FORX-428 is a selective and orally bioavailable inhibitor of Poly (ADP-ribose) glycohydrolase (PARG), which targets the catalytic domain of human PARG to effectively inhibit its enzymatic activity. By promoting the accumulation of PAR chains, FORX-428 activates DNA damage response pathways and replication stress responses. This compound demonstrates selective antiproliferative effects across a range of cancer cell lines, including those derived from breast, ovarian, and gastric cancers, making it a valuable tool for cancer research and therapeutic studies.
FORX-428 is a selective and orally bioavailable inhibitor of Poly (ADP-ribose) glycohydrolase (PARG), which targets the catalytic domain of human PARG to effectively inhibit its enzymatic activity. By promoting the accumulation of PAR chains, FORX-428 activates DNA damage response pathways and replication stress responses. This compound demonstrates selective antiproliferative effects across a range of cancer cell lines, including those derived from breast, ovarian, and gastric cancers, making it a valuable tool for cancer research and therapeutic studies.
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