in suppressing severe hypertension and managing mild heart failure. Research applications include investigating the drug's cardiovascular effects and exploring its potential side effects, such as sodium retention and increased heart rate, as well as its impact on hirsutism in women. Notably, carprazidil does not adversely affect hematological parameters or liver and kidney function, making it a valuable compound for cardiovascular research. -
Endogenous Metabolite
Fluazuron is an insect growth regulator that targets the molting process in larvae of Amblyomma sculptum. Demonstrating 100% efficacy, Fluazuron rapidly absorbs and exhibits slow metabolism, making it a promising candidate for controlling the Brazilian spotted fever. Its effectiveness suggests potential applications in developing feed products designed to manage tick populations in free-living capybaras, contributing to effective pest management strategies. -
Endogenous Metabolite
Sarcinapterin is an L-glutamyl derivative of the coenzyme methanopterin, acting as a key endogenous metabolite. This compound plays a crucial role in methanogenic pathways and is primarily studied in the context of microbial metabolism, particularly in organisms like Methanosarcina barkeri. Its research applications extend to biochemical studies of methanogenesis and metabolic profiling in anaerobic environments. -
Endogenous Metabolite
(±)9-HODE cholesteryl ester is an endogenous metabolite derived from atherogenic processes, particularly identified within atherosclerotic lesions. This compound is formed through the Cu2+-catalyzed oxidation of low-density lipoprotein (LDL) and is further metabolized by 15-lipoxygenase (15-LO) in rabbit reticulocytes and human monocytes from cholesteryl linoleate, a predominant LDL component. Its relevance in lipid metabolism and atherosclerosis research makes it a valuable reagent for studies investigating cardiovascular diseases and oxidative stress mechanisms. -
Endogenous Metabolite
Lunine is an endogenous metabolite derived from the alkaloid Lunasia quercifolia. This compound demonstrates stability against various conditions, including acids, bases, oxidants, and reducing agents. Lunine can be utilized to study metabolic pathways and the biochemical roles of alkaloids in cellular processes. Its unique properties make it valuable for research in pharmacology and natural product chemistry. -
Endogenous Metabolite
Ala-Ala-Phe-AMC is a fluorogenic substrate primarily used for the detection of proteolytic activity. Its positively charged characteristics enhance its suitability for various biochemical assays, enabling researchers to investigate protease function in biological samples. This compound is valuable in studies related to protein turnover, cellular signaling, and disease mechanisms involving proteolysis. -
Endogenous Metabolite
D-2-Phosphoglyceric acid is a crucial endogenous metabolite involved in cellular energy metabolism and biosynthesis regulation. It plays an essential role in glycolysis and photosynthesis, contributing to the overall energy supply for cells. Additionally, D-2-Phosphoglyceric acid serves as a valuable biomarker for assessing metabolic status across various organisms in research applications. -
Endogenous Metabolite
BTPTT-4F is a non-fullerene acceptor-donor-acceptor (A-D-A) small molecular acceptor (SMA) with a unique ladder-type electron-deficient core, flexible alkyl chains, and a centrally fused ring structure. This compound exhibits significant potential in organic photovoltaic applications, particularly when blended with PM6, leading to enhanced solar cell performance. Its optimized optical properties and adjustable electronic energy levels contribute to improved thermal and photochemical stability, making BTPTT-4F a promising candidate for research in next-generation high-efficiency organic solar cells. -
Endogenous Metabolite
(S)-KT109 is a selective inhibitor of diacylglycerol lipase β (DAGLβ), exhibiting an IC50 of 39.81 nM. This compound demonstrates lower inhibitory effects on DAGLα, with an IC50 of 794.3 nM, and shows reduced activity against α/β-amidase domain-containing 6 (ABHD6) at an IC50 of 630.9 nM. (S)-KT109 is valuable for research investigating the roles of endocannabinoids in various biological pathways, particularly those involving lipids and neurobiology. -
Endogenous Metabolite
(+/-)-Adomeglivant is a selective glucagon receptor antagonist that exerts hypoglycemic effects by inhibiting glucagon signaling. This compound is effective in lowering blood glucose levels in both healthy individuals and patients with type 2 diabetes. Its use has been associated with a reduction in fasting and postprandial glucose, alongside a reversible increase in aminotransferases. The potential of (+/-)-Adomeglivant as an inhibitory approach in the management of type 2 diabetes merits further investigation in clinical studies to fully assess its benefits and risks. -
Endogenous Metabolite
5(S)-HETrE is a metabolite derived from the ω-6 fatty acid γ-linolenic acid, playing a significant role in lipid metabolism. Elevated levels of 5(S)-HETrE have been observed in serum from obesity mouse models, suggesting its potential involvement in metabolic disorders. This compound serves as a valuable tool for research into obesity, inflammation, and related metabolic pathways. -
Endogenous Metabolite
(Z)-Octadec-13-enoic acid, also known as cis-13-Octadecenoic acid, is a monounsaturated fatty acid that serves as an endogenous metabolite. This compound is primarily derived from bovine milk fat and plays a significant role in various biological processes, including lipid metabolism and cell signaling. It is valuable for research applications that investigate fatty acid profiles and their physiological effects in different biological systems. -
Endogenous Metabolite
(R)-Coriolic acid is an endogenous metabolite derived from the metabolism of linoleic acid through the action of lipoxygenase. It has been identified in the supernatants and membranes of cultured bovine endothelial cells, reflecting its role in COX-mediated pathways. Additionally, (R)-Coriolic acid is recognized as a weak inhibitor of U-46619-induced platelet aggregation, with an IC50 of 2.7 µM. This compound is valuable for research on lipid metabolism, cardiovascular function, and platelet biology. -
Endogenous Metabolite
2-Hydroxy-3-(palmitoyloxy)propyl stearate is a diacylglycerol featuring palmitic acid at the sn-1 position and stearic acid at the sn-3 position. This endogenous metabolite is identified in palm-derived diacylglycerols, including those from palm oil and palm stearin, as well as in extracts from wheat bran and brewer’s spent grain. It holds potential for research in lipid metabolism and may provide insights into nutritional and health-related studies involving dietary fats. -
Endogenous Metabolite
Yokonoside is an endogenous metabolite with potential cardioprotective properties derived from Aconitum japonicum. This cardiac glycoside demonstrates antioxidant activity, making it relevant for research into oxidative stress and cardiac health. It is valuable for studies investigating the biological effects of natural compounds in cardiovascular and metabolic research. -
Endogenous Metabolite
9Z,11E,13Z-Octadecatrienoic acid methyl ester, also known as methyl punicate, is an endogenous metabolite derived from Punica granatum L. This fatty acid methyl ester demonstrates significant antitumor activity by disrupting the tumor cell cycle, modulating drug resistance, and inhibiting angiogenesis. Its unique properties make it a valuable tool for research in cancer therapeutics and metabolic studies. -
Endogenous Metabolite
Isariin C is a flavonoid glycoside that functions as an endogenous metabolite with notable antioxidant activity. Primarily, it has been shown to activate angiogenesis, making it a valuable tool in research related to vascular development and regulation. Additionally, Isariin C exhibits insecticidal properties in various insect species, positioning it as a potential candidate for studies in pest management and toxicology. -
Endogenous Metabolite
(R,R,S)-GAT107 is a potent positive allosteric modulator of the α7 nicotinic receptors, exhibiting robust agonistic activity. This compound primarily functions through its (+)-isomer, demonstrating significant biological effects, while the (-)-isomer shows no such activity. Research indicates that (R,R,S)-GAT107 is currently recognized as the most effective ago-PAM for α7 nicotinic receptors, suggesting promising avenues for further investigation in vivo. Potential applications include studies related to cognitive enhancement and neuroinflammation. -
Endogenous Metabolite
9(R)-HODE is a monohydroxy fatty acid and an endogenous metabolite of linoleic acid, generated through the enzymatic actions of cyclooxygenase (COX) and lipoxygenase (LO). This compound is known to promote chemotaxis and elevate the expression of chemokine receptors CCR9 and CXCR4 in immune cells. Additionally, 9(R)-HODE effectively inhibits interleukin-6 (IL-6) release in primary human monocytes and suppresses CD3α- and CD28-induced proliferation in isolated human peripheral blood lymphocytes at a concentration of 25 μg/mL, making it a valuable tool for studying immune responses and inflammatory processes. -
Endogenous Metabolite
(+)-Adomeglivant is a selective antagonist of the glycogenotropin receptor, exhibiting significant glucose-lowering activity. Its ability to effectively reduce fasting blood glucose levels makes it a valuable tool for studying hyperglycemia mechanisms in type 2 diabetes. Additionally, the antagonistic properties of (+)-Adomeglivant may complicate assessments of the metabolic effects associated with postprandial hyperglycemia, providing insights into the intricacies of metabolic regulation in diabetic conditions. -
Endogenous Metabolite
Cephapirin lactone is an endogenous metabolite derived from the antibiotic cephapirin. This compound serves as a significant marker in pharmacokinetic studies and can be utilized to explore metabolic pathways associated with beta-lactam antibiotics. Research applications include investigating the metabolic fate of cephapirin and assessing potential impacts on therapeutic efficacy. -
Endogenous Metabolite
(±)-Mellein is an endogenous metabolite with a chemical structure of 8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one, primarily derived from the marine organism Helicascus kanaloanus. This compound has garnered interest in biochemical research due to its potential biological activity, including roles in cellular signaling and metabolic pathways. Research applications may encompass studies of metabolic processes and effects on various biological systems. -
Fungal Secondary Metabolite
Endocrocin is an anthraquinone and a notable fungal secondary metabolite. It functions primarily as a chemotaxis inhibitor, exhibiting significant immunosuppressive properties. This compound is valuable in research focused on immune response modulation and the study of fungal-derived metabolites in therapeutic applications. -
Endogenous Metabolite
Lignoceroyl ethanolamide is an endogenous metabolite belonging to the fatty N-acyl ethanolamine class, which are recognized as endocannabinoids. This compound may play a role in various biological processes, although the specific functions and significance of its ethanolamine derivative remain to be fully elucidated. Research involving lignoceroyl ethanolamide could provide insights into endocannabinoid signaling pathways and their implications in neurological functions. -
Endogenous Metabolite
Glutamic acid diethyl ester acts as a glutamate antagonist and functions as an endogenous metabolite. This compound is utilized in biochemical research to investigate the mechanisms of glutamate signaling. Additionally, it serves as a precursor for the synthesis of various derivatives and exhibits potential industrial applications. Its unique properties position it as a valuable reagent in compound development efforts. -
Endogenous Metabolite
Methylbenzethonium chloride hydrate is a quaternary ammonium compound that acts as an endogenous metabolite. It exhibits antimicrobial activity and can be utilized in various biochemical research applications, particularly in the study of surface-active agents and their interactions with biological membranes. This reagent is commonly used in experiments involving cell membrane permeability and antimicrobial efficacy assessments. -
Endogenous Metabolite
DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a unique endogenous metabolite that features an inverted charge orientation compared to conventional phosphocholine lipids. This compound contains a quaternary amine located near the bilayer interface, along with a phosphate group extending into the aqueous environment. This distinctive configuration allows for the investigation of biophysical properties and the biological implications of charge inversion at the bilayer surface, making it valuable for studies in membrane biology and lipid interactions. -
Endogenous Metabolite
BFE-37 is an endogenous metabolite that exhibits significant heat resistance, making it ideal for studying microbial stability in food products. It demonstrates a survival rate change of 6.53 log CFU/mL after exposure to 55 °C for 5 minutes in acidic orange juice. The compound's dynamic behavior at varying temperatures reveals a first-order logarithmic linear inactivation characteristic, underscoring its robustness under heat treatment. Research involving BFE-37 contributes to understanding the effects of mild heat treatments on juice products and aids in the development of microbial control strategies within the food industry. -
Endogenous Metabolite
Trans-Phenothrin is a synthetic pyrethroid that primarily targets adult arthropods, exhibiting insecticidal properties against fleas and ticks. Significant differences in biological activity have been observed among its enantiomers when compared to fenvalerate and d-trans-phenothrin. This compound is utilized in agricultural research for its effectiveness as an insecticide against pests like Plutella xylostella, making it a valuable reagent in entomological studies and pest management strategies. -
Endogenous Metabolite
Lentztrehalose A is a trehalose analog that functions as an endogenous metabolite. It exhibits notable antitumor activity and is isolated from actinomycetes. This compound is useful in cancer research and cellular metabolism studies, providing insights into its potential therapeutic applications. -
Endogenous Metabolite
(Z)-Octadec-8-enoic acid, also known as cis-8-octadecenoic acid, is a monounsaturated fatty acid and an essential endogenous metabolite. This compound demonstrates significant biological activity, serving as a key component in lipid metabolism and cellular signaling pathways. Research applications include studies related to metabolism, dietary impacts on health, and the role of fatty acids in various physiological processes. Found naturally in partially hydrogenated vegetable oils and milk fat, it is relevant for investigations into dietary fats and their biological implications. -
Endogenous Metabolite
Isomer-CM 352 is an antifibrinolytic agent targeting matrix metalloproteinases. This compound demonstrates significant ability to reduce hematoma expansion while promoting functional and neurological recovery in models of intracerebral hemorrhage. Isomer-CM 352 enhances neurological outcomes by inhibiting hematoma growth, indicating its potential application in the management of acute neurological conditions. -
Fungal Metabolite
2-(2-Hydroxypropionylamino)-benzamide is a fungal metabolite that functions as a proangiogenic agent. This compound has been shown to stimulate blood vessel formation, making it valuable for research focused on angiogenesis and related biological processes. Its unique properties may provide insights into therapeutic applications in areas such as wound healing and tissue regeneration. -
Endogenous Metabolite
NE58018 is a potent inhibitor of bone resorption, primarily targeting Farnesyl pyrophosphate synthase (FPPS). This compound demonstrates enhanced inhibitory activity due to its structural features and the presence of aminophosphonates. NE58018 modulates the interactions of Thr201 and Tyr204 residues, which are critical for substrate binding and catalysis, thereby increasing the overall inhibition of FPPS. It is useful in research related to bone metabolism and related disorders. -
Endogenous Metabolite
Butenachlor is a selective herbicide targeting endogenous metabolites in plants. It is utilized for the effective control of grass and certain broad-leaved weeds, demonstrating significant herbicidal activity. This compound is primarily applied in agricultural research to study plant physiology and weed management strategies. -
Endogenous Metabolite
DL-4-Hydroxy-2-ketoglutarate acts as a substrate for the enzymes glutamic oxalacetic aminotransferase (GOT) and 2-keto-4-hydroxyglutarate aldolase, mediating the reversible conversion of 2-keto-4-hydroxyglutarate to pyruvate and glyoxylate. This endogenous metabolite is valuable in mass spectrometry applications for the rapid analysis of negatively charged, water-soluble cellular metabolites, aiding in metabolic pathway studies and biomarker discovery. -
Endogenous Metabolite
ADR-925 is an active chelated iron metabolite known for its protective effects against doxorubicin-induced damage in neonatal rat cardiomyocytes. This compound plays a crucial role in cellular iron homeostasis and may enhance cell viability under stress conditions. ADR-925 is primarily utilized in research applications focused on cardiotoxicity, metabolic regulation, and iron-related cellular pathways. -
Endogenous Metabolite
Hexaenoic acid is a very long chain polyunsaturated fatty acid (VLCPUFA) that serves as an endogenous metabolite in cellular membranes, particularly in ceramides and sphingomyelin. This C34:6 compound is predominantly found in the retina, sperm, and brain tissues. Its specific biological activities remain largely uncharacterized, but research suggests that it may play a role in the activation of protein kinase C, making it a candidate for studies on lipid signaling and cellular function. -
Endogenous Metabolite
Cyperin is an endogenous metabolite derived from the fungus A. cypericola, primarily targeting enoyl-acyl carrier protein reductase (ENR) in plants, with an IC50 of 89 μM. It exhibits phytotoxic effects by inducing necrosis in various plant species and significantly inhibiting root growth in A. thaliana seedlings, with an IC50 of 38.4 μM. Cyperin serves as a valuable tool for studying plant stress responses and investigating the mechanisms of phytotoxicity in plant biology. -
Endogenous Metabolite
(2R,3R)-2,3,4-Trihydroxybutanoic acid, commonly referred to as erythronic acid, functions as an endogenous metabolite involved in various biological processes. This naturally occurring organic acid is present in multiple biological fluids, including aqueous humor, urine, plasma, cerebrospinal fluid, and synovial fluid, in both healthy adults and children. Its production occurs through the oxidation of GlcNAc, making it a valuable compound for research into metabolic pathways and related health studies. -
Endogenous Metabolite
Methyl dotriacontanoate is a naturally occurring fatty acid methyl ester. It serves as an endogenous metabolite found in the cuticular wax of Picea abies needles and in sediment samples from various geographical locations, including the Harney River in Florida and Lake Kivu in the East African Rift Valley. Its presence in these environments suggests potential roles in ecological and biochemical research applications, particularly in studies related to plant metabolism and natural wax formations. -
Endogenous Metabolite
Glucoberteroin is an endogenous metabolite derived from the glucosinolate family, isolated from Degenia velebitica. It primarily functions by inhibiting protein glycosylation and carbonylation, leading to a reduction in carbonyl protein production. This compound has potential applications in research focused on skin aging and the molecular mechanisms underlying age-related changes in skin biology.
