Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane is a versatile click chemistry PEG reagent featuring three carboxylic acid groups and a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds with TCO-containing compounds through a rapid inverse-electron demand Diels-Alder cycloaddition, notable for its exceptional selectivity and lack of reliance on copper catalysts or elevated temperatures. Additionally, the terminal carboxylic acid can react with primary amine groups using coupling agents such as EDC or HATU to generate stable amide bonds, making it suitable for various biochemical assay applications.
Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane is a versatile click chemistry PEG reagent featuring three carboxylic acid groups and a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds with TCO-containing compounds through a rapid inverse-electron demand Diels-Alder cycloaddition, notable for its exceptional selectivity and lack of reliance on copper catalysts or elevated temperatures. Additionally, the terminal carboxylic acid can react with primary amine groups using coupling agents such as EDC or HATU to generate stable amide bonds, making it suitable for various biochemical assay applications.
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