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Biological Activity
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.16 mL | 75.78 mL | 151.55 mL |
| 0.5 mM | 3.03 mL | 15.16 mL | 30.31 mL |
| 1 mM | 1.52 mL | 7.58 mL | 15.16 mL |
| 5 mM | 0.3 mL | 1.52 mL | 3.03 mL |
*The above data is based on the productmolecular weight 659.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21511 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 958002-33-0 |
| Formula | C36H45N5O5S |
| M. Wt | 659.84 |
| Purity | >98% |
| Synonyms | BMS-791325, BMS791325, BMS 791325 |
| SMILES | O=C(N1C2CCC1CN(C)C2)[[email protected]@]3(CN4C5=C(C6CCCCC6)C7=CC=C(C(NS(N(C)C)(=O)=O)=O)C=C47)[[email protected]](C8=CC(OC)=CC=C85)C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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