aPKC-IN-2 is a selective inhibitor of atypical protein kinase C (aPKC), targeting its activity to modulate cellular signaling pathways. This compound effectively reduces vascular endothelial permeability in both in vitro and in vivo models, demonstrating significant actions against vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF). aPKC-IN-2 interferes with NFκB-mediated gene transcription, highlighting its role in regulating inflammatory responses. The EC50 value of aPKC-IN-2 is in the low nanomolar range, laying the groundwork for advancing small molecule aPKC inhibitors in therapeutic research.
aPKC-IN-2 is a selective inhibitor of atypical protein kinase C (aPKC), targeting its activity to modulate cellular signaling pathways. This compound effectively reduces vascular endothelial permeability in both in vitro and in vivo models, demonstrating significant actions against vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF). aPKC-IN-2 interferes with NFκB-mediated gene transcription, highlighting its role in regulating inflammatory responses. The EC50 value of aPKC-IN-2 is in the low nanomolar range, laying the groundwork for advancing small molecule aPKC inhibitors in therapeutic research.
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