Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
PMX 53 monoacetate is a potent orally active antagonist of CD88 (C5aR), primarily inhibiting C5a-induced neutrophil myeloperoxidase release and chemotactic activity. It demonstrates an IC50 of 20 nM for myeloperoxidase release and 75 nM for chemotaxis, making it an effective tool for studying neutrophil responses. Additionally, PMX 53 monoacetate acts as an agonist of MrgX2, further broadening its potential applications in research involving inflammatory processes and pain signaling pathways. -
Endogenous Metabolites
Epoxide hydrolase is an enzyme that catalyzes the hydrolysis of epoxides, converting them into diols. This enzyme is crucial for the metabolism of endogenous metabolites, including environmental pollutants and lipids, thereby facilitating detoxification and modulating inflammatory responses and cardiovascular health. Furthermore, epoxide hydrolase is applicable in asymmetric catalytic reactions, particularly in the asymmetric ring-opening of epoxides, enabling the synthesis of chiral drug molecules for pharmaceutical research. -
Endogenous Metabolite
3-Benzylidenecamphor, an endogenous metabolite, serves primarily as a UV absorber with strong photostability and antioxidant properties. This compound is effective in protecting skin from UV damage and is frequently incorporated into sunscreen formulations. Additionally, 3-Benzylidenecamphor enhances the shelf life and safety of cosmetic products, making it valuable for research into skincare and beauty applications. -
Endogenous Metabolite
Tocol is a synthetic derivative of vitamin E that functions as an endogenous metabolite. Unlike (±)-α-tocopherol, Tocol does not inhibit retinol-induced erythrocyte hemolysis or enhance the microviscosity of rat liver phosphatidylcholine liposomes. This unique profile makes Tocol a valuable tool for research focused on cellular membrane dynamics and vitamin E metabolism. Its distinct biological activity may offer insights into the mechanistic roles of vitamin E derivatives in various physiological contexts. -
Endogenous Metabolite
Sandosaponin A is a saponin that primarily targets human recombinant aldehyde reductase (hAKR1B1), exhibiting notable inhibitory activity. This compound effectively inhibits the reduction of both l-idose and 4-hydroxynonenal, highlighting its role in distinguishing between different aldehyde reductase inhibitors in complex mixtures. The mechanism of inhibition by Sandosaponin A is thought to involve its interaction with diverse substrates, making it a valuable tool for research focused on metabolic pathways and enzyme regulation. -
Endogenous Metabolite
(+)-Norgestrel is a synthetic progestin that primarily targets progesterone receptors to regulate reproductive hormone activity. It is widely utilized in contraceptive formulations and plays a significant role in managing hormonal levels during menopause. Research applications include studies on reproductive health, hormonal therapies, and the mechanism of action of progestins in various biological systems. -
Endogenous Metabolite
D-Xylonic acid is an endogenous metabolite involved in the interconversion of pentose and glucuronate metabolites. This compound serves as an important intermediate in carbohydrate metabolism and is relevant in studies focused on metabolic pathways. Its biological activity influences various physiological processes, making it valuable for research in biochemistry and metabolic disease. -
Endogenous Metabolite
Glyphosate-13C,15N is a stable isotope-labeled form of glyphosate, incorporating 13C and 15N. This compound serves as an endogenous metabolite and is utilized in metabolic studies to trace absorption, distribution, and metabolism in biological systems. Its unique isotopic labeling facilitates advanced analytical techniques, including mass spectrometry, for investigating the pharmacokinetics and environmental interactions of glyphosate. -
Endogenous Metabolite
Badione A is a naturally occurring metabolite derived from the fungus Xerocomus badius, known for its ability to form stable salts with potassium ions. This compound exhibits potential biological activity that may be valuable in metabolic studies and the exploration of ion interactions in biological systems. Its unique properties make Badione A a useful reagent for research applications in the fields of biochemistry and pharmacology. -
Endogenous Metabolite
Aeruginosin B is a phenazine pigment that functions as an endogenous metabolite, primarily derived from Pseudomonas aeruginosa. This compound demonstrates antimicrobial activity and plays a role in the regulation of various biological processes. Aeruginosin B is often utilized in research to study microbial interactions, pathogenicity, and the biochemical pathways associated with phenazine derivatives. -
Endogenous Metabolite
Ethyl glutamate is an amino acid derivative that acts as an endogenous metabolite, promoting cell growth and proliferation. This compound is valuable in research related to cellular biology and metabolic pathways, providing insights into amino acid metabolism and its effects on cellular processes. Its role in supporting cell viability makes it a useful tool for studies investigating growth factors and metabolic regulation in various biological contexts. -
Endogenous Metabolite
Lipoxin A5 is an endogenous metabolite derived from eicosapentaenoic acid, predominantly found in pig white blood cells. It exhibits contractile activity on guinea pig lung parenchymal strips, demonstrating a force comparable to that of Lipoxin A4 and Lipoxin B4. However, unlike Lipoxin A4 and Lipoxin B4, Lipoxin A5 does not induce vasodilation in aortic smooth muscle. This compound is valuable for research into inflammatory processes and the pharmacological modulation of respiratory function. -
Endogenous Metabolite
8(Z)-Eicosenoic acid is a cis-unsaturated free fatty acid that serves as an endogenous metabolite. This 20-carbon chain fatty acid potentiates acetylcholine receptor channel currents without causing depression and enhances the phosphorylation of protein kinase C epsilon (PKCε) substrates in Xenopus oocytes. It represents approximately 6% of the fatty acid composition in seed oil derived from Bursera collina, making it significant for studies in fatty acid metabolism and receptor pharmacology. -
Endogenous Metabolite
OT-730 is a selective beta-blocker prodrug that targets endogenous metabolites involved in ocular disease pathways. This compound is primarily utilized in research focused on understanding the mechanisms of ocular disorders and the potential therapeutic interventions therein. Its unique pharmacological profile makes it a valuable tool for investigating the role of beta-adrenergic signaling in eye health and disease. -
Endogenous Metabolite
Bhimanone is an endogenous metabolite that exhibits bioinactive properties. Isolated from the genus Streptomyces, this tetralone may serve as a valuable reference compound in metabolic studies. Its structural characteristics can aid in the investigation of biosynthetic pathways and natural product chemistry. -
Endogenous Metabolite
Furan fatty acid F5 (12,15-epoxy-13-methyl-12,14-eicosadienoic acid) is an endogenous metabolite originally isolated from northern pike (Esox lucius). This compound has been shown to exhibit alterations in liver levels during starvation in cod, indicating its potential role in metabolic pathways. Furan fatty acid F5 can be used in research applications aimed at understanding lipid metabolism and the biochemical responses to nutritional stressors. -
Endogenous Metabolite
(E/Z)-Linoleoyl-CoA is an endogenous metabolite that serves as a substrate for analyzing the specificity and kinetics of acyl-CoA. Its unique ability to substitute for different substrates allows for the investigation of amino acid substitutions, which can impact the reactivity with various desaturases. Research involving (E/Z)-Linoleoyl-CoA enhances the understanding of substrate specificity in mammalian fatty acid desaturases and facilitates the development of methods for the efficient production of valuable fatty acids. -
Endogenous Metabolite
Camylofin dihydrochloride is an antispasmodic agent primarily targeting smooth muscle activity. It is effective in alleviating smooth muscle spasms, making it useful in managing conditions such as labor-related discomfort and ulcerative colitis. Additionally, the content of camylofin dihydrochloride in pharmaceutical formulations can be quantitatively analyzed using gas chromatography, facilitating quality control and research applications in therapeutic studies. -
Endogenous Metabolite
N-Acetylciprofloxacin is the metabolic product of the antibiotic Ciprofloxacin. This compound is of interest in studies investigating the pharmacokinetics and metabolic pathways of fluoroquinolones. Its biological activity may offer insights into the safety, efficacy, and potential side effects of Ciprofloxacin in therapeutic applications. Research involving N-Acetylciprofloxacin can aid in understanding antibiotic resistance mechanisms and tissue distribution in various biological systems. -
Endogenous Metabolite
Eicosapentaenoyl chloride is a derivative of eicosapentaenoic acid that serves as a fatty acyl chloride. This compound is utilized in the synthesis of fatty acid conjugates to improve the lipophilicity and cellular permeability of various bioactive molecules, including (–)-epigallocatechin gallate and salicylic acid. Its application is significant in enhancing the bioavailability and effectiveness of therapeutic agents in chemical research. -
Endogenous Metabolite
(Z)-Methyl heptadec-10-enoate is an ester derived from cis-10-heptadecenoic acid and functions as an endogenous metabolite. This compound exhibits key biological activities related to fatty acid metabolism and is often utilized in studies involving biodiesel components. Its specific structure and properties make it valuable for research applications in lipid biochemistry and metabolic profiling. -
Endogenous Metabolite
N-Methylarachidonamide is an analog of the endogenous cannabinoid anandamide, primarily targeting the central cannabinoid receptor (CB1). This compound exhibits a binding affinity with a Ki value of 60 nM for CB1, influencing various physiological processes. Additionally, it effectively inhibits rat glial gap junction cell-cell communication by 100% at a concentration of 50 μM. As such, N-Methylarachidonamide is a valuable tool for research exploring cannabinoid receptor signaling and its implications in neurobiology and related fields. -
Endogenous Metabolite
DU717 is an antihypertensive agent that targets endogenous metabolites to modulate blood pressure regulation. It is utilized in research focused on cardiovascular health and the physiological pathways involving blood pressure homeostasis. Its biological activity may provide insights into treatments for hypertension and related cardiovascular disorders. -
Endogenous Metabolite
Tuftsin diacetate is a tetrapeptide that acts as a potent activator of macrophages and microglia. It enhances immune responses and plays a critical role in modulating inflammation. This compound is valuable for research applications focused on innate immunity, neuroinflammation, and the study of macrophage biology. -
Endogenous Metabolite
SU200 is a TRPV1 agonist that modulates intracellular calcium ion concentrations. It induces distinct calcium ion response patterns, displaying notable reactivity and peak efficacy. The effects of SU200 exhibit varying degrees of response delay and variability across different cell types. This compound offers potential avenues for pharmacological development and further research into calcium signaling pathways. -
Endogenous Metabolite
RO5101576 is a potent antagonist of the leukotriene B4 (LTB4) receptor, effectively inhibiting LTB4-induced calcium mobilization and chemotaxis in human neutrophils. This compound demonstrates significant reduction of LTB4-induced pulmonary eosinophilia in guinea pigs, and it inhibits allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy similar to that of budesonide. Notably, RO5101576 does not affect LPS-induced neutrophilia in guinea pigs or cigarette smoke-induced neutrophilia in mice and rats. Its favorable performance in toxicology studies indicates good tolerability. -
Endogenous Metabolite
(R)-Pioglitazone-d1 is a deuterated form of the R-enantiomer of pioglitazone, primarily targeting mitochondrial function and exhibiting non-steroidal anti-inflammatory properties. This compound is significant for research applications related to non-alcoholic steatohepatitis (NASH) treatment, as it supports glucose modulation and enhances metabolic activity. Its stable isotopic labeling enables detailed metabolic studies and mechanistic investigations in related biological systems. -
Endogenous Metabolite
l-Primaquine is an antimalarial compound primarily targeting the elimination of Plasmodium species. It exhibits significant activity in the prevention and treatment of malaria infections, as well as providing therapeutic benefits against Pneumocystis jiroveci pneumonia. This endogenous metabolite is valuable in both clinical and research settings for studying malaria and related diseases. -
Fungal Metabolite
Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate is a fungal metabolite that acts as a target for various biological interactions. This compound exhibits significant antifungal activity, making it a valuable reagent for research in microbiology and pharmacology. It is particularly useful for studies focused on fungal infections and the exploration of novel therapeutic agents derived from natural sources. -
Endogenous Metabolite
Lead salicylate is an endogenous metabolite that primarily acts as an anti-inflammatory agent. Its biological activity includes inhibition of cyclooxygenases (COX-1 and COX-2), which are key enzymes involved in the synthesis of prostaglandins. This compound is often used in research to investigate mechanisms of inflammation and the modulation of pain pathways, contributing to a better understanding of inflammatory diseases and potential therapeutic strategies. -
Endogenous Metabolite
VU0415374 is a positive allosteric modulator of the mGlu4 receptor, enhancing its activity and enabling precise manipulation of physiological responses. This compound exhibits high selectivity, making it a valuable tool for investigating the role of mGlu4 in conjunction with other mGlu receptor systems. Its refined properties position VU0415374 as a significant candidate for experiments requiring high spatial and temporal precision in mGlu4 research. -
Fungal Metabolite
6-Ethyl-2,7-dimethoxyjuglone is a fungal metabolite known for its biological activity against various pathogens. This compound has been isolated from freshwater fungi and exhibits potential antifungal properties. It serves as a valuable tool for research applications focusing on fungal biology and the discovery of new antifungal agents. -
Endogenous Metabolite
1,2-Dipentadecanoyl-rac-glycerol is an endogenous metabolite that primarily targets cellular lipid metabolism. This compound has been studied for its role in insulin-mediated regulation of 1,2-diacylglycerol levels in rat hearts, highlighting its potential implications in cardiac contractility. Its distinct fatty acid composition may provide insights into the metabolic pathways influenced by insulin, making it a valuable tool for research in cardiovascular physiology and metabolic disorders. -
Endogenous Metabolite
4-Acetylaminobutanal is an endogenous metabolite involved in the urea cycle. It serves as an important intermediate in amino acid metabolism and is significant for studying metabolic pathways and related disorders. Researchers can utilize 4-Acetylaminobutanal to explore its role in metabolic processes and the implications of urea cycle dysregulation in various biological systems. -
Endogenous Metabolite
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol functions as an endogenous metabolite and a critical component of cell membranes. This phosphoinositol plays a vital role in various cellular processes, including signal transduction and membrane dynamics. Its study is essential for understanding lipid metabolism, cellular signaling pathways, and membrane structure in biological research. -
Endogenous Metabolite
GYKI-16084 is an endogenous metabolite that can be isolated from canine and rodent urine. This compound exhibits potential relevance in studying benign prostatic hyperplasia, contributing to our understanding of urological health and disorders. Its utility in research makes it a valuable tool for exploring mechanisms underlying prostate-related conditions. -
Endogenous Metabolite
A 854777 is a homologous piperazine derivative that targets endogenous metabolites, exhibiting notable anti-inflammatory activity. This compound possesses non-classical immunosuppressive properties, making it valuable for studies focused on modulating immune responses. Its applications include research into diseases characterized by inflammation, providing insights into potential therapeutic interventions. -
Endogenous Metabolite
9-cis-Vitamin A palmitate is an endogenous metabolite and a 9-cis isomer derived from vitamin A palmitate, commonly found in dietary sources such as corn flakes. This compound exhibits approximately 26% of the biological activity compared to all-trans-vitamin A palmitate, the predominant and most active form of vitamin A. It serves as a valuable reagent for research focused on vitamin A metabolism, retinoid signaling pathways, and the development of therapies targeting retinoid-related disorders. -
Endogenous Metabolite
OMDM-3 is a selective inhibitor of anandamide cellular uptake (ACU), exhibiting a Ki value of 16.6 μM. This compound is metabolically stable, making it suitable for studies investigating the role of anandamide in cannabinoid signaling and endocannabinoid system modulation. OMDM-3 can be utilized in research applications focused on pain management, neuroprotection, and the exploration of lipid signaling pathways. -
Endogenous Metabolite
DF 461 is a selective sterol synthase inhibitor that effectively impairs cholesterol biosynthesis. Demonstrating high specificity for liver tissue, DF 461 significantly reduces cholesterol synthesis in rat liver models. This compound has also been shown to lower plasma lipid levels in repeated dosing studies in non-rodent species, making it valuable for research applications related to lipid metabolism and cardiovascular health. -
Endogenous Metabolite
UCM765 is a selective ligand for the MT2-type melatonin receptor, exhibiting hypnotic, analgesic, and anxiolytic activities. Its partial agonist properties make it a valuable compound for pharmacological research. Structural modifications of UCM765 can enhance its water solubility and metabolic stability, potentially increasing its bioavailability. The compound's biological effects have been substantiated in rat models, indicating its promise for further exploration in pharmacological studies. -
Endogenous Metabolite
Chondrosamine, 6-phosphate is an endogenous metabolite that plays a critical role in amino sugar metabolism. This amino sugar phosphate compound is involved in multiple biochemical pathways related to sugar metabolism. Its relevance in studying cellular metabolism and synthetic pathways makes it a valuable reagent for research applications in biochemistry and molecular biology. -
Endogenous Metabolite
TRIA-662 iodide, also known as 1-Methylnicotinamide chloride, is an endogenous metabolite that primarily targets pathways associated with inflammation and thrombosis. This compound exhibits notable antithrombotic and anti-inflammatory activities, making it valuable for research applications focused on cardiovascular health and inflammatory diseases. Its role in cellular metabolism further highlights its potential in studying metabolic dysregulation and related disorders. -
Endogenous Metabolite
β-Nicotinamide adenine dinucleotide reduced dipotassium (NADH) functions primarily as a key coenzyme in redox reactions. It serves as a donor of ADP-ribose units in ADP-ribosylation processes and is a precursor to cyclic ADP-ribose. Additionally, NADH plays a vital role in cellular energy metabolism, contributing to pathways such as glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle, making it essential for various research applications in metabolic studies and cellular function analysis. -
Endogenous Metabolite
IST-622 is an endogenous metabolite exhibiting significant anti-tumor activity through the inhibition of cancer cell growth. It demonstrates potent growth inhibitory effects against various mouse tumor models, including P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, and Colon 26 and 38 adenocarcinomas. Additionally, IST-622 is effective in human tumor xenograft models, notably large cell lung carcinoma and gastric adenocarcinoma. In vitro studies reveal an IC50 for P388 leukemia that is over 20 times lower than conventional treatments, underscoring its potential as a therapeutic agent in oncology research. -
Endogenous Metabolite
GCN2iB acetate is a selective inhibitor of the GCN2 kinase, primarily targeting the Gcn2 signaling pathway. It enhances the phosphorylation of eIF2, leading to increased expression of Atf4, particularly in Gcn2 mutants with specific alterations in regulatory regions or kinase domain substitutions. This compound is valuable for studying cellular responses to nutritional stress and has potential applications in cancer research, specifically in sensitizing cancer cells with low levels of aspartate synthetase to the anti-leukemic agent L-aspartase. -
Endogenous Metabolite
1-Myristoyl-2-(4-nitrophenylsuccinyl)-sn-glycero-3-phosphocholine is a synthetic phospholipid that primarily targets cell membranes to inhibit cell proliferation. This compound serves as an effective carrier to enhance the bioavailability of various therapeutic agents. Additionally, it is an important tool in cell membrane research, facilitating the study of cell signal transduction pathways. -
Endogenous Metabolite
GNE-783 is a selective checkpoint kinase 1 (CHK1) inhibitor that plays a pivotal role in modulating the cell cycle response to DNA damage. By inactivating S-phase and G2-phase checkpoints, it enhances the efficacy of anti-metabolite chemotherapeutics, such as gemcitabine and temozolomide, particularly in melanoma cell lines. GNE-783 is instrumental in research applications focused on overcoming drug resistance and improving treatment outcomes across various tumor types. -
Endogenous Metabolite
Prostaglandin D1 is an endogenous metabolite known for its role as a prostanoid. It exhibits both contractile and relaxant effects on isolated human pial arteries and acts as an inhibitor of ADP-induced platelet aggregation, with an IC50 value of 320 ng/ml. This compound is useful for studies in metabolic research and vascular biology. -
Endogenous Metabolite
Letimide hydrochloride is an endogenous metabolite with potent analgesic activity. In vitro studies have demonstrated its cytogenetic effects on human lymphocytes, while in vivo assessments in mouse bone marrow cells have shown no significant chromosomal aberrations or sister chromatid exchanges. Additionally, teratogenic studies in mice indicate that Letimide hydrochloride does not induce congenital malformations, supporting its safety profile for research applications in pain management and genetic stability.
