Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). It features a tetrazine moiety that facilitates rapid and selective conjugation through an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives. This compound enhances the stability and efficacy of ADCs, making it valuable for targeted delivery of therapeutics in cancer research and other applications in bioconjugation.
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). It features a tetrazine moiety that facilitates rapid and selective conjugation through an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives. This compound enhances the stability and efficacy of ADCs, making it valuable for targeted delivery of therapeutics in cancer research and other applications in bioconjugation.
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