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2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside

Purine Nucleoside Analog

2-Amino-6-chloropurine-9-(2’-O-propargyl)riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent due to the presence of an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, facilitating various bioconjugation applications in chemical biology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2095417-35-7
Applications	Purine Nucleoside Analog
Formula	C₁₃H₁₄ClN₅O₄
Molecular Weight	339.73
SMILES	O[C@H]1[C@@H](OCC#C)[C@H](N(C=N2)C3=C2C(Cl)=NC(N)=N3)O[C@@H]1CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.