Catalog No.
Product Name
Application
Product Information
Citations
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Nucleoside Analog
Fluorescein-12-UTP is a nucleoside analog that serves as a fluorescent label for RNA synthesis. Its primary application lies in the incorporation into RNA transcripts during in vitro transcription, allowing for the visualization and tracking of RNA molecules. This reagent is widely used in studies involving RNA localization, expression analysis, and other molecular biology applications. -
Nucleoside Analog
DMTr-2',2'-diFluoro-dA(Bz)-3'-CE-phosphoramidite is a nucleoside analog utilized as a key monomer in oligonucleotide synthesis. This compound exhibits unique properties due to the presence of di-fluorinated modifications, enhancing the stability and affinity of nucleic acids. It serves as an essential building block for the development of modified oligonucleotides in various research applications, including gene therapy and molecular diagnostics. -
Nucleoside Analog
Reverse abasic phosphoramidite is a nucleoside analog designed for use in nucleic acid synthesis. This compound serves as a monomeric raw material, facilitating the incorporation of abasic sites into oligonucleotides. Its unique properties make it valuable for studying the biochemical effects of abasic sites in DNA and RNA, enabling research in fields such as molecular biology and genetics. -
Oligonucleotide
m7GpppGpG is an oligonucleotide that functions as an M7GpppNpG trinucleotide cap analogue. It effectively prevents premature degradation by 5′-exonucleases, thus stabilizing RNA molecules. Additionally, m7GpppGpG plays a crucial role in recruiting proteins essential for pre-mRNA splicing, mRNA transport, and the initiation of protein biosynthesis, making it valuable for various molecular biology and RNA research applications. -
Nucleoside Analog
DMTr-2'-O-Me-rG(iBu)-3'-(L)-DPSE-phosphoramidite is a nucleoside analog primarily used as a monomer for nucleic acid synthesis. This compound facilitates the incorporation of modified nucleotides into oligonucleotide sequences, allowing researchers to study the structural and functional properties of nucleic acids. Its unique modifications enhance stability and binding characteristics, making it valuable in various applications, including antisense research, gene therapy, and RNA interference studies. -
Nucleoside Analog
2′-O-MOE-CMP is a nucleotide analog specifically designed for oligonucleotide synthesis. This compound functions by enhancing the stability and affinity of nucleic acid constructs, making it useful in various molecular biology applications. Its incorporation into oligonucleotides can improve resistance to nucleases and enhance binding properties, facilitating research in gene expression and antisense oligonucleotides. -
Nucleotide
3′-GMP is a nucleotide involved in various biological processes, including RNA synthesis and signaling. It serves as a phosphoribosyl donor and plays a critical role in cellular metabolism. Research applications of 3′-GMP include studies on nucleotide metabolism, enzyme activity, and signal transduction pathways. -
Nucleoside Analog
2'-O-Propargyl-rC(Ac) is a nucleoside analog that serves as a versatile monomer for nucleic acid synthesis. Its propargyl group facilitates various chemical modifications, enhancing the structural diversity of RNA molecules. This compound is valuable for applications in RNA research, including the development of RNA probes and therapeutic oligonucleotides. -
Nucleoside Analog
DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-phosphoramidite is a nucleoside analog designed for use in nucleic acid synthesis. This phosphoramidite serves as a monomeric building block, enabling the incorporation of modified nucleotides into oligonucleotides. Its application extends to various research areas, including gene delivery and RNA therapeutics development. -
Nucleoside Analog
DMTr-2'-O-propyl-rG(iBu)-3'-CE-phosphoramidite is a nucleoside analog specifically designed for oligonucleotide synthesis. This phosphoramidite derivative enables the incorporation of modified guanine residues into nucleic acid sequences, enhancing their properties for various research applications. It is particularly valuable for studies involving antisense oligonucleotides, RNA interference, and the development of nucleic acid-based therapeutics. -
Nucleoside Analog
N2-Isobutyryl-2'-O,4'-C-methyleneguanosine is a nucleoside analog designed for use in nucleic acid synthesis. This compound features a unique modified structure that enhances its stability and incorporation into RNA sequences, making it an essential reagent for studies in molecular biology and genetic engineering. Its applications extend to investigating RNA function, structure, and the development of novel therapeutics. -
Nucleoside Analog
DMTr-2'-F-dG(iBu)-3'-(L)-DPSE-phosphoramidite is a nucleoside analog that serves as a key building block for nucleic acid synthesis. This compound is designed to facilitate the incorporation of modified nucleotides into oligonucleotide sequences, enhancing stability and specificity. Its applications include the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics, making it valuable for research in gene regulation and molecular biology. -
Nucleoside Analog
5'-O-DMTr-2'-O-Me-rA is a nucleoside analog that serves as a versatile building block for nucleic acid synthesis. Its unique chemical modifications enhance stability and efficacy in various biochemical applications. This compound is instrumental in the development of modified oligonucleotides, enabling advancements in RNA therapeutics and molecular biology research. -
Nucleoside Analog
N-Butyl molnupiravir is a nucleoside analog that serves as a crucial building block for nucleic acid synthesis. This compound exhibits antiviral properties and has potential applications in virology research, particularly in the development of therapeutics against RNA viruses. Its modification allows for enhanced stability and effectiveness in various experimental settings. -
Nucleoside Analog
SPS ATP is a nucleoside analog that serves as a critical monomeric substrate in nucleic acid synthesis. Its incorporation into RNA and DNA strands enables the study of nucleic acid structure and function. This reagent is essential for applications in molecular biology, including the development of RNA therapies and the exploration of genetic mechanisms. -
Nucleoside Metabolite
3α,7α-Dihydroxycoprostane is a nucleoside metabolite derived from cholest-4-en-3-one-7α-ol. This compound exhibits biological activity relevant to lipid metabolism and can be instrumental in studying the pathways involved in steroid biosynthesis. Its applications extend to research focused on endocrine function and metabolic diseases, providing essential insights into the biological roles of sterols in cellular processes. -
Nucleoside
5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a modified nucleoside that features a 5' oxygen dimethyl group and a 2' methyl substitution. It exhibits significant affinity for tissues, demonstrated through chemotactic assays, making it a valuable tool for investigating nucleoside transport and cellular localization. This compound is useful in various research applications, including studies of nucleoside metabolism and signaling pathways. -
Purine Nucleoside Analog
5-Ethyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in the treatment of indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool for research applications focusing on cancer therapy and the understanding of cancer cell metabolism. -
Nucleoside
2'-Deoxy-L-guanosine is a nucleoside that selectively inhibits the phosphorylation of D-Thymidine catalyzed by herpes simplex virus type 1 (HSV-1) thymidine kinase. This compound serves as a valuable tool in studying viral infection mechanisms and nucleoside metabolism. Its unique structure and inhibitory properties make it suitable for research applications in virology and nucleoside biochemistry. -
Nucleoside Analog
iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog targeting DNA synthesis. It serves as a key building block for the production of oligoribonucleotides, facilitating research in molecular biology and genetic engineering. iBu-dG is valuable for studies involving nucleotide modification and nucleic acid structures. -
Nucleoside Analog
DMTr-2'-O-C22-rU-3'-CE-phosphoramidite is a nucleoside analog designed for the efficient synthesis of oligonucleotides. This compound serves as a key building block in the construction of RNA sequences, enabling studies in gene expression, RNA interference, and other nucleic acid-based research applications. Its unique 2'-O modification enhances stability and binding properties, making it valuable for various experimental designs in molecular biology. -
Cap Reagent
Im-m7GDP sodium is a cap reagent that facilitates the synthesis of modified nucleic acids. This compound is essential for the incorporation of a methyltetrahydro-2H-pyran-2-yl group into the 5' end of RNA, enhancing stability and translation efficiency. It is widely utilized in the production of mRNA for vaccine development and other therapeutic applications. -
Nucleoside Antimetabolite/Analog
2'-O-(2-Methoxyethyl)-uridine is a nucleoside analog that acts as an antimetabolite, specifically targeting RNA synthesis. This synthetic compound exhibits significant potential in the development of chemotherapeutic agents, making it a valuable tool for research in cancer therapeutics and RNA-related studies. Its structural modifications enhance stability and bioavailability, offering insights into nucleoside pharmacology and mechanism of action. -
dTTP Precursor
dUDP disodium is a nucleotide that serves as a key precursor for the synthesis of dTTP. Composed of a uracil base, ribose, and two phosphate groups, dUDP disodium is utilized as a substrate for deoxyuridine triphosphate nucleotide hydrolase, facilitating the conversion of dUDP to dUMP, the direct precursor for dTTP synthesis. This compound is integral to DNA synthesis and is applicable in diverse biochemical analyses and research applications focused on nucleotide metabolism. -
Purine Nucleoside Analog
5'-Deoxy-5'-iodouridine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and induction of apoptosis, making it a valuable compound in cancer research. This reagent is applicable in studies focused on the mechanisms of tumor cell proliferation and therapeutic resistance. -
DNA-binding agent
Centanamycin is a novel DNA-binding agent that exhibits significant cytotoxic activity, demonstrated by an average GI50 of 34 nM in the NCI-60 cancer cell line panel. Its mechanism targets DNA, making it a valuable compound for research in cancer biology and therapeutic development. Centanamycin can be utilized to explore DNA-interactive processes and the underlying mechanisms of action in cellular responses to DNA damage. -
Adenosine Analog
DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenosine analog designed for use in oligonucleotide synthesis. This compound functions as a building block for the incorporation of 2'-O-methyl modifications into RNA sequences. Its primary biological activity enables researchers to explore the effects of modifications on RNA stability, structure, and function, making it valuable for studies in molecular biology and therapeutic development. -
Purine Nucleoside Analog
7’-OH-N-trityl morpholinothymine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis, making it valuable in cancer research. Its application in studies focusing on nucleoside metabolism and tumor biology provides essential insights into therapeutic strategies for lymphoid cancers. -
Uridine Analog
2'-C-methyluridine is a uridine analog that interacts with various biological pathways. It exhibits potential anticonvulsant and anxiolytic effects, making it valuable for studying epilepsy and anxiety disorders. Additionally, it can be explored for the development of novel antihypertensive agents, contributing to research in cardiovascular health. -
Nucledside Analogue
2'-Deoxy-β-L-uridine is a nucleoside analogue that serves as a specific substrate for the viral enzyme, demonstrating no stereospecificity against herpes simplex virus type 1 (HSV1) thymidine kinase. This compound exhibits antiviral activity through the interaction of its 5'-triphosphate form with viral DNA polymerase, thereby inhibiting viral replication. It is a valuable tool in studying HSV1 and other viral infections, as well as in developing antiviral therapies. -
Purine Nucleoside Analog
2-Hydrazinyl-adenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanism primarily involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research aimed at understanding and treating various cancers. This reagent is suitable for studies focused on cancer biology and the development of novel therapeutic strategies. -
Nucleoside Analogue
2,3-O-Isopropylidene-D-ribonolactone is a nucleoside analogue that serves as an acetonide derivative of D-ribonolactone. It is primarily utilized as an intermediate in organic synthesis, formed through the acid-catalyzed acetalization of D-ribonolactone with acetone. This compound plays a critical role in the production of 1,5-dideoxy-1,5-imino-D-ribitol and 1,5-dideoxy-1,5-imino-L-arabinitol, making it valuable for various biochemical applications and research endeavors. -
Purine Nucleoside Analog
5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite is a purine nucleoside analog that targets DNA synthesis pathways. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. The compound's mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and drug development. -
Nucleoside Analog
2′,3′-Di-O-acetylguanosine is a nucleoside analog that mimics natural guanosine. It exhibits potential as an antiviral agent and is utilized in biochemical research to study nucleoside metabolism and cellular processes. This compound is relevant for exploring mechanisms of RNA synthesis and functions, making it a valuable tool in molecular biology and therapeutic development research. -
Adenosine Analog
N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is an adenosine analog that primarily targets adenosine receptors. It exhibits significant vasodilatory effects by relaxing smooth muscle and has demonstrated potential in inhibiting cancer progression. This compound is valuable in biomedical research, particularly in studies focused on cardiovascular health and cancer therapy. -
Thymidine Analog
1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog serving as an important tool in molecular biology research. It exhibits insertional activity towards replicated DNA, making it useful for labeling cell populations and monitoring DNA synthesis. This compound has applications in studies of nucleic acid metabolism and cell proliferation. -
Purine Nucleoside Analog
2'-Deoxyisoguanosine is a purine nucleoside analog that demonstrates potential inhibitory effects on tumor cell growth. It acts by targeting telomerase, a critical enzyme for cellular immortality in cancer cells. Although exhibiting low potency and specificity, it serves as a valuable tool for research in cancer biology and the study of telomerase function. -
Purine Nucleoside Analog
3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound operates primarily through the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. Its unique mechanisms make it a valuable tool for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily through the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. Its ability to mimic natural nucleosides allows for the exploration of therapeutic strategies targeting tumor cells. -
Purine Nucleoside Analog
8-Methyl-2’-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology. This compound is suitable for studies aimed at exploring therapeutic strategies involving purine metabolism and nucleoside analogs. -
Adenosine Nucleoside
8-Methyladenosine is a modified adenosine nucleoside that exerts its effects through methylation at the 8-position. This modification imparts resistance to five classes of antibiotics that target the ribosomal peptidyl transferase center, making it a valuable tool in research on antibiotic-resistant bacterial infections. Its unique properties make it essential for understanding the mechanisms of resistance and developing strategies to counteract such infections. -
Nucleoside Antimetabolite/Analog
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is a nucleoside antimetabolite and analog that serves as a valuable intermediate for synthesizing oligodeoxynucleotides with 3'-S-phosphorothiolate linkages. This compound is instrumental in studying enzyme-catalyzed cleavage processes within DNA, aiding in the investigation of nucleic acid interactions and mechanisms. Its structural features enhance its utility in various genetic and molecular biology research applications. -
Purine Nucleoside Analog
N6-Ethyl-2’-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism includes the inhibition of DNA synthesis, which plays a crucial role in inducing apoptosis. This compound is valuable for research applications aimed at investigating cancer biology and developing therapeutic strategies for lymphoid malignancies. -
Purine Nucleoside Analog
5-Iodouridine is a purine nucleoside analog that primarily targets dihydroorotase, exhibiting an inhibition constant (Ki) of 340 µM. This compound has been shown to notably enhance the cytotoxic effects of gamma irradiation. Its applications in research extend to investigating herpes simplex virus type 1 (HSV-1) infection and leukemia, providing valuable insights into therapeutic mechanisms and potential treatment strategies. -
Nucleoside
L-Guanosine is a purine nucleoside that primarily targets nucleoside metabolism. It exhibits anti-herpesvirus activity, making it a valuable tool for studying viral infections. Additionally, L-Guanosine can be utilized in the preparation of supramolecular hydrogels, which have potential applications in drug delivery and tissue engineering. -
Uridine Analog
N3-Methyl-2’-O-methyluridine is a uridine analog that targets diverse biological processes. It has been investigated for its potential anticonvulsant and anxiolytic effects, contributing to research in neurological disorders. Additionally, this compound is valuable in the exploration of new antihypertensive agents, making it a versatile tool in chemical research. -
Purine Nucleoside Analog
2’-Chloro-N6-(3-methoxy)benzyl adenosine is a purine nucleoside analog that exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound demonstrates significant biological activity against indolent lymphoid malignancies, making it a valuable tool in cancer research. Its mechanisms of action are beneficial for studies focusing on therapeutic strategies for various malignancies. -
Purine Nucleoside Analog
Adenosine-2-carboxamide is a purine nucleoside analog that primarily targets cellular proliferation pathways. It exhibits significant antitumor activity against indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable research tool for investigating cancer treatment strategies and understanding purine metabolism in cancer cells. -
Uridine Analog
6-Methyluridine is a uridine analogue that serves as an important tool in neurological research. Its structure allows for the exploration of potential antiepileptic effects, making it useful in studies focused on anticonvulsant and anxiolytic activities. Additionally, this compound may assist in the development of novel antihypertensive agents, contributing to advancements in treatments for hypertension. -
Wobble Modification in tRNA
Mnm5s2U is a wobble modification present in the anticodon of lysine and glutamate tRNAs. This compound plays a crucial role in stabilizing codon-anticodon pairing, thereby enhancing translation fidelity and efficiency. Mnm5s2U is essential for studying tRNA modifications and their impact on protein synthesis, making it a valuable reagent for research in molecular biology and genetics.
