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Fig. 1 · Structure
Cat. No.
A21254
CAS No.
501948-05-6
Formula
C22H16N4O2S
Mol. Weight
400.45

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Rosabulin

Cat. No. A21254 CAS 501948-05-6

microtubule inhibitor

Rosabulin is a potent microtubule inhibitor, with anti-cancer activities.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
DU-145 IC50 0.05 μM Cytotoxicity against human DU145 cells after 72 hrs by MTT assay [PMID: 18308566]
HL-60 IC50 0.05 μM Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [PMID: 18308566]
MDA-MB-435 IC50 0.05 μM Cytotoxicity against human MDA435 cells after 72 hrs by MTT assay [PMID: 18308566]
MES-SA IC50 0.01 μM Cytotoxicity against human MESSA cells after 72 hrs by MTT assay [PMID: 18308566]
MES-SA/Dx5 IC50 0.05 μM Cytotoxicity against human MESSA/DX5 cells after 72 hrs by MTT assay [PMID: 18308566]
P388 IC50 0.01 μM Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay [PMID: 18308566]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 501948-05-6
Applications microtubule inhibitor
Formula C22H16N4O2S
Molecular Weight 400.45
Synonyms STA 5312
SMILES
O=C(NC1=CC(C)=NS1)C(C2=C3C=CC=CN3C(CC4=CC=C(C#N)C=C4)=C2)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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