PAT-494 is an autotaxin (ATX) inhibitor that demonstrates significant anti-lyso-phosphatidic acid (LPA) activity in biochemical and plasma assays. This compound effectively reduces LPA levels in rat plasma upon oral administration, making it a valuable tool for studying LPA-related biological processes. Structural and activity studies have revealed a novel binding mode of PAT-494, allowing it to effectively occupy the hydrophobic pockets and channels of ATX, thereby providing insights into ATX modulation in various pathological conditions.
PAT-494 is an autotaxin (ATX) inhibitor that demonstrates significant anti-lyso-phosphatidic acid (LPA) activity in biochemical and plasma assays. This compound effectively reduces LPA levels in rat plasma upon oral administration, making it a valuable tool for studying LPA-related biological processes. Structural and activity studies have revealed a novel binding mode of PAT-494, allowing it to effectively occupy the hydrophobic pockets and channels of ATX, thereby providing insights into ATX modulation in various pathological conditions.
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