Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Pantoic acid is an endogenous metabolite involved in the biosynthesis of D-pantothenic acid, a crucial component of coenzyme A. This compound plays a significant role in various metabolic pathways, including fatty acid synthesis and energy metabolism. Pantoic acid is useful for research focused on metabolic processes and the regulation of coenzyme A levels in biological systems. -
Endogenous metabolites
Indole-3-lactate-O-β-D-glucopyranoside is an endogenous metabolite that functions as a plant growth regulator. It plays a critical role in mediating plant growth and development through hormone signaling pathways. This compound is useful in research applications focused on plant biology, including studies on growth regulation and metabolic profiling. -
Endogenous Metabolite
NCX 1000 is a liver-specific nitric oxide (NO) donor compound derived from ursodeoxycholic acid (UDCA). This endogenous metabolite facilitates the release of nitric oxide, which plays a crucial role in various physiological processes, particularly in liver function. NCX 1000 is primarily used in research applications focusing on hepatic biology, NO signaling pathways, and the investigation of liver-related diseases. -
Endogenous Metabolite
(±)-γ-Tocopherol is an endogenous metabolite that plays a critical role in various biological processes. It exhibits potent antioxidant properties and has been shown to influence cell signaling pathways that may be relevant in the context of cancer research. This compound is particularly useful for investigating its potential role in the pathogenesis of prostate and endometrial cancers. -
Endogenous Metabolite
aPKC-IN-2 is a selective inhibitor of atypical protein kinase C (aPKC), targeting its activity to modulate cellular signaling pathways. This compound effectively reduces vascular endothelial permeability in both in vitro and in vivo models, demonstrating significant actions against vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF). aPKC-IN-2 interferes with NFκB-mediated gene transcription, highlighting its role in regulating inflammatory responses. The EC50 value of aPKC-IN-2 is in the low nanomolar range, laying the groundwork for advancing small molecule aPKC inhibitors in therapeutic research. -
Endogenous Metabolite
3β,7α-Dihydroxycholest-5-enoic acid is an endogenous metabolite involved in cholesterol metabolism. This compound plays a role in bile acid synthesis and may influence lipid homeostasis. It is useful in research applications focused on lipid biology, metabolic disorders, and cholesterol-related diseases. -
Endogenous Metabolite
MAGL-IN-3 is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 34.1 nM. This compound effectively reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release in Neuro2a cells at a concentration of 1 μM. Additionally, administration of MAGL-IN-3 at a dosage of 10 mg/kg significantly elevates levels of 2-arachidonoyl glycerol in mouse brain, making it a valuable tool for studying endocannabinoid signaling and neurobiological processes. -
Endogenous Metabolite
1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol that features linoleic acid side chains at the sn-1 and sn-2 positions, targeting various metabolic pathways. It plays a significant role as a component of phosphatidic acid in rat liver mitochondria and spinach chloroplast membranes. Additionally, this compound is identified as a potential biomarker for predicting preeclampsia in early pregnancy, making it relevant for studies on pregnancy-related conditions and lipid metabolism. -
Endogenous Metabolite
Acetonitrile-15N is a stable isotope-labeled compound primarily utilized as an endogenous metabolite in metabolic research. With applications in biolabeling experiments, it facilitates the tracking of metabolic pathways and elucidation of chemical reaction mechanisms within various organisms. Additionally, Acetonitrile-15N is instrumental in environmental science, aiding in the study of pollutant migration and transformation processes. -
Endogenous Metabolite
Biotin sodium, an endogenous metabolite, functions as a critical coenzyme for five carboxylases in humans. It plays a vital role in various metabolic processes, including fatty acid synthesis, isoleucine and valine metabolism, and gluconeogenesis. This water-soluble B vitamin is essential for cell growth and the metabolism of fats and amino acids, making it valuable in biochemical research and applications related to metabolism and nutrition. -
Endogenous Metabolite
Methyl cyclohexanecarboxylate acts as an endogenous metabolite in various biological systems. This compound plays a role in metabolic pathways and can be utilized in research focusing on metabolomics and biochemical analysis. Its study may provide insights into metabolic regulation and physiological functions. -
Endogenous Metabolite
Jalapinolic acid (11-Hydroxyhexadecanoic acid; 11-Hydroxypalmitic acid) is an endogenous metabolite with potential roles in lipid metabolism and cellular signaling. This hydroxyhexadecanoic acid has been shown to influence various biological processes, making it valuable for research into metabolic disorders and the study of fatty acid derivatives. Its unique biochemical properties facilitate investigations into its effects on cellular functions and metabolic pathways. -
Endogenous Metabolite
Estriol 16α-(β-D-glucuronide) is an endogenous metabolite primarily involved in estrogen metabolism and is prevalent in urine. It serves as a valuable biomarker in pregnancy-related research, aiding in the assessment of fetal development and maternal health. This compound is essential for studies investigating hormonal changes during gestation and may provide insights into various pregnancy complications. -
Endogenous Metabolite
(±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) formed through CYP450-mediated metabolism. This compound serves as an endogenous metabolite and is involved in various cellular processes, including inflammation and cellular signaling. It is utilized in research to study the biochemical pathways of omega-3 fatty acids and their effects on physiological functions. -
Endogenous Metabolite
GSK 1842799 hydrochloride is a selective agonist for the S1P1 receptor, exhibiting potent agonistic activity with notable selectivity over the S1P3 receptor. This compound demonstrates favorable oral bioavailability and is rapidly converted to its active phosphorylated form. In vivo studies reveal that GSK 1842799 hydrochloride significantly reduces blood lymphocyte counts after oral administration. Additionally, it has shown efficacy comparable to FTY720 in the mouse EAE model of multiple sclerosis, making it a valuable tool for research in immunology and neurodegenerative diseases. -
Endogenous Metabolite
Fenamidone is a potent agricultural fungicide that primarily targets mitochondrial respiratory complex II. It exhibits high biological activity against a range of plant pathogens, leading to effective disease control in various crops. Fenamidone is valuable in research applications focused on plant physiology, fungicide resistance mechanisms, and metabolic pathways in fungi. -
Endogenous Metabolite
SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1, exhibiting anxiolytic, antidepressant, and appetite-suppressant properties. In preliminary animal studies, SNAP-7941 demonstrated significant biological activity and the ability to inhibit MCH-induced drinking behavior, highlighting its potential for research in neuropharmacology and metabolic disorders. This compound serves as a valuable tool for investigating the role of MCH1 in various physiological processes. -
Endogenous Metabolite
1-Deoxysphingosine is an endogenous metabolite that acts as a deoxy-sphingoid base, characterized by a (4E) double bond in its structure. This compound is notably elevated in the lymphoblasts of individuals with hereditary sensory neuropathy type 1 (HSAN1), highlighting its potential relevance in neuropathic disorders. It is produced through the catabolism of 1-deoxyceramide, catalyzed by the ceramidase enzyme, making it a valuable target for research in sphingolipid metabolism and related cellular processes. -
Endogenous Metabolite
16-Ketoestradiol is an endogenous metabolite of estrone, a naturally occurring estrogen. It plays a critical role in the regulation of estrogenic activity within the body, influencing various physiological processes. This compound is important for research applications related to hormonal studies and the exploration of estrogen-related disorders. -
Endogenous Metabolite
Ocaphane is an endogenous metabolite with demonstrated potential as an antitumor agent. It exhibits significant cytotoxic activity against a variety of animal tumor models, making it a valuable tool for cancer research. This compound can be utilized to investigate tumor biology and evaluate therapeutic strategies in preclinical studies. -
Endogenous Metabolite
Kahalalide A is an anti-mycobacterial compound derived from the marine mollusk Elysia rufescens, targeting various microbial pathogens. This endogenous metabolite exhibits significant antimicrobial activity, making it a valuable candidate for research in natural product pharmacology. Its unique structure and bioactivity have garnered interest for potential therapeutic applications in combating infectious diseases. -
Endogenous Metabolite
p60 (217–225) is a subdominant epitope derived from Listeria monocytogenes, recognized by H-2Kd MHC class I molecules. This peptide plays a crucial role in the immune response to Listeria infection, facilitating T cell recognition and activation. p60 (217–225) is essential for studying antigen presentation and T cell immunity in infectious disease research and vaccine development. -
Endogenous Metabolite
ISQ-1 hydrochloride is an isoquinolinone compound that functions as an inhibitor of the IKur potassium channel. It demonstrates potential to influence cardiac electrophysiology by modulating arrhythmic activity in atrial tissues. This reagent is primarily utilized in research focused on cardiac rhythm disorders and electrophysiological studies of heart functions. -
Endogenous Metabolite
N4-Acetylsulfamerazine is a sulfonamide derivative that primarily targets endogenous metabolites. It exhibits antibiotic activity, specifically inhibiting bacterial growth through interference with folic acid synthesis. This compound is valuable for studying sulfonamide pharmacology and understanding metabolic pathways in microbial resistance. Its applications extend to research in infectious diseases and pharmacokinetics. -
Endogenous Metabolite
Altertoxin II is an endogenous metabolite derived from Alternaria alternata, known for its mutagenic properties. It exhibits mutagenicity in various strains of Salmonella typhimurium, including TA98, TA100, and TA1537, both in the presence and absence of metabolic activation. This compound serves as a valuable tool for investigating the mechanisms of mutagenesis associated with mycotoxins, contributing to understanding their impact on genetic material. -
Endogenous metabolite
4-Methyltridecane is an endogenous metabolite that is released by cabbage root flies (Delia radicum) during feeding. This volatile compound serves as a significant cue for the parasitoid bee Trybliographa rapae, aiding in the locational identification of its host. Additionally, 4-Methyltridecane can be utilized as a specific marker for detecting root damage in turnips (Brassica rapa subsp. rapa), making it valuable in studies of plant-insect interactions and pest management. -
Endogenous Metabolite
ML395 is a potent and selective allosteric inhibitor of phospholipase D2, demonstrating significant antiviral activity. With a cellular IC50 value for PLD2 of 360 nM and an IC50 value for PLD1 exceeding 30,000 nM, it exhibits remarkable selectivity. ML395 possesses favorable pharmacokinetic profiles in vitro and superior physicochemical properties compared to other phospholipase inhibitors. Its efficacy has been validated in cell-based assays against various strains of the influenza virus, including H1, H3, H5, and H7, making it a valuable tool for antiviral research. -
Endogenous Metabolite
C20 Sphingomyelin (d18:1/20:0) is a naturally occurring sphingolipid that targets cellular membranes and plays a critical role in various biological processes. It is associated with increased levels in the hippocampus of streptozotocin-induced diabetic rats, showing a positive correlation with insulin resistance in obese human subjects. Additionally, C20 Sphingomyelin (d18:1/20:0) is elevated in the liver of mouse models of Niemann-Pick C1 disease, a neurodegenerative disorder characterized by lysosomal storage of cholesterol and sphingolipids. This compound serves as a valuable tool for studying metabolic disorders and neurodegenerative diseases. -
Endogenous Metabolite
YM-355179 fumarate is a selective antagonist of the C-C chemokine receptor type 3 (CCR3), targeting eosinophil-related allergic inflammatory diseases. This compound effectively inhibits the binding of CCL11 and CCL5 to CCR3-expressing cells, exhibiting IC50 values of 7.6 nM and 24 nM, respectively. Functional assays demonstrate that YM-355179 fumarate inhibits CCL11-induced intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation, with IC50 values of 8.0 nM, 24 nM, and 29 nM, respectively. This makes it a valuable tool for researchers studying allergic inflammation and related conditions. -
Endogenous Metabolite
GS-9851 is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B), making it a valuable tool for researching HCV infection. This compound exhibits favorable tolerability, particularly in patients with initial HCV genotype 1 infections. Due to its pharmacokinetic profile, GS-9851 is rapidly eliminated from the body, with a half-life of approximately one hour. -
Endogenous Metabolite
Hydroxythiohomosildenafil is an endogenous metabolite of Sildenafil that plays a role in modulating erectile function. This compound is useful for investigating the pharmacokinetics and metabolic pathways associated with erectile dysfunction. Its biological activity provides insights into the mechanisms underlying penile erection and helps to evaluate therapeutic interventions in related vascular disorders. -
Endogenous Metabolite
Drimentine B is a terpenylated diketopiperazine that acts on endogenous metabolites. Demonstrating significant anticancer activity, it inhibits the proliferation of NS-1 murine β lymphocyte myeloma cells by 41% and 59% at concentrations of 50 and 100 μg/mL, respectively. This compound is valuable for research applications focusing on cancer biology and the exploration of novel therapeutic agents. -
Endogenous Metabolite
Tetranor-12(S)-HETE is an endogenous metabolite derived from the β-oxidation of 12(S)-HETE via peroxisomal metabolism in various tissues. This compound serves as a potential biomarker for psoriasis, facilitating research into the inflammatory processes associated with this skin condition. Its role in fatty acid metabolism makes it valuable for studies investigating related metabolic and inflammatory disorders. -
Endogenous Metabolite
5,6-Dihydro-5-methyluracil-d6 is a deuterium-labeled derivative of 5,6-Dihydro-5-methyluracil, which serves as an endogenous metabolite and an intermediate in the catabolism of thymine. This compound, also known as Dihydrothymine, is derived from both animal and plant sources. Elevated levels of 5,6-Dihydro-5-methyluracil may exhibit toxicity, making it relevant for research into metabolic pathways and potential toxicological studies. -
Endogenous Metabolite
FR 106969 is a potent platelet activating factor antagonist that exhibits anti-inflammatory properties. This compound is primarily utilized for its ability to mitigate inflammatory responses, making it valuable in the study of inflammation-related diseases. Research indicates that FR 106969 may offer significant inhibitory effects on various inflammatory pathways, contributing to its potential therapeutic applications in conditions characterized by excessive inflammation. -
Endogenous Metabolite
Xylamidine tosylate is a serotonin inhibitor that modulates the serotonin system and exhibits reproductive activity. This compound is instrumental in investigating reproductive processes and their underlying mechanisms. Xylamidine tosylate serves as a valuable tool in experimental research focused on serotonin's role in reproductive biology. -
Endogenous Metabolite
D-Ribofuranose serves as an endogenous metabolite that plays a crucial role in cellular metabolism. It is primarily involved in the synthesis of nucleotides and nucleic acids. Research applications include studies related to Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl-CoA Dehydrogenase Deficiency, providing insights into metabolic pathways and associated disorders. -
Fungal Metabolite
Gliorosein is a fungal metabolite derived from Gliocladium, functioning primarily as an isomeric variant of quinol. It exhibits distinct ultraviolet absorption characteristics, differentiating it from related compounds. This unique profile makes Gliorosein valuable for biological research applications, particularly in the study of fungal metabolism and ecological interactions. -
Endogenous Metabolite
Endopeptidase-IN-1 is a potent inhibitor of endopeptidase activity, targeting endogenous metabolites to regulate proteolytic processes. Its biological activity is crucial for research focused on protein processing, cellular signaling pathways, and the modulation of metabolic diseases. This compound is a valuable tool for investigating the role of endopeptidases in physiological and pathological conditions. -
Endogenous Metabolite
YM-75440 is an orally active inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound demonstrates significant biological activity in modulating lipid metabolism, making it useful for research on metabolic disorders and cardiovascular diseases. Its ability to inhibit squalene synthesis positions YM-75440 as a valuable tool for studying cholesterol-related pathways and potential therapeutic interventions. -
Endogenous Metabolite
Wofapyrin, a derivative of Rheumopyrin, primarily acts as an antipyretic and anti-inflammatory agent. This compound has demonstrated significant biological activity in reducing lesion volume, positioning it as a valuable reagent in studies focused on inflammation and fever regulation. Its application is pertinent for researchers investigating metabolic pathways and therapeutic interventions in inflammatory conditions. -
Endogenous Metabolite
alpha-RA-F (α-RA-F) is an endogenous metabolite that promotes collagen synthesis while reducing the expression levels of matrix metalloproteinases (MMPs). Its ability to enhance collagen production in human fibroblasts without cytotoxicity makes α-RA-F a valuable tool for research in tissue regeneration and skin health. This compound holds significant potential for applications in both pharmaceutical and cosmetic industries, particularly in the regulation of collagen dynamics and extracellular matrix remodeling. -
Endogenous Metabolite
R-(-)-Phencynonate hydrochloride is a muscarinic receptor antagonist that exhibits anticholinergic activity. This compound serves as a significant endogenous metabolite, making it integral for investigations related to its concentration in human plasma within medical research contexts. R-(-)-Phencynonate has been effectively analyzed using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), demonstrating excellent specificity and linearity for precise quantification. -
Endogenous Metabolite
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid featuring stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. This compound is generated through the oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by the enzyme 15-lipoxygenase in activated human peripheral mononuclear cells. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE serves as an endogenous metabolite, providing valuable insights into lipid metabolism and cell signaling pathways in various biological research applications. -
Endogenous Metabolite
ts-SA is a potent carbonic anhydrase (CA) inhibitor that demonstrates inhibitory activity against seven human CA homologues. It effectively binds to the Zn(II) ion in the enzyme's active site in its deprotonated form, with its organic structure extending into the enzyme cavity, facilitating interactions with amino acid residues and water molecules. With low nanomolar inhibitory activity, ts-SA serves as a multi-target CA inhibitor, making it valuable for research applications in enzymatic regulation and metabolic studies. -
Endogenous Metabolite
DY3002 is a highly selective and potent EGFR inhibitor specifically designed to target T790M-mutated variants associated with non-small cell lung cancer. This compound demonstrates a remarkable inhibitory effect on EGFR T790M mutants with an IC50 of 0.71 nM, while exhibiting significantly reduced activity against wild-type EGFR (IC50 = 448.7 nM). In cellular assays, DY3002 shows an IC50 of 0.037 μM against H1975 cells, indicating enhanced biological efficacy. Additionally, DY3002 maintains an extraordinary selectivity index (SI = 632.0) and does not induce hyperglycemia, making it a promising candidate for further research in overcoming drug resistance in cancer therapy. -
Endogenous Metabolite
Ro 31-1118 Free Base is an endogenous metabolite that exhibits weak antihypertensive activity. It has been shown to reduce heart rates and blood pressure following exercise at various doses, demonstrating linear pharmacokinetics within the 10-80 mg range. Notably, Ro 31-1118 does not significantly affect diastolic blood pressure and shows minimal adverse effects, making it a valuable compound for studies related to cardiovascular function and blood pressure regulation. -
Endogenous Metabolite
1,3-Dioleoyl-2-lauroyl glycerol is an endogenous metabolite recognized for its role in the triglyceride composition of human milk. This compound can be analyzed using liquid chromatography-mass spectrometry, facilitating targeted studies of lipid metabolism and nutritional research. Its characterization contributes to the understanding of dietary fats and their influence on human health. -
Fungal Metabolite
Burnettramic acid A aglycone is a fungal metabolite derived from Aspergillus burnettii, exhibiting potential antimicrobial properties. This compound may play a significant role in research focused on antifungal activity and the exploration of secondary metabolites in fungi. Its unique chemical structure and biological functions make it a valuable reagent for studies in microbiology and natural product chemistry. -
Endogenous Metabolite
11β-13,14-Dihydro-15-keto Prostaglandin F2α is an endogenous metabolite that serves as a derivative of 13,14-Dihydro-15-keto PGF2α. This compound plays a significant role in various biological processes, particularly in pregnancy-related research. Its biological activity may facilitate the investigation of prostaglandin pathways and their implications in reproductive health and pregnancy maintenance.
