MAGL-IN-3 is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 34.1 nM. This compound effectively reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release in Neuro2a cells at a concentration of 1 μM. Additionally, administration of MAGL-IN-3 at a dosage of 10 mg/kg significantly elevates levels of 2-arachidonoyl glycerol in mouse brain, making it a valuable tool for studying endocannabinoid signaling and neurobiological processes.
MAGL-IN-3 is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 34.1 nM. This compound effectively reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release in Neuro2a cells at a concentration of 1 μM. Additionally, administration of MAGL-IN-3 at a dosage of 10 mg/kg significantly elevates levels of 2-arachidonoyl glycerol in mouse brain, making it a valuable tool for studying endocannabinoid signaling and neurobiological processes.
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