Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Chlorambucyl-proline is an amino acid derivative exhibiting inhibitory activity against bovine pulmonary vasoconstrictor enzyme. This compound functions as an irreversible inhibitor by forming ester bonds with the enzyme's aspartic or glutamic acid residues, leading to permanent enzyme inactivation. The rate of inactivation by chlorambucyl-proline is influenced by pH, with increased activity observed in the 5-8 range, making it a valuable tool for studying enzymatic regulation and function in physiological pH environments. -
Endogenous Metabolite
LY-79771 hydrochloride is a phenethanolamine compound that serves as an endogenous metabolite with antiobesity properties. It is primarily involved in inhibiting fat regain following energy deprivation, thereby aiding in weight management. This reagent is suitable for research applications focused on metabolic health and obesity-related studies. -
Endogenous Metabolite
Flurbiprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) targeting inflammatory pathways through the inhibition of carbonic anhydrase. It exhibits significant anti-inflammatory and analgesic properties, making it useful in the treatment of periodontal disease by reducing bone resorption. Additionally, Flurbiprofen sodium can be formulated into biodegradable microspheres for effective compound delivery, particularly within periodontal pockets, with the release kinetics influenced by the concentration of the polymer and polyvinyl alcohol used in its preparation. This compound is valuable for research into periodontal therapies and inflammation-related studies. -
Endogenous Metabolite
M-0002 hydrochloride is an antagonist of the vasopressin V2 receptor, acting as a key regulator of water balance and blood pressure. This compound is primarily investigated for its potential to inhibit ascites formation, making it relevant in research related to fluid retention disorders. Its favorable biological properties support further exploration in clinical applications. -
Endogenous Metabolite
Sermetacin (SH-G 318AB) is an endogenous metabolite with notable anti-inflammatory properties. This compound demonstrates strong biocompatibility, particularly in the RAW 264.7 mouse macrophage cell line, making it suitable for various biological applications. Sermetacin exhibits an anti-inflammatory response comparable to indomethacin, indicating its potential utility in research focused on inflammation pathways and therapeutic delivery mechanisms. -
Endogenous Metabolite
δ-CEHC is a metabolite of δ-tocopherol that acts primarily as an endogenous antioxidant. It demonstrates significant antioxidant activity, which may play a role in protecting cells from oxidative stress. δ-CEHC is utilized in research focused on investigating cellular responses to oxidative damage and exploring its potential therapeutic effects in various oxidative stress-related diseases. -
Endogenous Metabolite
Cyclo(Pro-Hyp) is a collagen-derived cyclic dipeptide that serves as an endogenous metabolite. Known for its role in promoting the proliferation of skin fibroblasts, Cyclo(Pro-Hyp) is crucial in tissue reconstruction processes. Its biological activity makes it a valuable reagent for research applications focusing on collagen metabolism and cellular regeneration in dermatological studies. -
Endogenous Metabolite
Cis-Vitamin K1 is an endogenous metabolite of Vitamin K that plays a critical role in the regulation of blood coagulation through its action as a cofactor for gamma-carboxylase. It promotes the post-translational modification of various proteins involved in hemostasis. This compound is utilized in research related to vitamin K biochemistry, coagulation studies, and the exploration of related metabolic pathways. Additionally, cis-Vitamin K1 may be investigated for its potential interactions in various physiological processes and disease states. -
Fungal Metabolite
Aspercolorin is a cyclic peptide fungal metabolite that exhibits significant antimicrobial properties. It has been studied for its potential use in inhibiting fungal growth, making it a valuable compound in antifungal research. Its unique structure and biological activity lend it to applications in investigating fungal metabolism and pathogenicity. -
Endogenous Metabolite
Pfn1-IN-2 is a selective inhibitor of Profilin1 (Pfn1), designed to disrupt the interaction between Pfn1 and actin filaments. This compound effectively decreases the levels of filamentous (F) actin within cells, leading to diminished migration and proliferation of endothelial cells. Pfn1-IN-2 demonstrates significant inhibition of endothelial cell angiogenic capabilities in both in vitro and in vivo research settings, making it a valuable tool for studies in angiogenesis and cellular dynamics. -
Fungal Metabolite
Carbolactone is a biologically active fungal metabolite known for its diverse biological activities. This compound exhibits antimicrobial properties, making it a valuable tool for research in mycology and natural product studies. Carbolactone's interaction with fungal systems can aid in the exploration of potential new antifungal agents and contribute to the understanding of fungal metabolism. -
Endogenous Metabolite
N-Succinyl-L-glutamate 5-semialdehyde is an endogenous metabolite involved in the glutamate metabolic pathway. It plays a significant role in the biosynthesis and metabolism of amino acids, particularly in the regulation of neurotransmitter levels. This compound is useful for research applications focused on metabolic processes, neurotransmission, and amino acid regulation. -
Endogenous Metabolite
VEC6 (NSC 11435) is an inhibitor of the VEZF1-DNA interaction, demonstrating significant activity in modulating vascular responses during ischemic retinopathy. It effectively reduces pathological angiogenesis while promoting lymphangiogenesis by influencing the expression of distinct gene sets in endothelial cells. VEC6 inhibits VEZF1-mediated transcriptional activity, thereby impacting endothelial cell proliferation and sprouting. This compound serves as a valuable tool for studying the molecular mechanisms of angiogenesis and lymphangiogenesis in various research applications. -
Endogenous Metabolite
MyomiRs-IN-1 is a specific inhibitor targeting endogenous metabolites involved in muscle cell differentiation. It effectively downregulates myoD protein translation in C2C12 cells without altering myoD mRNA levels, thereby affecting the expression of muscle differentiation markers. By modulating the regulatory pathway between miR-221/222 and myoD, MyomiRs-IN-1 is a valuable tool for researchers investigating muscle development and associated disorders. -
Endogenous Metabolite
A 62176 hydrochloride is a potent inhibitor of DNA topoisomerase II, demonstrating significant activity in disrupting purine synthesis in cancer cells. By interacting with G-quadruplex structures, A 62176 hydrochloride reduces c-MYC mRNA expression and displaces nucleosomes from the non-template strand of rDNA. This mechanism leads to DNA damage that necessitates repair via BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways, highlighting its potential applications in cancer research and therapeutic development. -
Endogenous Metabolite
L-Lysine orotate is a salt composed of L-lysine and orotic acid, functioning as an endogenous metabolite. This compound has been shown to potentiate the toxicity of extracts from the mushroom Amanita phalloides, making it relevant for studies investigating mycotoxin effects and metabolic pathways related to amino acids. Its unique interaction profile can be advantageous in research focused on toxicology and pharmacology. -
Endogenous Metabolite
(5R)-Dinoprost is an endogenous metabolite derived from the cyclooxygenase metabolism of arachidonic acid. As Prostaglandin F2β, it is known to induce a dose-dependent release of hexose-containing mucin. This compound is primarily utilized in research involving gastrointestinal physiology and reproductive biology, as well as studies exploring its roles in inflammation and smooth muscle contraction. -
Endogenous Metabolite
1a,1b-Dihomo prostaglandin F2α is a derivative of Prostaglandin F2α, acting as an endogenous metabolite. This compound plays a significant role in various biological processes, including inflammation and reproductive physiology. Its application in research is pivotal for studying prostaglandin pathways and their effects on cellular signaling and physiological functions. -
Endogenous Metabolite
1-(1Z-Octadecenyl)-2-docosahexaenoyl-sn-glycero-3-phosphocholine, also known as C18(Plasm)-22:6-PC, is an endogenous metabolite belonging to the phospholipid class. This compound exhibits significant variation in content and distribution across different fish species, making it a valuable biomarker for assessing species differentiation in ecological and nutritional studies. Its identification in fish viscera through lipidomics highlights its potential applications in marine biology and fishery science. -
Endogenous Metabolite
IRAK4-IN-29 is a selective inhibitor of the interleukin-1 receptor-associated kinase 4 (IRAK4), demonstrating low nanomolar activity. This compound effectively disrupts TLR-mediated signaling pathways and exhibits significant inhibition of cytokine production in response to LPS and R848 stimulation. In vivo studies reveal that IRAK4-IN-29 can suppress LPS-induced TNFα, mirroring the phenotype observed in IRAK4 gene-deficient mice. Furthermore, IRAK4-IN-29 possesses favorable medicinal chemistry characteristics, including microsomal stability and solubility, indicating its potential for clinical applications in inflammatory diseases. -
Endogenous Metabolite
Lu AF58801 is a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptors, demonstrating potent oral bioavailability and effective brain penetration. This compound has been shown to enhance receptor activity and improve cognitive function in animal models, specifically in a novel object recognition task in mice subjected to subchronic exposure to fluchlorothiazol. Lu AF58801 serves as a valuable tool for investigating the role of α7 nicotinic receptors in cognitive processes and related disorders. -
Endogenous Metabolite
Aquacobalamin is a biologically active form of vitamin B12, primarily functioning as a cofactor in various enzymatic reactions. It enhances the oxidation of azo-dye Orange II in the presence of hydrogen persulfate, demonstrating its potential as a catalyst in oxidative reactions. Additionally, Aquacobalamin binds reversibly to hydrogen peroxide, forming a cobalt(III) hydroperoxo adduct with a dissociation constant of 0.25 mM, contributing to its diverse applications in biochemical research and oxidative stress studies. -
Endogenous Metabolite
Clinolamide is an N-cyclohexyl linoleamide that primarily targets endogenous metabolites. In studies assessing cholesterol metabolism in rats, a dietary dose of 0.3% over 21 days did not significantly alter serum, liver, or kidney cholesterol levels. However, it exhibited variable effects on cholesterol synthesis in liver slices depending on the specific substrates and concentrations used. This compound is relevant for research on lipid metabolism and cholesterol regulation. -
Endogenous Metabolite
Naftidrofuryl is an endogenous metabolite known for its capacity to enhance cellular oxidative capacity and exhibit antispasmodic activity. It is utilized primarily in the study of peripheral and cerebrovascular diseases, demonstrating efficacy in improving blood circulation. Research applications include investigating its potential therapeutic effects in conditions related to compromised vascular function. -
Fungal Metabolite
Setosusin is a fungal meroditerpenoid known for its unique spiro-fused 3(2H)-furanone structure. This compound exhibits significant biological activity, particularly as a potential antifungal agent. It serves as a valuable tool for research applications focused on fungal metabolism and the development of novel antifungal therapeutics. -
Endogenous Metabolite
H-Arg-Lys-OH is a dipeptide composed of L-arginine and L-lysine residues, serving as a significant endogenous metabolite. This compound exhibits key biological activities that may influence cellular signaling pathways and protein interactions. It is utilized in biochemical research to explore mechanisms involving peptide-mediated biological functions and to study the roles of specific amino acid sequences in various physiological processes. -
Endogenous Metabolite
T-2 Triol is an endogenous metabolite derived from the metabolism of T-2 toxin, characterized by reduced toxicity relative to its parent compound. This trichothecene mycotoxin is of interest in studies concerning its pharmacokinetics, particularly in broiler chickens, where it exhibits a half-life (t1/2λz) of 9.6 minutes, peak plasma concentration (Cmax) of 563 ng/ml, and a time to peak concentration (Tmax) of 2.5 minutes. T-2 Triol serves as a valuable reagent for investigating mycotoxin metabolite dynamics in agricultural and toxicological research. -
Endogenous Metabolite
1-Myristoyl-2-palmitoyl-3-butyryl-rac-glycerol is an endogenous metabolite classified as a triacylglycerol, consisting of myristic, palmitic, and butyric acid residues. It plays a significant role in lipid metabolism and is naturally present in human milk, contributing to the nutritional profile and health benefits associated with breastfeeding. This compound is valuable for research in metabolic disorders, lipoprotein function, and studies related to infant nutrition. -
Endogenous Metabolite
Phochinenin I is an endogenous metabolite sourced from the plant Pholidota chinensis. This natural compound exhibits notable biological activity, including potential antioxidant and anti-inflammatory properties. Researchers utilize Phochinenin I in studies related to metabolic processes and the exploration of plant-derived therapeutics. -
Endogenous Metabolite
6-Hydroxypyridin-2(1H)-one hydrochloride is an endogenous metabolite that plays a significant role in various biological processes. This compound is involved in regulating metal ion homeostasis and may influence cellular oxidative stress pathways. It is commonly used in research focused on neurochemistry, metalloprotein interactions, and the study of metabolic disorders. -
Endogenous Metabolite
MMV667492 is a potent inhibitor of the cytoskeletal protein Ezrin, effectively targeting its function in cellular processes. This compound demonstrates significant anti-invasion activity in osteosarcoma cells, hindering their metastatic potential. In addition to its in vitro efficacy, MMV667492 induces distinct morphological defects in zebrafish embryos, aligning with Ezrin inhibition mechanisms. Furthermore, it reduces lung metastasis in osteosarcoma models characterized by elevated Ezrin expression, making it a valuable tool for studying tumor biology and metastasis. -
Endogenous Metabolite
(S)-Mevalonic acid is an endogenous metabolite that serves as a crucial precursor in the mevalonate pathway, which is vital for cell growth and proliferation. It has been shown to effectively inhibit the decrease in viability induced by Simvastatin in C2C12 cells in vitro. This compound is valuable for research focused on conditions such as myopathy and heart failure, facilitating studies on metabolic disorders and potential therapeutic interventions. -
Endogenous Metabolite
PTC-510 Free Base is a selective inhibitor of hypoxia-induced VEGF expression in tumor cells. It effectively reduces endogenous VEGF production under hypoxic conditions, demonstrating significant activity in controlling tumor growth while minimizing associated toxicity. This compound offers a novel therapeutic approach to overcome the limitations of existing anti-VEGF therapies, making it a valuable tool for cancer research and therapeutic development. -
Endogenous Metabolite
Razobazam is a benzodiazepine derivative that primarily targets the central nervous system to enhance cognitive function. It has demonstrated significant effects on learning performance in socially deprived rat models, showing an 18% increase in avoidance scores post-training. Furthermore, Razobazam induces notable alterations in the optical density of specific brain regions, including a 22% reduction in the lateral habenula and a 25% increase in the ventral tegmental area, along with a 13% increase in the prefrontal cortex. This compound is valuable for research in neuropharmacology and cognitive enhancement. -
Endogenous Metabolite
Alterporriol B is an endogenous metabolite characterized by its red pigmentation, isolated from the fungus Alternaria porri, which is known to cause black spot disease in allium species. This compound is utilized in research to study fungal metabolites and their biological effects, making it a valuable reagent for investigations into plant-pathogen interactions and mycology. -
Endogenous Metabolite
R1498 is a multi-target kinase inhibitor primarily affecting Aurora kinases and VEGFR2, associated with tumorigenesis. This compound exhibits notable anti-angiogenic and anti-proliferative properties, demonstrating moderate in vitro growth inhibition across various tumor cell lines with IC50 values in the micromolar range. In vivo studies reveal that R1498 surpasses sorafenib in anti-tumor efficacy within gastric cancer and hepatocellular carcinoma xenograft models, achieving tumor growth inhibition rates exceeding 80% along with substantial tumor shrinkage in select models. Additionally, R1498 effectively inhibits Aurora A activity and reduces tumor vascularization, underscoring its potential as a therapeutic candidate in oncology research. -
Fungal Metabolite
Valinotricin is a bioactive fungal metabolite with notable antibacterial properties. It exhibits significant activity against a range of bacterial strains, making it a valuable tool for research in microbial pathogenesis and antibiotic discovery. Its unique mechanism of action may provide insights into novel therapeutic strategies against resistant bacterial infections. -
Endogenous Metabolite
H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders. -
Endogenous Metabolite
JTV-803 mesylate is a selective inhibitor of human factor Xa, functioning as an oral anticoagulant. It demonstrates competitive inhibition with a Ki value of 0.019 μM and an IC50 value of 0.081 μM, showcasing a remarkable specificity over comparable inhibitors. JTV-803 is primarily used in research focused on thrombosis prevention and the modulation of coagulation pathways, making it a valuable tool for studies in cardiovascular and hematological contexts. -
Endogenous Metabolite
Manninotrionate potassium is a hapten utilized for the development of immunogenic protein conjugates, notably with bovine serum albumin (BSA) or ovalbumin. This reagent has shown potential in eliciting antisera that exhibits weak precipitation reactions with various endogenous metabolites, including bovine lung galactan and polysaccharides such as guaran, gum arabic, and larch arabinogalactan. Its applications in research include studies of carbohydrate recognition and immune response characterization. -
Endogenous Metabolite
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine is a nucleoside analogue that specifically targets HBV reverse transcriptase, effectively inhibiting its activity. This compound demonstrates significant antiviral properties, particularly in controlling hepatitis B virus (HBV) replication in vitro. Its application in research provides a promising avenue for the development of therapies aimed at suppressing chronic hepatitis B infections. -
Endogenous Metabolite
Zofenoprilat arginine is an endogenous metabolite that functions as an antihypertensive agent, primarily through the enhancement of bradykinin effects on coronary flow. This compound is of particular interest in cardiovascular research, especially in studies involving the interplay of sulfhydryl-containing converting enzyme inhibitors and bradykinin-mediated vasodilation. Its role in influencing vascular response makes it a valuable tool for understanding hypertension and related cardiovascular conditions. -
Endogenous Metabolite
NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity. -
Endogenous Metabolite
N1-Acetylspermine is an endogenous metabolite that plays a significant role in cellular polyamine metabolism. This compound is primarily implicated in oncological research, particularly concerning leukemia, as it is involved in cellular proliferation and differentiation processes. Its measurement in biological samples, such as urine, can provide valuable insights into metabolic alterations associated with cancer progression and treatment response. -
Endogenous Metabolite
BuChE-IN-14 is a selective inhibitor of acetylcholinesterase (AChE), primarily targeting endogenous metabolite pathways. In vitro studies demonstrated a concentration-dependent inhibition of AChE activity in rat brain tissue, leading to increased extracellular acetylcholine (ACh) levels in the hippocampus and striatum. This compound shows potential for addressing memory impairments linked to cholinergic dysfunction, making it valuable for research into neurodegenerative diseases and cognitive enhancement. -
Fungal Metabolite
Trichodecenin I is a fungal metabolite that functions as a peptaibol, comprising a sequence of seven amino acid residues. This compound exhibits notable biological activity, particularly against various fungal strains, making it a valuable tool in antifungal research. Its unique structure and mechanism of action facilitate studies in natural product chemistry and the development of new antifungal agents. -
Endogenous Metabolite
Metanilic acid is an endogenous metabolite known for its potential anti-cancer properties. It has been investigated for use in treating various malignancies, including choriocarcinoma and pediatric acute lymphoblastic leukemia. This compound serves as a valuable tool for research in cancer biology and therapeutic development. -
Endogenous Metabolite
LY 190388 is a penicillamine-containing enkephalin peptide analog that acts as a μ-opioid receptor agonist. This compound demonstrates significant analgesic effects, as evidenced by its ability to inhibit the writhing response in mice following intracerebroventricular administration. Notably, the analgesic properties of LY 190388 are primarily attributed to its μ receptor activity, while co-administration with the δ receptor antagonist ICI 174864 produces an additive analgesic effect, supporting its potential applications in pain research. -
Endogenous metabolite
N,N-Dimethylamidino Urea is an endogenous metabolite that serves as an important intermediate in the electrochemical oxidation of Metformin. This compound can be utilized as a biomarker to investigate the metabolic pathways associated with Metformin in vivo. Its role in studying metabolic processes makes it a valuable reagent for research in diabetes and related metabolic disorders. -
Endogenous Metabolite
(E/Z)-PG-11047 is a polyamine analog that targets polyamine metabolism and exhibits potential for lung cancer inhibition. This compound has been shown to effectively inhibit the growth of both non-small cell and small cell lung cancer cells. Through significant downregulation of polyamine synthetase activity, (E/Z)-PG-11047 induces alterations in polyamine levels, making it a valuable tool for research in lung cancer biology and therapeutic development.
