Catalog No.
Product Name
Application
Product Information
Citations
-
Endogenous Metabolite
Oleic Acid-2,6-diisopropylanilide is a potent inhibitor of acylCoA:cholesterol acyltransferase (ACAT), a key enzyme involved in the synthesis of cholesteryl esters related to dietary cholesterol absorption, with an IC50 of 7 nM. This compound has demonstrated biological activity by lowering low-density lipoproteins and increasing high-density lipoprotein levels in animal models subjected to high-fat, high-cholesterol diets. It serves as a valuable tool in research applications focused on lipid metabolism and cardiovascular disease. -
Endogenous Metabolite
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside that functions as an endogenous metabolite in various organisms, including humans, E. coli, and mice. It serves as an important intermediate in the biosynthesis of uridine monophosphate (UMP), making it crucial for nucleotide synthesis. This compound is commonly utilized in research to investigate the enzymatic mechanism of orotidine 5′-monophosphate decarboxylase, providing insights into metabolic pathways and cellular function. -
Endogenous Metabolite
Diphenamid is a potent herbicide that primarily targets the enzyme acetyl-CoA carboxylase, inhibiting key metabolic pathways in plants. Its use as a model compound for studying organic pollutants offers insights into wastewater treatment processes, particularly under varying anionic conditions. The degradation pattern of diphenamid is influenced by diverse inorganic ions, including chromium (VI) and nitrogen oxides, while prolonged exposure significantly alters its toxicity profile. Toxicity assessments on selected algal species indicate increased toxicity following extended treatment periods, making diphenamid relevant for environmental toxicity studies and pollutant degradation research. -
Endogenous Metabolite
6,7-Dimethyl-5,6,7,8-tetrahydropterin hydrochloride acts as a synthetic analogue of tetrahydro-L-biopterin, functioning as a crucial cofactor for various nitric oxide synthase isoforms, as well as phenylalanine, tyrosine, and tryptophan hydroxylases. This reagent plays an essential role in metabolic pathways involving neurotransmitter synthesis and is valuable for research into nitric oxide signaling, as well as disorders related to the metabolism of monoamines. Its use facilitates investigations into various physiological and pathological processes linked to these enzymes. -
Endogenous Metabolite
1,2-Dipropionyl-sn-glycero-3-phosphocholine targets the phospholipid characteristics important in membrane biology. This compound serves as an endogenous metabolite and is instrumental in studying the interactions between water molecules and the phosphocholine headgroup in aqueous environments. Its unique structure allows for detailed investigation into membrane dynamics and lipid bilayer properties. -
Endogenous Metabolite
1-(Palmitoyloxy)-3-(stearoyloxy)propan-2-yl oleate is a triacylglycerol comprising palmitic acid at the sn-1 position, oleic acid at the sn-2 position, and stearic acid at the sn-3 position. This compound serves as an important endogenous metabolite and is predominantly found in cocoa butter. Its study can provide insights into lipid metabolism and storage, as well as the physiological roles of triacylglycerols in various biological processes. -
Endogenous Metabolite
Scio-323 is an orally active inhibitor of the p38 mitogen-activated protein kinase (MAPK), primarily targeting chronic inflammatory responses linked to polyethylene particles. This compound has demonstrated the ability to reduce inflammation; however, it shows minimal impact on bone formation during such responses. Notably, Scio-323 treatment does not enhance bone growth in the presence of polyethylene particles, and osteoblast-like activity remains suppressed. This positions Scio-323 as a significant candidate for research into chronic inflammatory conditions affecting bone metabolism. -
Endogenous Metabolite
Metoxuron is a phenylurea herbicide that acts primarily by inhibiting photosynthesis in target plants. It effectively controls a range of annual grasses and broadleaf weeds, making it suitable for use in crops such as wheat, barley, and carrots. This compound serves as a valuable tool in agricultural research focused on weed management and herbicide efficacy studies. -
Endogenous Metabolite
D-Fructose-6-phosphate is an endogenous metabolite that plays a vital role in cellular metabolism through its involvement in the glycolysis and pentose phosphate pathways. This compound influences cell growth and autophagy and can be hydrolyzed by Fructose-1,6-bisphosphatase. Additionally, it can be isomerized to D-glucose-6-phosphate by phosphoglucose isomerase. D-Fructose-6-phosphate serves as a useful reagent for research on metabolic disorders, including studies related to Lewy body dementia. -
Fungal Metabolite
6-Hydroxyramulosin is a fungal metabolite that exhibits significant anticancer activity. It demonstrates cytotoxic effects against human lung cancer A549 and bladder cancer T24 cell lines, with IC50 values of 14.2 µg/mL and 15.3 µg/mL, respectively. This compound may serve as a valuable tool in cancer research, potentially aiding the development of novel therapeutic strategies. -
Endogenous Metabolite
Verdantiol is an endogenous metabolite categorized as a flavanol. It exhibits potential biological activity through its antioxidant properties, contributing to cellular defense mechanisms. This compound is primarily utilized in research applications focusing on metabolic pathways, oxidative stress studies, and evaluating the role of flavanols in human health. -
Endogenous Metabolite
DL-Stearoylcarnitine is the racemic form of Stearoylcarnitine, an endogenous metabolite involved in fatty acid metabolism. It plays a critical role in the transport of long-chain fatty acids into mitochondria for beta-oxidation. This compound is useful in research focused on metabolic disorders, energy metabolism, and mitochondrial dysfunction. Its biological activity can provide insights into lipid metabolism and potential therapeutic targets for related diseases. -
Endogenous Metabolite
18:0,22:6 PS sodium is a phospholipid that plays a critical role in the composition of synaptic vesicles and cholesterol metabolism. This endogenous metabolite is important for studying lipid interactions and their effects on synaptic function. Research applications include investigating neurochemical signaling processes and lipid metabolism in various biological systems. -
Endogenous Metabolite
α-Hydroxytriazolam is a significant endogenous metabolite of ranitidine, primarily acting as a proof-of-concept compound in pharmacokinetic studies. It demonstrates biological activity by influencing drug metabolism and clearance pathways. This compound is particularly relevant in research applications involving drug interactions and the evaluation of metabolic profiles in pharmacological studies. -
Endogenous Metabolite
1,2-Dioleoyl-3-docosohexaenoyl-rac-glycerol is a triacylglycerol comprised of oleic acid at the sn-1 and sn-2 positions, and docosahexaenoic acid at the sn-3 position. This endogenous metabolite is known to be present in human breast milk, highlighting its potential relevance in nutritional and developmental research. It serves as a valuable tool for studying lipid metabolism and elucidating the role of specific fatty acids in cellular processes. -
Endogenous Metabolite
9-OxoODE is an endogenous metabolite formed through the oxidation of the allylic hydroxyl group in either 9(S)- or 9(R)-HODE. This compound is present in rabbit reticulocyte plasma and mitochondrial membranes, accounting for approximately 2% of the total linoleate residues in these membranes. 9-OxoODE is predominantly esterified to membrane lipids, making it relevant for studies investigating lipid metabolism, oxidative stress, and cell membrane dynamics in various biological contexts. -
Endogenous Metabolite
Denagliptin is a small molecule inhibitor of dipeptidyl peptidase IV (DPP-4), primarily targeting endogenous metabolites involved in glucose metabolism. This compound demonstrates significant activity in the research of type 2 diabetes and offers insights into endocrine and metabolic disorders. While stable in the solid state, Denagliptin is known to degrade in solution and in various excipient mixtures, with degradation primarily occurring through cyclization reactions. Understanding its degradation pathways is crucial for advancing formulation development and regulatory compliance. -
Endogenous Metabolite
Platelet aggregation-IN-2 is an endogenous metabolite that functions as an effective anti-platelet aggregation agent. It demonstrates significant anticoagulant properties by inhibiting platelet aggregation, thereby reducing the risk of thrombosis. This compound holds potential applications in the prevention and management of cardiovascular diseases through its capacity to modulate platelet functions. -
Endogenous Metabolite
12(R)-HEPE is a monohydroxy fatty acid derived from eicosapentaenoic acid (EPA) and produced by the eggs of the sea urchin, Strongylocentrotus purpuratus. While the specific biological activities of 12(R)-HEPE remain underexplored, it is hypothesized to exhibit physiological effects akin to those of 12(R)-HETE. This compound serves as a valuable endogenous metabolite for research applications in lipid signaling and inflammatory responses. -
Endogenous Metabolite
L-Primapterin (7-Biopterin) is an endogenous metabolite that serves as a significant biomarker for hyperphenylalaninemia variant primapterinuria. This compound is primarily involved in the metabolism of phenylalanine and is excreted in the urine. Its detection and quantification are essential for research on phenylketonuria and related metabolic disorders, aiding in the understanding of amino acid metabolism and its clinical implications. -
Endogenous Metabolite
Anirolac (RS37326) is a nonsteroidal anti-inflammatory agent that targets endogenous pathways to provide analgesic effects. Demonstrating significant efficacy, Anirolac effectively alleviates moderate to severe postpartum uterine pain, with analgesia scores markedly superior to placebo, particularly at a dose of 100 mg within the first six hours. This compound is valuable for research applications aimed at understanding pain management and inflammation in obstetric contexts. -
Endogenous Metabolite
L-Pyroglutamic acid sodium primarily targets glutathione metabolism and acts as an endogenous metabolite. As the biologically active levo-isomer of pyroglutamic acid, it is involved in key metabolic processes within the body. This compound has been identified as a potential biomarker for systemic lupus erythematosus (SLE), making it a valuable tool in related research applications. -
Endogenous Metabolite
2-Iodoestradiol is a potent ligand for human sex hormone binding globulin (SHBG) with a high binding affinity, demonstrating competition with dihydrotestosterone at the same site on SHBG. Its binding affinity constant at physiological pH and 37 degrees Celsius is 2.4 x 10^9 M^-1, surpassing that of SHBG itself. Additionally, 2-Iodoestradiol can bind to serum albumin, although with reduced affinity. The radioisotope 125I-derivative of this compound is commonly employed in studies investigating the binding dynamics of human SHBG, making it a valuable tool for biological research applications. -
Endogenous Metabolite
Deacetyldiltiazem is an endogenous metabolite primarily acting as a coronary vasodilator. It is found in the plasma of individuals treated with Diltiazem and is metabolized via deacetylation, primarily catalyzed by the rat Ces2a enzyme. In vitro studies reveal that Deacetyldiltiazem exhibits efficient deacetylase activity, with Km values comparable to those observed in rat liver microsomes. Research on Deacetyldiltiazem contributes to the understanding of metabolic kinetic variations of compounds across different species. -
Endogenous Metabolite
IDX375 is a selective non-nucleoside inhibitor targeting the Hepatitis C Virus (HCV) NS5B polymerase. This compound exhibits potent inhibitory activity primarily against HCV genotypes 1a and 1b. The binding interactions and structural conformation of IDX375 have been validated through X-ray co-crystallization studies, providing insight into its mechanism of action. This reagent is useful for research applications focusing on HCV replication and therapeutic development. -
Endogenous Metabolite
Dihydro FF-MAS is a steroid triterpenoid that serves as an important intermediate in the cholesterol synthesis pathway. This compound has been shown to induce the resumption of meiosis in cultured mouse oocytes in vitro, making it a valuable tool for studying reproductive processes. Additionally, Dihydro FF-MAS can be utilized in research focused on lipid metabolism, offering insights into cellular and physiological mechanisms related to these biological systems. -
Fungal Metabolite
Acremine F is a fungal metabolite derived from the genus Acremonium, known for its antimicrobial properties. This compound exhibits significant activity against various fungal strains, making it a valuable tool for antifungal research and development. Its unique bioactivity profile supports studies in mycology and the exploration of potential therapeutic applications in treating fungal infections. -
Endogenous Metabolite
Conglobatin C1 is an endogenous bacterial metabolite that exhibits notable anticancer activity. It demonstrates cytotoxic effects against NS-1 mouse myeloma cells, with an IC50 of 1.05 μg/mL. This compound is valuable for research applications aimed at understanding cancer cell biology and exploring potential therapeutic strategies in oncology. -
Endogenous Metabolite
Guanosine triphosphate tritris (GTP tritris) is an essential endogenous metabolite involved in myogenic cell differentiation and modulation of miRNA-myogenic regulator factors. It facilitates the export of exosomes rich in guanosine and is a key activated precursor for RNA synthesis. GTP tritris is crucial for mitochondrial function, aiding in protein import into the matrix, initiating peptide synthesis, and driving polypeptide chain elongation. Furthermore, it serves as a phosphate and pyrophosphate carrier, activating signal transducing G proteins that influence cellular processes such as proliferation and apoptosis, while participating in vesicle docking and fusion through interactions with small GTPases. -
Endogenous Metabolite
Stercobilinogen is an endogenous metabolite derived from the bacterial metabolism of bilirubin. It serves as a significant biomarker in the study of gut microbiota and its influence on bilirubin metabolism. This compound is instrumental in metabolic research and contributes to the understanding of gastrointestinal health and liver function. -
Endogenous Metabolite
1,2-Dinervonoyl-sn-glycero-3-phosphocholine is an endogenous metabolite characterized by its two 24-carbon fatty acid chains, each containing a cis double bond at the 15th carbon. This phospholipid is believed to play a significant role in neuronal differentiation signaling and modulates various cellular processes in the nervous system. It serves as a valuable reagent for research aimed at elucidating the mechanisms of neurodevelopment and synaptic function. -
Endogenous Metabolite
1,6-Dimethylnaphthalene is an organic compound primarily recognized for its role as an endogenous metabolite. This compound exhibits flavoring and synergistic properties, making it valuable in various chemical synthesis applications. Additionally, 1,6-Dimethylnaphthalene serves as a catalyst in select reactions, contributing to compound development and environmental science research. Its unique characteristics make it suitable for the production of high-performance materials. -
Endogenous Metabolite
3-(Oleoyloxy)propane-1,2-diyl distearate targets endogenous metabolites and is classified as a triacylglycerol. This compound features stearic acid moieties at the sn-1 and sn-2 positions, with an oleic acid residue at the sn-3 position. It is naturally occurring in cocoa butter and various vegetable oils, making it relevant for studies on lipid metabolism and dietary fats. -
Endogenous Metabolite
ATP magnesium is an essential endogenous metabolite involved in energy storage and metabolism. It provides the necessary metabolic energy for various cellular processes and acts as a coenzyme in biochemical reactions. Additionally, ATP magnesium plays a critical role as a signaling molecule in immune responses and inflammatory processes, making it valuable for research into cellular signaling and metabolic pathways. -
Endogenous Metabolite
Pirbuterol dihydrochloride is a beta-2 adrenergic agonist that acts primarily as a bronchodilator. It exhibits comparable duration of action to albuterol when administered via inhalation, making it a useful agent for respiratory conditions. With similar beta-2 selectivity to albuterol in human studies, Pirbuterol dihydrochloride is valuable in research focused on airway responsiveness and therapeutic interventions for asthma or chronic obstructive pulmonary disease (COPD). -
Endogenous Metabolite
Ribulose 1,5-bisphosphate (RuBP) is a crucial photosynthetic intermediate that serves as a substrate for carbon fixation. It plays a pivotal role in catalyzing the carboxylation reaction and is essential for the regeneration phase of the Calvin cycle. RuBP binds tightly to inactive RuBP carboxylase, influencing photosynthetic efficiency and control dynamics. This compound is widely utilized in research focused on photosynthesis mechanisms and enzyme dynamics related to carbon fixation processes. -
Endogenous Metabolite
Docosapentaenoylcarnitine (C22:5n3) is an endogenous metabolite that plays a role in metabolic processes. This compound is involved in the regulation of fatty acid metabolism and has been implicated in various physiological pathways. Its unique structure allows it to participate in research applications related to lipid metabolism and energy homeostasis. -
Endogenous Metabolite
CHET3 is an endogenous metabolite that acts as a selective activator of TASK-3-containing K2P channels. It demonstrates significant analgesic activity, effectively modulating the membrane excitability of specific small sensory neurons. Research applications include studying acute and chronic pain models in mice, where CHET3's effects on thermal hypersensitivity and mechanical hyperalgesia can be thoroughly examined. The analgesic effects of CHET3 are sensitive to pharmacological inhibition and genetic knockout of TASK-3, highlighting its precise mechanism of action. -
Endogenous MetaboliteModulator
10(S),17(S)-DiHDHA is a dihydroxy fatty acid derived from docosahexaenoic acid (DHA) that serves as a modulator of endogenous metabolites. This compound demonstrates significant neuroprotective and anti-inflammatory properties, making it valuable for research in neurobiology and inflammation. It is commonly used in studies focusing on neuronal preservation and the regulation of inflammatory responses. -
Endogenous Metabolite
Pyrocatechol sulfate is an endogenous phenolic metabolite linked to dietary intake, particularly from foods such as berries, and may reflect gut microbiota status. It is a promising urinary biomarker for assessing kidney function, dialytic clearance, whole grain consumption, and regular coffee intake. Furthermore, Pyrocatechol sulfate contributes to the modulation of various biological activities, including neuroprotection and the regulation of cardiomyocyte rhythmicity, making it valuable for studies in nutrition, metabolism, and cardiovascular health. -
Endogenous Metabolite
Lophophine hydrochloride is an endogenous metabolite derived from the plant Lophophora diffusa, serving as an important intermediate in the synthesis of anhalonine and lophophorine. This compound exhibits notable biological activity, with anhalonine inducing mild sedative effects in amphibian models, while lophophorine is associated with significant neuroactive responses, including prolonged convulsions, increased reflex excitability, muscle rigidity, and paralysis in both rabbit and frog models. Lophophine hydrochloride is relevant for research in neuropharmacology and the study of natural product-derived compounds. -
Endogenous Metabolite
Diheptanoyl Thio-PC is a substrate designed for the enzymatic activity of phospholipase A2s (PLA2s), excluding cytosolic PLA2 and PAF-acetyl hydrolase. This compound undergoes hydrolysis at the sn-2 position, releasing a free thiol group on lysophospholipid. The resulting free thiol can be quantitatively measured using chromogenic assays, such as DTNB (Ellman’s reagent) and DTP, making it valuable for studies involving phospholipase activity and lipid metabolism. -
Endogenous Metabolite
Trans-Jasmone is an endogenous metabolite known for its aroma-inducing properties. This compound exhibits potential biological activity and is primarily utilized in the flavoring and fragrance industries to enhance the sensory profile of products. Its role as a flavoring agent makes it valuable for research applications related to aroma chemistry and sensory analysis. -
Endogenous metabolite
Cyclobenzaprine b-D-glucuronide is an endogenous metabolite of Cyclobenzaprine, primarily involved in the drug's metabolic pathways. This compound may facilitate research into the pharmacokinetics of Cyclobenzaprine and its therapeutic applications. Additionally, it holds potential for investigating treatment strategies related to coronavirus infections, thereby contributing to the broader understanding of antiviral therapeutic mechanisms. -
Endogenous Metabolite
C22 Phytoceramide (t18:0/22:0) is an endogenous sphingolipid that plays a vital role in cellular signaling and membrane structure. Isolated from Moro blood orange (Citrus sinensis) peels and present in primary human astrocytes, it is crucial for studying lipid metabolism and neurobiology. This compound is employed in research applications related to skin health, cellular differentiation, and neurodegenerative diseases. -
Endogenous Metabolite
A-395N is a structural analog of A-395, designed as a control probe for research involving the polycomb protein EED. This protein is critical to the Polycomb repressive complex 2 (PRC2), which mediates transcriptional repression through histone H3K27 methylation. A-395N exhibits no pharmacological activity in biochemical or cellular assays, confirming its effectiveness as a control compound in studies exploring EED function and PRC2-related pathways. -
Endogenous Metabolite
(+/-) 13-HODE cholesteryl ester is an endogenous metabolite derived from atherosclerotic lesions, produced through the Cu2+-catalyzed oxidation of low-density lipoprotein (LDL). It is synthesized by the action of lipoxygenase enzymes, particularly 15-lipoxygenase from rabbit reticulocytes and human monocytes, acting on cholesteryl linoleate, a key component of LDL. This compound is essential for studying lipid metabolism and the pathophysiological mechanisms involved in atherosclerosis and related cardiovascular conditions. -
Endogenous Metabolite
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is an endogenous metabolite derived from the bacterium Streptomyces albus. This compound exhibits significant biological activity, facilitating studies in microbiology and metabolic pathways. Its use in research provides insights into natural product biosynthesis and potential applications in antibiotic development. -
Endogenous Metabolite
2-Methyldecanenitrile is an endogenous metabolite known for its distinctive fragrance properties. This compound possesses a rich peach aroma complemented by frankincense undertones, making it suitable for use in perfume formulations. Its remarkable stability across a wide pH range allows it to maintain a consistent fruity effect even at low concentrations, enhancing scent profiles in various applications. -
Endogenous Metabolite
Prostaglandin F2α-1-glyceryl ester serves as an endogenous metabolite targeting 15-hydroxyprostaglandin dehydrogenase (15-HPGDH). This compound plays a role in the regulation of prostaglandin signaling pathways and is essential for studying lipid mediators in various physiological processes. Its biological activity can be leveraged in research applications focused on inflammation, reproductive biology, and vascular function.
