DNA Damage

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  1. Nucleoside Metabolite

    4-Hydroxy-2-oxopentanoic acid is a nucleoside metabolite that plays a crucial role in cellular metabolism. It serves as an intermediate in various biochemical pathways, influencing nucleoside synthesis and metabolism. This compound can be utilized in research exploring metabolic regulation, nucleic acid synthesis, and the physiological effects of nucleoside derivatives.
  2. Purine Nucleoside Analog

    5’-Azido-5’-deoxy-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, making it a versatile tool for various chemical biology applications.
  3. Plant Growth Promoter

    3-Indoleglycolaldehyde is a bacterial metabolite that functions as a plant growth promoter. This compound has been shown to enhance plant growth and development, making it valuable for agricultural and horticultural research. Its unique properties may aid in studying plant biology and exploring sustainable agricultural practices.
  4. Oligonucleotide

    m7GpppCpG is an oligonucleotide and a cap analogue of the M7GpppNpG trinucleotide. This compound serves as a valuable chemical tool for the production of RNA with cap 0 or cap 1 structures, facilitating studies in RNA biochemistry and gene expression regulation. Its application is critical in the development of mRNA therapeutics and advanced RNA-based research methodologies.
  5. Nucleoside Metabolite

    Avicholic acid is a nucleoside metabolite that plays a significant role in cellular metabolism. It has been implicated in various biochemical pathways, making it a valuable tool for research in nucleoside signaling and metabolism. Avicholic acid is used in studies exploring its effects on cellular processes and potential therapeutic applications in related metabolic disorders.
  6. Uridine Analog

    3-(2-Pyridinylmethyl)uridine is a uridine analog that serves as a valuable tool for biochemical research. This compound exhibits potential antiepileptic effects, making it useful for studying anticonvulsant and anxiolytic activities. Additionally, it offers opportunities for the development of novel antihypertensive agents, contributing to a better understanding of various neurological and cardiovascular functions.
  7. Nucleoside Analog

    N4-Methyl-CTP is a nucleoside analog that serves as a monomeric substrate for nucleic acid synthesis. This compound can be incorporated into RNA and DNA strands, facilitating studies in molecular biology, gene editing, and therapeutic development. Its unique methyl group may also influence nucleotide interactions, making it valuable for exploring nucleic acid structure and function.
  8. Nucleoside Analog

    dITP (2'-Deoxyinosine-5'-triphosphate) is a nucleoside analog that serves as a building block for nucleic acid synthesis. Its key biological activity involves incorporation into DNA by DNA polymerases, enabling studies of DNA replication and repair mechanisms. dITP is widely used in molecular biology applications, including site-directed mutagenesis, nucleotide labeling, and the generation of modified nucleic acids for various research purposes.
  9. Nucleoside Analog

    CTPαS (Rp isomer) is a nucleoside analog that serves as a critical monomer in nucleic acid synthesis. This compound is utilized in biochemical research for the development of RNA and DNA-based constructs, facilitating studies on genetic expression and molecular interactions. Its unique structure allows for incorporation into oligonucleotides, enabling advanced applications in genomics and therapeutics.
  10. Nucleoside Analog

    EX-A8186 is a nucleoside analog designed for the synthesis of nucleic acids. This monomeric compound serves as a building block in various biochemistry applications, including the development of oligonucleotides and DNA/RNA sequencing. Its utility in the production of nucleic acid constructs makes it valuable for research in molecular biology, genetic engineering, and therapeutic development.
  11. Nucleoside Analog

    3′-Azido-ddATP is a potent nucleoside analog that serves as a key monomer for nucleic acid synthesis. This compound, featuring an azido group at the 3′ position, is instrumental in research applications focused on developing modified nucleotides for various biochemical studies, including DNA sequencing and molecular biology techniques. Its unique structure allows for incorporation into nucleic acids, facilitating the exploration of nucleic acid interactions and functions.
  12. Malic acid Derivative

    (2R,3S)-3-Methylmalic acid is a malic acid derivative that serves as a valuable synthon for the synthesis of 2-methyl-3-hydroxy-butyrolactones. This compound demonstrates significant utility in organic synthesis and is applicable in the development of various pharmaceuticals and bioactive molecules. Its structural characteristics make it a key intermediate in research focused on the synthesis of complex organic compounds.
  13. Nucleoside Analog

    3'-O-TBDMS-2'-O-Me-rG(iBu) is a nucleoside analog that serves as a valuable monomeric precursor for nucleic acid synthesis. This compound enhances the stability and solubility of oligonucleotides, making it ideal for a variety of molecular biology applications. It is particularly useful in the synthesis of modified RNA molecules and can facilitate studies in gene expression, RNA interference, and other RNA-based technologies.
  14. Nucleoside Analog

    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite is a nucleoside analog designed for incorporation into oligonucleotides during nucleic acid synthesis. This reagent features a DMTr protecting group and can facilitate the addition of sulfur at the 3' position, enhancing the stability and functionality of synthesized nucleic acids. It is ideal for applications in therapeutic and diagnostic research involving nucleic acid-based technologies.
  15. Nucleoside Analog

    2'-Deoxy-3',5'-GDP (pdGp) is a nucleoside analog that serves as a crucial monomer for nucleic acid synthesis. Its structure allows for incorporation into RNA and DNA, facilitating studies on nucleic acid behavior and functions. This reagent is essential for various biochemical applications, including the development of oligonucleotides and the exploration of enzymatic mechanisms involving nucleotides.
  16. Nucleoside Analog

    DMTr-2'-F-dU-3'-(L)-DPSE-phosphoramidite is a nucleoside analog designed for applications in nucleic acid synthesis. This phosphoramidite serves as a key building block for the preparation of modified oligonucleotides, enabling the introduction of fluorinated bases into nucleic acids. Its unique properties facilitate diverse research applications, including the study of gene expression and the development of RNA therapeutics.
  17. Nucleoside Analog

    5-OH-CTP (5-hydroxy cytidine triphosphate) is a nucleoside analog that serves as a vital building block in nucleic acid synthesis. Its unique structure allows it to incorporate into RNA, facilitating various biochemical and biophysical studies. This reagent is applicable in research focused on RNA synthesis, enzymatic reactions, and the investigation of nucleic acid interactions.
  18. Purine Nucleoside Analog

    3’-O-Methyl inosine is a purine nucleoside analog known for its potent antitumor activity. This compound primarily targets indolent lymphoid malignancies through mechanisms that include inhibition of DNA synthesis and induction of apoptosis. It serves as a valuable tool in cancer research, advancing the understanding of therapeutic approaches against various tumors.
  19. Nucleoside Analog

    DMTr-dA(dmf)-3'-CE-phosphoramidite is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. It facilitates the construction of oligonucleotides through phosphoramidite chemistry, enabling the incorporation of modified nucleotides. This reagent is essential for researchers studying gene expression, RNA interference, and the development of antisense oligonucleotides.
  20. Nucleoside Analog

    dGDP sodium (2'-Deoxyguanosine-5'-diphosphate sodium) serves as a nucleoside analog, functioning as a vital building block for nucleic acid synthesis. Its incorporation into oligonucleotides allows for the exploration of molecular biology applications, including genetic engineering and the study of nucleotide metabolism. This reagent is essential for researchers working on synthetic biology and therapeutic development.
  21. Nucleoside Analog

    5'-O-DMTr-3'-O-Me-rA(Bz) is a nucleoside analog characterized by its protective groups that facilitate nucleic acid synthesis. This compound serves as a key monomer for the construction of oligonucleotides, enabling precise modifications during the synthesis process. Its structural components support improved stability and compatibility in various biochemical applications, making it valuable for nucleic acid research and development.
  22. Nucleoside Analog

    LNA-AMP is a nucleoside analog that serves as a building block for the synthesis of oligonucleotides. This compound enhances the stability and affinity of nucleic acid interactions, making it valuable for applications in molecular biology, gene expression studies, and antisense research. Its unique properties facilitate the design of more effective RNA-targeting therapeutics and diagnostics.
  23. Nucleoside Analog

    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rC(Ac) is a nucleoside analog that serves as a key monomeric building block for nucleic acid synthesis. It features a unique protection group, making it suitable for various chemical modifications in the synthesis of RNA and DNA oligonucleotides. This compound is particularly useful in studies related to synthetic biology, gene therapy, and RNA interference research.
  24. Nucleoside Analog

    dCTPαS (2'-Deoxycytidine-5'-O-(1-thiotriphosphate)) is a nucleoside analog that serves as a monomeric building block for nucleic acid synthesis. This compound plays a critical role in the incorporation of modified nucleotides into DNA and RNA, facilitating research in genetic engineering, molecular cloning, and the development of nucleotide-based therapeutics. Its unique thiophosphate structure enhances stability and reactivity, making it a valuable tool for various biochemical assays and studies.
  25. DNA Polymerases Substrate

    Troxacitabine triphosphate (TRX-TP) serves as a substrate for DNA polymerases, specifically targeting replicative and repair enzymes. This compound demonstrates key biological activity by facilitating DNA synthesis and repair processes in vitro. It is valuable for research applications that involve the study of nucleotide incorporation and polymerase activity, providing insights into DNA replication and repair mechanisms.
  26. Nucleoside Analog

    3'-ONH₂-dUTP is a nucleoside analog that serves as a building block for nucleic acid synthesis. It is utilized in various molecular biology applications, including the incorporation of modified nucleotides into DNA or RNA strands. Its unique chemical properties allow for enhanced stability and potential applications in genetic engineering and therapeutic development.
  27. Nucleoside Analog

    DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-phosphoramidite is a modified nucleoside analog designed for use in nucleic acid synthesis. This phosphoramidite serves as a building block for oligonucleotide formation, facilitating the incorporation of modified nucleotides into RNA and DNA sequences. Its unique structural features enhance the stability and performance of nucleic acids in various research applications, including gene expression studies and therapeutic development.
  28. Nucleoside Analog

    LNA-CTP is a nucleoside analog that acts as a structural component in the synthesis of oligonucleotides. Its incorporation into oligonucleotides enhances their stability and binding affinity to complementary strands. This makes LNA-CTP valuable for applications in molecular biology, including gene expression analysis, antisense oligonucleotide design, and gene editing research.
  29. Nucleoside Analog

    6-Chloropurine-2'-deoxyriboside is a nucleoside analog that acts as a purine derivative. It is utilized in the synthesis of nucleic acids, serving as a building block in the creation of DNA sequences. This compound has applications in molecular biology research, particularly in studies of nucleic acid metabolism and the development of antiviral therapies.
  30. Nucleoside Analog

    Rp-TTPαS is a nucleoside analog that serves as a potent monomeric raw material for nucleic acid synthesis. This compound is critical for research applications involving the production of oligonucleotides and can enhance the efficiency of nucleotide incorporation during polymerization processes. Its unique structure allows for the exploration of modified nucleic acids, facilitating studies in molecular biology and gene editing technologies.
  31. Nucleoside Analog

    N2-DMF-2'-O-Methylguanosine is a nucleoside analog that serves as a valuable monomeric raw material for nucleic acid synthesis. Its 2'-O-methyl modification enhances stability and resistance to nucleases, making it useful for various applications in molecular biology, including the construction of modified RNA and the study of RNA-protein interactions. This compound is instrumental in advancing the development of therapeutic nucleic acids and RNA-based research.
  32. Uridine Analog

    4’-α-C-Methyluridine is a uridine analog that acts on purinergic signaling pathways. It exhibits potential antiepileptic properties, making it useful for investigating anticonvulsant and anxiolytic activities. This compound may also facilitate the development of new antihypertensive agents, offering insights into cardiovascular research applications.
  33. Nucleotide Analogue

    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine is a nucleotide analogue that serves as a key building block in nucleic acid synthesis. This compound is designed to enhance the efficiency and specificity of oligonucleotide assembly, making it valuable in genetic research and therapeutic applications. Its unique structural modifications facilitate improved stability and integration into nucleic acid sequences, supporting advances in gene editing and molecular diagnostics.
  34. Purine Nucleoside Analog

    4′-Thiocytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research and therapeutic studies.
  35. Nucleoside Analog

    LNA-ATP is a nucleoside analog that serves as a vital building block in the synthesis of oligonucleotides. Its unique structure enhances the affinity and stability of nucleic acid interactions, making it valuable for applications in molecular biology, including gene editing, RNA studies, and the development of antisense oligonucleotides. Researchers utilize LNA-ATP to improve the efficacy and specificity of nucleic acid-based technologies.
  36. Nucleoside Analog

    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one is a nucleoside analog that exhibits mutagenic properties in Escherichia coli and Salmonella typhimurium. This compound induces GC to AT transitions through replication errors, contributing to its significance in mutagenesis studies. Additionally, it demonstrates stability in bacterial systems and can be detected at wavelengths exceeding 300 nm, making it a valuable tool for research related to DNA replication and mutation mechanisms.
  37. Nucleoside Analog

    3',5'-O-TIPDS-2'-spirocyclopropyl-U is a nucleoside analog specifically designed for use in nucleic acid synthesis applications. Its unique structure allows for incorporation into oligonucleotides, facilitating studies in RNA interference and gene expression regulation. This compound is valuable in the development of novel therapeutics and in exploring the functional roles of modified nucleotides in molecular biology.
  38. Thymidine Analogue

    5-Amino-2'-deoxyuridine is a thymidine analogue that serves as a substrate in various chemical reactions. It is primarily utilized in the synthesis of labeled probes for DNA microarray analysis, facilitating the study of gene expression and genomic variations. This compound is instrumental in nucleic acid research, providing a valuable tool for molecular biology applications.
  39. Nucleoside Analog

    LNA-GDP is a nucleoside analog characterized by its incorporation into oligonucleotides, enhancing their stability and affinity for complementary strands. This compound plays a crucial role in various molecular biology applications, including gene editing, antisense technology, and the design of therapeutic oligonucleotides. Its unique structural features contribute to increased resistance against enzymatic degradation, making it a valuable tool for researchers in nucleic acid chemistry.
  40. Nucleoside Analog

    3′-O-Azidomethyl-dAMP is a nucleoside analog that serves as a monomeric substrate for nucleic acid synthesis. This compound is instrumental in the preparation of modified oligonucleotides and can be utilized in various biochemical applications such as gene editing, and the development of diagnostic tools. Its unique azido group facilitates subsequent reactions in click chemistry, enhancing functionalization possibilities in molecular biology research.
  41. Nucleoside Analog

    3'-OMe-m7GMP is a nucleoside analog that serves as a vital monomeric building block in nucleic acid synthesis. Its modified structure enhances stability and incorporation into nucleic acid polymers, making it useful for studies in molecular biology and genetic engineering. This compound supports research in RNA synthesis and the development of therapeutic oligonucleotides.
  42. Nucleoside Analog

    2'-OMe-CTP is a nucleoside analog that serves as a monomer for nucleic acid synthesis. This modified nucleotide exhibits enhanced nucleotide stability and improved binding affinity, making it useful in the development of ribonucleic acid (RNA) therapeutics and diagnostic applications. Its incorporation into oligonucleotides can enhance RNA's resistance to enzymatic degradation, facilitating studies in molecular biology and genetic engineering.
  43. Nucleoside Analog

    5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) is a nucleoside analog designed for use in nucleic acid synthesis. This compound features a protective group that ensures stability and efficiency during oligonucleotide assembly. Its unique structure facilitates the incorporation of modified ribonucleotides, making it valuable for advancing research in molecular biology and genetic engineering.
  44. Nucleoside Analog

    2'-F-CDP is a nucleoside analog that serves as a key building block in the synthesis of oligonucleotides. Its fluorinated structure enhances metabolic stability and may improve the pharmacokinetic properties of RNA-based therapeutics. This compound is valuable in research applications such as oligonucleotide design and development, enabling advancements in gene therapy and RNA interference studies.
  45. Nucleoside Analog

    Im-3'-OMe-GMP is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. It demonstrates stability and incorporation in RNA and DNA processes, making it suitable for investigating cellular functions and developing therapeutics. This compound is valuable in the study of gene expression, oligonucleotide design, and other applications in nucleic acid research.
  46. Guanosine Nucleoside

    N-Acetyl-2',3'-acetyl-guanosine is a modified guanosine nucleoside that serves as a substrate for various enzymatic processes. This compound is utilized in biochemical research to study nucleoside metabolism and nucleotide synthesis. Its unique acetyl modifications enhance solubility and stability, making it suitable for exploring nucleoside interactions and applications in RNA biochemistry.
  47. Nucleoside Analog

    3'-ONH2-dGTP is a nucleoside analog that serves as a crucial monomeric substrate for nucleic acid synthesis. Its unique chemical structure allows for incorporation into DNA and RNA, facilitating studies in molecular biology, genetic engineering, and pharmacology. This reagent is instrumental for researchers exploring nucleotide modifications and their implications in various biological processes.
  48. Nucleoside Analog

    5'-O-DMTr-2'-O-(2-Aminoethyl)-5-Me-rU is a nucleoside analog that serves as a key monomer in nucleic acid synthesis. This compound can facilitate the incorporation of modified ribonucleotides into RNA, enhancing the stability and functionality of oligonucleotides. It is particularly valuable in research applications involving RNA therapeutics and the development of novel RNA-based biomolecules.
  49. Thymidine Analog

    5-(3-Azidopropyl)uridine is a thymidine analog that displays insertional activity towards replicated DNA, making it valuable in studies of DNA synthesis and cellular labeling. This compound features an azide group, allowing it to function as a click chemistry reagent. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, and also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating diverse applications in chemical biology.
  50. Nucleoside Analog

    Fluorescein-12-dUTP is a nucleoside analog that serves as a fluorescently labeled deoxyuridine triphosphate. Its primary mechanism involves incorporation into nucleic acids during DNA synthesis, facilitating the visualization of nucleic acids in various applications. This reagent is particularly valuable in molecular biology techniques such as DNA labeling, in situ hybridization, and studying gene expression.

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