Fig. 1 · Structure
Documents & Downloads
Biotin-PEG4-methyltetrazine
PROTAC Linker
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecular constructs. This compound features a tetrazine moiety that facilitates click chemistry via an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO) derivatives. Its biological activity allows for the selective recruitment of E3 ligases, making it a valuable tool for researchers studying protein regulation and degradation pathways. This reagent is essential for the development of innovative therapies utilizing PROTAC technology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1835759-81-3 |
| Applications | PROTAC Linker |
| Formula | C27H39N7O6S |
| Molecular Weight | 589.71 |
| SMILES | O=C(NCCOCCOCCOCCOC1=CC=C(C2=NN=C(C)N=N2)C=C1)CCCC[C@H]3SC[C@@]([C@@]3([H])N4)([H])NC4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.