Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies.
Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies.
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