Catalog No.
Product Name
Application
Product Information
Citations
-
Kinesin Activator
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that activates kinesins, facilitating the targeted recruitment of proteins to cellular structures. This compound responds to light signals, enabling the dynamic interaction with kinetochores by either recruiting or releasing proteins, particularly CENP-E (kinesin-7). TNH is a valuable tool for studying protein dynamics in mitosis and investigating the mechanisms of cellular transport and division. -
Eg5 Inhibitor
Terpendole E is a specific inhibitor of the mitotic kinesin Eg5, targeting its motor and microtubule-stimulated ATPase activities in human cells. This compound effectively induces the formation of a monoastral spindle during the M phase of the cell cycle, making it a valuable tool for investigating mitotic processes. Terpendole E is suitable for research applications focused on cancer biology and drug discovery targeting cell division. -
CENP-M Inhibitor
Cenpemlin is a selective inhibitor of CENP-M, specifically disrupting the CENP-M/CENP-L interaction. This compound is valuable for studying centromere-kinetochore dynamics and assembly during cell division, providing insights into the mechanisms underlying chromosomal segregation. Research involving Cenpemlin can enhance the understanding of mitotic processes and potential therapeutic targets in cancer. -
Kinesin spindle protein
ALN-12115 is a small interfering RNA (siRNA) designed to specifically target kinesin spindle protein (KSP). It plays a key role in inhibiting mitotic spindle function, leading to cell cycle arrest and potential antitumor activity. ALN-12115 is part of the ALN-VSP lipid nanoparticle formulation, which also includes a siRNA targeting VEGF, making it suitable for research applications in cancer therapy and the study of tumor biology. -
Kinesin Inhibitor
MKLP2-IN-1 is a selective inhibitor of the kinesin MKLP2, demonstrating significant oral bioavailability. This compound effectively inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro, contributing to its potential as a therapeutic agent. In vivo studies reveal that MKLP2-IN-1 suppresses tumor growth in a mouse model of Calu-6 lung cancer, showcasing its relevance in cancer research and treatment strategies targeting kinesin-driven processes. -
KIF18A Inhibitor
KIF18A-IN-15 is a selective KIF18A inhibitor that demonstrates potent activity with IC50 values ranging from 0.01 to 0.1 μM. This compound effectively reduces the viability of OVCAR-3 cells, making it a valuable tool in cancer research. KIF18A-IN-15 can be utilized in studies related to various tumor models, including colon, breast, and lung cancers, facilitating the exploration of KIF18A's role in tumor growth and progression. -
KIF18A Inhibitor
KIF18A-IN-18 is a selective inhibitor of KIF18A, a motor protein involved in chromosome segregation during cell division. This compound has demonstrated the ability to disrupt KIF18A’s function, making it a valuable tool for studying chromosomal instability in tumors. Its application extends to research focused on understanding the mechanisms of tumorigenesis and potential therapeutic strategies in the context of cancer. -
HSET Inhibitor
CCT369834 is an ATP-competitive inhibitor of HSET, exhibiting an IC50 of 39 nM. This compound is a trans-cyclooctene-tagged probe that demonstrates specific co-localization with HSET on mitotic spindles. CCT369834 serves as a valuable tool for studying the role of HSET in cancer research and may contribute to understanding its function in mitotic processes. -
Kinesin Protein Ligand
KSP Ligand 1 is a selective ligand for kinesin spindle protein (KSP), which plays a critical role in cell division. This compound serves as a valuable tool in the development of proteolysis-targeting chimeras (PROTACs), specifically KSP-IN-1, for cancer research applications. Its ability to modulate KSP activity offers potential insights into therapeutic strategies for various malignancies. -
KIF18A Inhibitor
KIF18A-IN-16 is a potent inhibitor of KIF18A, a kinesin motor protein involved in mitotic spindle assembly and chromosome segregation. This compound has demonstrated significant biological activity in preclinical models and is valuable for research applications in oncology, particularly in the study of various cancer types, including colon, breast, and lung cancer. Its ability to disrupt KIF18A function makes it a promising candidate for investigating novel therapeutic strategies in cancer treatment. -
KSP Inhibitor
CK0106023 is a selective allosteric inhibitor of kinesin spindle protein (KSP) with a Ki value of 12 nM. This compound induces mitotic arrest and growth inhibition across various tumor cell lines, demonstrating significant antitumor activity. Additionally, CK0106023 has shown efficacy in preclinical models, specifically in tumor-bearing mice, making it a valuable reagent for cancer research and therapeutic development. -
Kinesin Inhibitor
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor targeting vertebrate Kinesin Spindle Protein (KSP). This compound demonstrates enhanced inhibitory activity against NCI60 tumor cell lines, attributed to modifications in its trityl and cysteine groups. It exhibits an EC50 of 28 μM for bipolar spindle formation, indicating superior potency compared to its parent compound and monastrol. This makes it a valuable tool for investigating KSP's role in mitosis and potential therapeutic strategies in cancer research. -
Kinesin Inhibitor
Monastroline (HR22C16) is a selective inhibitor of the mitotic kinesin Eg5, which plays a critical role in mitosis and cell division. This compound effectively disrupts mitotic processes, making it a valuable tool for studying cell cycle regulation and kinesin function in cancer research and related fields. Monastroline demonstrates strong cell permeability, facilitating its use in cellular assays to explore the therapeutic potential of kinesin inhibition. -
Kinesin-13 Inhibitor
DHTP is a selective allosteric inhibitor of the kinesin-13 family of microtubule depolymerases, targeting ATPase activity and microtubule depolymerization. It inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, without affecting other kinesin families. By modulating microtubule dynamics in cells, DHTP results in reduced microtubule activity, linking kinesin-13 overexpression to cancer progression and resistance to Paclitaxel. This compound is suitable for cancer research applications. -
SKP Inhibitor
KSP-IN-1 is a potent kinesin spindle protein (KSP) inhibitor, exhibiting an IC50 of 450 nM. This compound effectively disrupts mitotic spindle formation, thereby hindering cell division. KSP-IN-1 is valuable for researchers investigating cancer mechanisms and the role of mitotic regulation in oncology. -
Kinesin-5 Inhibitor
NSC-80141 is a selective inhibitor of kinesin-5, targeting the human kinesin-5 (HsEg5) with an IC50 of 9.4 μM, while exhibiting weaker inhibition against Plasmodium kinesin-5 (PvEg5) at an IC50 of 27.3 μM. This compound is valuable for research applications focused on differentiating human kinesin-5 from its Plasmodium counterpart, making it a useful tool for studying cellular transport mechanisms and potential therapeutic interventions in parasitic infections. -
PAK4 Inhibitor
CZh226 is a selective inhibitor of PAK4 with an IC50 of 0.0111 μM and a Ki of 0.009 μM. This compound effectively inhibits PAK4 activity, leading to decreased phosphorylation of its downstream signaling molecules. CZh226 has demonstrated the ability to inhibit the migration and invasion of tumor cells, making it a valuable reagent for research related to lung cancer and other PAK4-mediated pathways. -
Antitubulin Agent
AVE-8063, an aminocombretastatin, serves as a potent antitubulin agent. It demonstrates strong cytotoxic effects, making it a valuable compound for research into leukemic and breast cancer treatments. Its ability to disrupt microtubule dynamics can provide insights into cancer cell proliferation and survival mechanisms. -
Tubulin Inhibitor
ON 01500 is a potent tubulin inhibitor with a Kd of 21 nM, demonstrating significant microtubule-destabilizing effects in cellular environments. This compound is valuable for investigating mechanisms underlying cancer biology and the role of microtubule dynamics in cellular processes. Research applications include elucidating the effects of microtubule disruption on tumor growth and progression. -
Intermediate Reactant
Monomethyl auristatin E intermediate-1 is a key intermediate reactant used in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with notable anticancer activity. MMAE serves as the cytotoxic agent in antibody-drug conjugates (ADCs), making it valuable in targeted cancer therapies. This intermediate is essential for the development of innovative ADC formulations aimed at enhancing therapeutic efficacy in oncology research. -
Amino acid residues of Dolastatin 10
N-Boc-dolaproine, as a derivative of Dolastatin 10, targets the amino acid residues critical for the pentapeptide's function. It is known to inhibit tubulin polymerization, thereby disrupting mitosis and demonstrating significant anticancer activity. This compound is valuable for researchers investigating cellular dynamics and developing potential cancer therapies. -
Plant Microtubule Inhibitor
Oryzalin is a dinitroaniline herbicide that functions as a plant microtubule inhibitor. It binds to tubulin, disrupting microtubule polymerization in plant cells, which subsequently impairs chromosome migration. Oryzalin also serves as an effective reagent for inducing chromosome doubling, making it valuable for various research applications in plant biology and genetics. -
Tubulin Polymerization Inhibitor
ER-076349 is a potent inhibitor of tubulin polymerization that effectively induces G2-M cell cycle arrest and disrupts mitotic spindle formation. This compound demonstrates significant anti-cancer activity by inhibiting the growth of various human tumor xenografts. As an analog of Halichondrin B, ER-076349 serves as a valuable reagent for research focused on cancer biology and therapeutic development targeting microtubule dynamics. -
Active Metabolite of Taxol
7-epi-Taxol is an active metabolite of Taxol that primarily targets microtubules, promoting their stabilization and microtubule bundle formation while inhibiting depolymerization. This compound exhibits potent antitumor activity, making it a valuable tool for research in cancer biology and drug discovery. Its effects on cell replication highlight its potential applications in studying mitotic processes and cellular dynamics. -
Tubulin Inhibitor
Vindesine sulfate is a potent tubulin inhibitor with a Ki of 0.110 μM. It exhibits significant anti-proliferative activity in vitro and demonstrates antitumor effects in vivo, making it a valuable tool for cancer research. This compound is utilized in studies exploring microtubule dynamics and the mechanisms of action in various tumor models. -
Microtubule Regulators
Tetrahydrocortisol is a cortisol metabolite that targets microtubule regulators. It inhibits dexamethasone-induced formation of cross-linked actin networks, making it a valuable tool for studying cellular dynamics. This compound is applicable in research related to primary open-angle glaucoma, glucocorticoid-induced ocular hypertension, Lewis lung carcinoma, and EMT-6 mouse breast cancer. -
Anti-5T4 Antibody
Cys-McMMAF is the active payload derived from AlMcMMAF, a humanized A1 antibody specifically targeting the 5T4 antigen, conjugated to the microtubule-disrupting agent MMAF through a maleimidocaproyl linker. This compound demonstrates significant antitumor efficacy in mouse models, specifically H1975 and MDA-MB-361-DYT2, making it a valuable tool for cancer research and the development of targeted therapeutics. Cys-McMMAF is ideal for studies focused on antibody-drug conjugates and their potential in oncological therapies. -
Tubulin Assembly Inhibitor
Avanbulin is a potent tubulin assembly inhibitor that targets the Colchicine binding site on tubulin. It effectively inhibits tubulin polymerization at a temperature of 37 °C, exhibiting an IC50 value of 1.4 μM and an apparent Kd of 244 nM for tubulin binding. This compound is valuable for research applications in cancer biology and the study of cell division mechanisms. -
sGC Inhibitor
Methylene blue hydrate is a selective inhibitor of soluble guanylyl cyclase (sGC), as well as monoamine oxidase A (MAO-A) and nitric oxide synthase (NOS). This compound exhibits significant biological activities, including the modulation of the nitric oxide syntase/guanylate cyclase signaling pathway, which results in decreased prepulse inhibition. Methylene blue hydrate also acts as a REDOX cycling agent capable of crossing the blood-brain barrier, demonstrating neuroprotective effects such as inhibition of Tau aggregation, reduction of cerebral edema, and attenuation of neuroinflammation through the modulation of microglial activation. These properties make it valuable for research in neurodegenerative diseases and neuroinflammation studies. -
β-tubulin Polymerization Inhibitor
Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor that serves as a vascular disrupting agent. It demonstrates significant antitumor activity against both murine and human solid tumors, making it an important tool for cancer research. Valecobulin hydrochloride is utilized in studies focused on understanding tumor vascularization and therapeutic strategies aimed at disrupting the tumor microenvironment. -
Disinfection Byproduct
2-Bromoacetamide is a disinfection byproduct that primarily targets liver alcohol dehydrogenase, leading to its inactivation. This compound also disrupts microtubule and actin cytoskeletal functions, which can have significant effects on cellular processes. Additionally, 2-Bromoacetamide exhibits powerful developmental toxicant properties in animal models, making it relevant for studies in toxicology and developmental biology. -
Plant Microtubule Polymerization Inhibitor
Amiprofos methyl is a phosphoric amide herbicide that functions as a potent inhibitor of plant microtubule polymerization. This compound disrupts microtubule dynamics in plant cells, leading to significant impairments in cell division and growth. Its specific activity makes it a valuable tool for research into the mechanisms of herbicide action and the cellular processes regulated by microtubules in plant biology. -
TG Inhibitor
NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible inhibitor of transglutaminase (TG), a crucial enzyme in various biological processes. This compound effectively inhibits osteoblast differentiation and mineralization while also destabilizing microtubules. NC9 is valuable for research focused on osteoblast differentiation and the underlying mechanisms governing bone formation. -
Microtubule Stabilizer
TPI-287 is a microtubule stabilizer that effectively penetrates the blood-brain barrier. This compound demonstrates significant inhibitory effects on metastatic colonization of breast cancer in the brain. TPI-287 is useful in research aimed at understanding tumor progression and developing therapeutic strategies for brain metastases. -
Neurosteroid
Pregnenolone acetate is a neurosteroid that functions as an analog of pregnenolone, promoting neurite extension and altering growth cone morphology in primary cultures of cerebellar granule neurons. This compound enhances microtubule polymerization, making it a valuable tool for researching neurodevelopmental diseases. Its mechanism offers insights into neuronal growth and plasticity, supporting various applications in neuroscience research. -
Amino acid residues of Dolastatin 11
N-Boc-dolaproine dicyclohexylamine is an amino acid derivative of the peptide Dolastatin 10, targeting the amino acid residues of Dolastatin 11. This compound exhibits potent inhibition of tubulin polymerization, thereby disrupting mitosis and demonstrating significant anticancer properties. It serves as a critical tool for research in cancer biology and drug development, providing insights into the mechanisms of microtubule dynamics and cell division. -
Paclitaxel Derivative
Paclitaxel-2'-succinate NHS ester is a reactive paclitaxel derivative that features a succinic acid linker with a highly activated NHS ester group. This compound facilitates efficient conjugation with amino or hydroxyl groups, making it suitable for coupling with peptides, proteins, antibodies, enzymes, or polymers. Its applications extend to the development of innovative nanomedicines and the exploration of targeted strategies in cancer therapy. -
Intermediate Reactant
Monomethyl auristatin E intermediate-7 is a key intermediate in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with established anticancer properties. MMAE serves as a cytotoxic component in antibody-drug conjugates (ADCs), which are utilized in targeted cancer therapies. This reagent is essential for researchers engaged in the development and optimization of ADC formulations aimed at enhancing therapeutic efficacy in oncology. -
Microtubule-targeting Agent
Epothilone F is a 16-membered macrolide that targets microtubules, functioning as a potent anticancer agent. It demonstrates remarkable efficacy against paclitaxel-resistant cancer cells and effectively inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells. This compound is extensively utilized in research focused on cancer biology and therapeutics. -
Dolastatin 10 Synthesis Intermediate
(S)-Dolaphenine hydrochloride serves as a synthesis intermediate for Dolastatin 10, a potent antineoplastic agent. This compound acts by inhibiting tubulin polymerization, thereby disrupting microtubule dynamics crucial for cell division. Research applications include the investigation of cancer therapeutics and the exploration of novel chemotherapeutic strategies. -
Taxane Derivative
10-Deacetyltaxol, a taxane derivative, primarily targets tubulin polymerization in microtubule dynamics. It effectively promotes the assembly of tubulin and inhibits depolymerization induced by cold conditions or calcium ions in vitro. This compound displays significant cytotoxicity against human glial and neuroblastoma cell lines, making it valuable for research in cancer biology and therapeutics. -
Microtubule/Tubulin
MAP4343 is a 3-methylether derivative of pregnenolone that targets microtubules by binding to microtubule-associated protein 2 (MAP2). It stimulates tubulin polymerization, promotes neurite extension, and provides neuroprotective effects against neurotoxic agents. This compound has significant applications in neurobiology research and studies focused on neuronal development and protection. -
Microtubule/Tubulin Inhibitor
TN-16 is a potent microtubule polymerization inhibitor with an IC50 value ranging from 0.4 to 1.7 µM. It targets tubulin to disrupt microtubule dynamics, thereby affecting cellular processes such as mitosis and intracellular transport. TN-16 is useful in research applications exploring cancer biology and cellular function, making it an important tool for studying the role of microtubules in various diseases. -
Amino acid residues of Dolastatin 13
N-Boc-dolaproine-methyl is an amino acid derivative derived from Dolastatin 10, a pentapeptide known for its role in inhibiting tubulin polymerization. This compound demonstrates significant anticancer activity by disrupting mitosis and cellular proliferation. It is valuable for research applications focused on cancer biology and the development of novel therapeutics targeting cytoskeletal dynamics. -
Microtubule/Tubulin Inhibitor
Pironetin is an α/β unsaturated lactone derived from Streptomyces species that acts as a potent microtubule/tubulin inhibitor. By binding to α-tubulin, Pironetin effectively inhibits microtubule polymerization, leading to cell cycle arrest and exhibiting significant antitumor activity. This compound is valuable for research into cancer biology and the mechanisms of microtubule dynamics. -
Tubulin Destabilizer
RGN6024 is a reversible small molecule tubulin destabilizer that effectively inhibits microtubule polymerization by targeting the colchicine binding pocket of β-tubulin. With a binding affinity of Kd = 6.7 μM as measured by surface plasmon resonance, RGN6024 induces G2/M phase arrest in glioblastoma cells and demonstrates efficacy in βIII-tubulin overexpressing cell models. Additionally, RGN6024 inhibits tumor growth in glioblastoma xenograft mouse models, making it a valuable tool for research into glioblastoma pathophysiology and therapeutic strategies. -
Microtubule/Tubulin Inhibitor
Taccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies. -
Microtubule-targeting Agent
ST-401 is a microtubule-targeting agent (MTA) that acts as an assembly inhibitor. By moderately and reversibly disrupting microtubule assembly, ST-401 induces mitotic delay and promotes cell death during interphase. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research and studies focused on microtubule dynamics. -
Intermediate Reactant
Monomethyl auristatin E intermediate-15 is a crucial intermediate in the synthesis of Monomethyl auristatin E (MMAE). MMAE functions as a microtubule and tubulin inhibitor, exhibiting significant anticancer activity. This compound is predominantly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), thereby enhancing targeted cancer therapies. Its role in facilitating the production of MMAE makes it an important reagent for researchers focused on developing innovative cancer treatments. -
Microtubule Destabilizing Agent
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a microtubule destabilizing agent. This compound demonstrates significant anticancer activity and can be employed in cancer research to elucidate mechanisms of tumor cell proliferation and apoptosis. Its halogenated structure enhances its interaction with microtubules, making it a valuable tool for studying cytoskeletal dynamics and evaluating potential therapeutic strategies.
