YM-355179 fumarate is a selective antagonist of the C-C chemokine receptor type 3 (CCR3), targeting eosinophil-related allergic inflammatory diseases. This compound effectively inhibits the binding of CCL11 and CCL5 to CCR3-expressing cells, exhibiting IC50 values of 7.6 nM and 24 nM, respectively. Functional assays demonstrate that YM-355179 fumarate inhibits CCL11-induced intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation, with IC50 values of 8.0 nM, 24 nM, and 29 nM, respectively. This makes it a valuable tool for researchers studying allergic inflammation and related conditions.
YM-355179 fumarate is a selective antagonist of the C-C chemokine receptor type 3 (CCR3), targeting eosinophil-related allergic inflammatory diseases. This compound effectively inhibits the binding of CCL11 and CCL5 to CCR3-expressing cells, exhibiting IC50 values of 7.6 nM and 24 nM, respectively. Functional assays demonstrate that YM-355179 fumarate inhibits CCL11-induced intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation, with IC50 values of 8.0 nM, 24 nM, and 29 nM, respectively. This makes it a valuable tool for researchers studying allergic inflammation and related conditions.
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