GSK-1562590 is a high-affinity antagonist of the uropeptide-II receptor, demonstrating notable selectivity. This compound exhibits significant antagonistic activity across various biological assays and maintains prolonged receptor binding. GSK-1562590 effectively inhibits human urinary peptide-II-induced aortic contraction in rat models, with effects persisting for a minimum of 24 hours. Its properties make it a valuable tool for investigating the role of uropeptide-II in cardiovascular physiology and related metabolic research.
GSK-1562590 is a high-affinity antagonist of the uropeptide-II receptor, demonstrating notable selectivity. This compound exhibits significant antagonistic activity across various biological assays and maintains prolonged receptor binding. GSK-1562590 effectively inhibits human urinary peptide-II-induced aortic contraction in rat models, with effects persisting for a minimum of 24 hours. Its properties make it a valuable tool for investigating the role of uropeptide-II in cardiovascular physiology and related metabolic research.
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