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Cytoskeleton

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Items 1-50 of 481

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  1. A11435
    GSK-923295

    CENP-E inhibitor

    GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E).
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  2. A13647
    (-)-Blebbistcitin

    myosin II inhibitor

    Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.
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  3. A13838
    LOR-253

    MTF-1 inhibitor

    LOR-253 is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1).
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  4. A13219
    Nocodazole

    microtubule inhibitor

    Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.
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  5. A11449
    Ixabepilone

    microtubule inhibitor

    Ixabepilone is an epothilone B analog
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  6. A12553
    FRAX597

    PAK inhibitor

    FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
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  7. A12037
    Luvixasertib (CFI-402257)

    TTK inhibitor

    CFI-402257, a pyrazolopyridin derivative, has been found to be a TTK inhibitor that could influence chromosome segregation and induce cell death so that is significant in anticancer studies.
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  8. A20973
    CK-666

    Arp2/3 complex inhibitor

    CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.
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  9. A14923
    Cyclo (-RGDfK)

    αvβ3 integrin inhibitor

    Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
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  10. A11170
    AZ 3146

    Mps1 inhibitor

    AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

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  11. A15538
    RGD (Arg-Gly-Asp) Peptides

    Inhibits integrin binding to RGD motifs

    RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
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  12. A14288
    (E)-KN-93 phosphate

    CaMKII inhibitor

    KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
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  13. A15915
    Dyngo-4a

    Dynamin inhibitor

    Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 uM, 1.1uM, and 2.3 uM for DynI (brain), DynI (rec), and DynII (rec), respectively.
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  14. A12372
    Cilengitide

    Integrin inhibitor

    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
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  15. A13691
    FRAX486

    PAK inhibitor

    FRAX486 is a small-molecule PAK inhibitor.
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  16. A10689
    Paclitaxel (Taxol)

    Microtubule Associated inhibitor

    Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.
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  17. A11936
    ML 7 hydrochloride

    MLCK inhibitor

    ML 7 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK).
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  18. A11831
    Cabazitaxel

    Microtubule Associated inhibitor

    Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment
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  19. A10326
    Docetaxel (Taxotere)

    Microtubule Associated inhibitor

    Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.
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  20. A17185
    Obtustatin

    α1β1 inhibitor

    Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
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  21. A14316
    Mdivi-1

    DRP1 inhibitor

    Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.
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  22. A12726
    Dynasore

    Dynamin inhibitor

    Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity
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  23. A12371
    Cilengitide trifluoroacetate

    Integrin inhibitor

    Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
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  24. A10360
    Epothilone B (EPO906)

    Microtubule Associated inhibitor

    Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
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  25. A11218
    Mps1-IN-1

    Mps1 inhibitor

    Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
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  26. A11930
    PF-3758309

    PAK4 inhibitor

    PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth.
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  27. A11976
    Monastrol

    Kinesin-5(KIF11) inhibitor

    Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
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  28. A13584
    A-3 Hydrochloride

    PKA, PKG, Casein Kinase I and II inhibitor

    A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
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  29. A13661
    Vinblastine sulfate

    microtubule dynamics inhibitor

    Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer.
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  30. A13735
    CW069

    Microtubule Associated inhibitor

    CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
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  31. A13800
    MS-444

    MLCK inhibitor

    MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM.
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  32. A13827
    CK-636

    Arp2/3 inhibitor

    CK-636 is a Arp2/3 complex inhibitor. CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation.
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  33. A13872
    INH1

    Hec1 imhibitor

    INH1 is a Hec1 inhibitor. It binds Hec1, inhibiting its association with Nek2 and kinetochores.
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  34. A14200
    INH6

    Hec1 Inhibitor

    INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
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  35. A14234
    ARQ 621

    Eg5 mitotic motor protein inhibitor

    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.
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  36. A14290
    MPI-0479605

    Mps1 inhibitor

    MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1
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  37. A14442
    D-64131

    Tubulin inhibitor

    D-64131 is a novel inhibitor of tubulin polymerization that inhibits tumor cell proliferation in vitro (IC50 = 74 nM).
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  38. A17010
    Crolibulin

    tubulin polymerization inhibitor

    Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
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  39. A17184
    R-BC154 acetate

    α4β1/α9β1 inhibitor

    R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor.
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  40. A17193
    TCS2314

    Integrin Inhibitor

    TCS2314 is a integrin very late antigen-4 (VLA-4; α4β1) antagonist with IC50 value of 4.4 nM.
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  41. A17200
    BTT-3033

    α2β1 integrin inhibitor

    BTT-3033 is a α2β1 integrin inhibitor.
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  42. A17201
    BOP sodium salt

    α9β1/α4β1 integrin inhibitor

    BOP sodium salt is a novel dual alpha9beta1/alpha4beta1 integrin inhibitor.
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  43. A17203
    BIO-5192

    VLA-4 inhibitor

    BIO-5192 is a small molecule VLA-4 inhibitor.
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  44. A17208
    RWJ 50271

    LFA-1 inhibitor

    RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1).
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  45. A17210
    BIO-1211

    Integrin alpha4beta1 inhibitor

    BIO-1211 is an integrin alpha4beta1 inhibitor.
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  46. A17211
    A 286982

    LFA-1/ICAM-1 interaction inhibitor

    A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction with IC50 valueof 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion, respectively.
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  47. A17856
    ML-9 hydrochloride

    MLCK inhibitor

    ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation.
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  48. A18350
    SSE15206

    Microtubule/Tubulin Inhibitor

    SSE15206 is a pyrazolinethioamide derivative that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents.
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  49. A15841
    Dimethylenastron

    Kinesin Eg5 inhibitor

    Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.
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  50. A15844
    K 858

    Kinesin Eg5 inhibitor

    K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM.
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