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Catalog No.
Product Name
Application
Product Information
Product Citation
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VCAM-1 antagonist
CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 binding to ??4-integrins- Mustafa Ahmadzai, .et al. , Front Immunol, 2015, 6: 525 PMID: 26539194
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α4β1/α4β7 integrin antagonist
Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).- Higuchi S, .et al. , Dev Growth Differ, 2016, Sep;58(7):586-99 PMID: 27633818
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GpIIb/IIIa antagonist
GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist. -
glycoprotein IIb/IIIa antagonist
Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; Kd = 120 nM) that inhibits platelet aggregation. -
LFA-1 Antagonist
BMS-688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1). -
LFA-1 antagonist
Lifitegrast (SAR 1118) is an integrin lymphocyte function-associated antigen-1 (LFA-1) antagonist; inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. -
platelet glycoprotein IIb/IIIa antagonist
Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. -
α4β1/α4β7 integrin antagonist
Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders. -
integrin αvβ3 antagonist
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent. -
integrin α5β1 antagonist
ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
