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Catalog No.
Product Name
Application
Product Information
Citations
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RNA Modifying Substance
N4-Acetylcytidine is an RNA-modifying nucleoside metabolite produced during tRNA degradation, primarily via N-acetyltransferase 10 and additional enzymes. This compound has been shown to enhance NLRP3 inflammasome activation through the upregulation and release of HMGB1. N4-Acetylcytidine plays a crucial role in modifying the stability and translation efficiency of mRNA, tRNA, and rRNA, particularly in relation to enterovirus 71 RNA. Its applications extend to research in cancer, neuroinflammatory diseases, viral infections, and obesity. -
Antiviral Agent
Brilliant Black BN is an azo dye with a notable application as an antiviral agent. It effectively inhibits the interaction between enterovirus 71 (EV71) and its uncoating factor, cyclophilin A, demonstrating significant potential in the treatment of viral infections. This compound serves as a valuable tool for research focused on antiviral mechanisms and infectious disease studies. -
enteroviral capsid binder (CB)
Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). - Lanatoside C is an anticancer agent, acting through protein kinase C-delta (PKCdelta) to cause apoptosis of human hepatocellular carcinoma cells.
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EV capsid inhibitor
Pocapavir is an investigational enterovirus (EV) capsid inhibitor. -
capsid inhibitor
Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM. -
antiviral agent
cis-Resveratrol exhibits signifcant antiviral activity. cis-Resveratrol inhibits enteroviruses with IC50s of 12.2 ?M and 37.6 ?M for coxsackievirus B3 (CVB3) and enterovirus 71 (EV71), respectively. -
EV71 Inhibitor
Mosloflavone is a flavonoid derived from Scutellaria baicalensis Georgi, exhibiting inhibitory activity against Enterovirus 71 (EV71). It targets the VP2 protein, preventing viral replication and inhibiting the synthesis of viral capsid proteins during the early stages of infection. Additionally, Mosloflavone demonstrates biocidal properties by inhibiting Pseudomonas aeruginosa virulence and biofilm formation, making it a valuable tool for research in virology and microbiology. -
Dyrk1A Inhibitor
Dyrk1A-IN-12 is a selective inhibitor of Dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A), demonstrating an IC50 of 95 nM. This compound exhibits significant anti-Enterovirus A71 (EV-A71) activity, with an EC50 of 4.4 μM and a cytotoxicity CC50 of 12.8 μM, resulting in a selectivity index of 2.9. Additionally, Dyrk1A-IN-12 shows strong inhibitory effects against herpes simplex virus (HSV), positioning it as a valuable tool for research in viral infections and Dyrk1A-related pathways. -
HCV Inhibitor
TTP-8307 is a potent HCV inhibitor that disrupts the replication of various rhino- and enteroviruses. It specifically inhibits coxsackievirus B3 (CVB3) with an EC50 value of 1.2 μM, alongside poliovirus, by interfering with viral RNA synthesis. The compound exerts its antiviral effects through interaction with oxysterol-binding protein (OSBP), making it a valuable tool for research in virology and antiviral drug development. -
HEVA71/PTP1B Inhibitor
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71) and demonstrates strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 5.5 μM. This compound has significant potential for research applications in virology and metabolic disease studies, particularly in elucidating the roles of HEVA71 and PTP1B in cellular signaling pathways and disease mechanisms. -
EV71 3D Polymerase Inhibitor
DTriP-22 is a potent inhibitor of the enterovirus 71 (EV71) 3D polymerase, characterized by low toxicity. It demonstrates broad-spectrum antiviral activity against RNA viruses, particularly within the picornavirus family, while exhibiting no effects on DNA viruses. By targeting and inhibiting viral RNA synthesis during the early stages of replication, DTriP-22 serves as a valuable reagent in anti-enterovirus research applications. -
RSV RdRp Inhibitor
GS-646089 is a potent inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp). This broad-spectrum antiviral nucleoside analog demonstrates robust activity against RSV, human metapneumovirus (hMPV), rhinovirus, and enteroviruses, with an IC50 in the range of 43 to 46 nM. GS-646089 is converted intracellularly into a triphosphate metabolite that competes with ATP for incorporation into growing RNA chains, effectively terminating viral replication. This compound serves as a valuable tool for research into acute respiratory viral infections and related viral pathogens. -
Antiviral Agent
Phenosulfazole functions as an antiviral agent, demonstrating activity against the poliomyelitis virus. This compound is of significant interest for research applications focusing on viral inhibition and pathogenesis studies related to enteroviruses. Its properties make it a valuable tool for investigations into antiviral mechanisms and therapeutic development. -
Virus Protease Inhibitor
AG-7404 is an orally active, irreversible inhibitor of the picornavirus 3C protease, which disrupts the processing of viral polyproteins and effectively inhibits viral replication. This compound demonstrates synergistic antiviral activity when used alongside capsid inhibitors, making it valuable for research on enterovirus infections, including poliovirus. AG-7404 is particularly useful in studies involving V-073-resistant viral variants, contributing to a deeper understanding of antiviral mechanisms and potential therapies. -
EV71 Inhibitor
Gylongiposide I is a selective inhibitor targeting enterovirus EV71, demonstrating an EC50 of 1.53 μM. It exerts antiviral activity by decreasing the expression of viral protein VP1 and reducing levels of viral genomic RNA. This compound is valuable for research and development of therapeutic agents aimed at combating hand, foot, and mouth disease associated with EV71. -
Antirhinovirus Compound
MDL-20610 is a potent antirhinovirus compound that exhibits a median plaque 50% inhibitory concentration (IC50) of 0.003 µg/mL. This compound also demonstrates antiviral activity against human, simian, and bovine rotaviruses, along with variable effectiveness against enteroviruses and paramyxoviruses. MDL-20610 is valuable for antiviral research applications, particularly in the study of viral infections and therapeutic interventions. -
Enteroviral Capsid Binder
Vapendavir diphosphate is a potent enteroviral capsid binder that exhibits significant antiviral activity against enterovirus 71 (EV71). With effective concentrations (EC50) ranging from 0.5 to 1.4 μM across various EV71 strains, it serves as a valuable tool for research focused on enteroviral pathogenesis and therapeutic development. Its ability to inhibit viral replication makes it a critical reagent for studying enteroviral infections and potential antiviral strategies. -
Enterovirus 71 Inhibitor
Norwogonin is an antiviral compound isolated from Scutellaria baicalensis Georgi that specifically targets Enterovirus 71 (EV71). It demonstrates a potent inhibitory effect, with an IC50 value of 31.83 μg/ml, making it a valuable tool for research in viral infection mechanisms and potential therapeutic strategies against EV71. This compound can contribute to studies focused on antiviral drug development and the exploration of natural product-derived therapeutics. -
EV71 Inhibitor
DMA-135 hydrochloride is a specific inhibitor of enterovirus 71 (EV71) that targets the IRES-dependent translation and replication pathways. It binds to the EV71 SLII domain with a moderately high affinity (KD = 520 nM), effectively suppressing viral activity. This compound exhibits minimal toxicity in cell-based studies, making it an important tool for research in virology and potential therapeutic applications against EV71 infections. -
Anti-virus Agent
2-Hydroxytetradecanoic acid is a hydroxy fatty acid that functions as an antiviral agent by inhibiting the cleavage between enterovirus capsid proteins VP4 and VP2. This compound exhibits significant antiviral activity, making it a valuable tool for research applications focused on viral infection mechanisms and the development of antiviral therapies. -
Antiviral Agent
Enviroxime (LY122772) is an antiviral agent that disrupts the replication of rhinoviruses and enteroviruses. By targeting the viral 3A coding region, Enviroxime effectively inhibits the synthesis of plus-strand viral RNA. This compound serves as a valuable tool for researchers studying the functional role of the 3A protein in viral pathogenesis and replication processes. -
Biochemical Assay Reagent
N-Phenylbenzamide is a biochemical assay reagent that functions primarily as a compound skeleton for various research applications. It demonstrates significant biological activity in studies related to cancer and infectious diseases, including enterovirus and cervical cancer. This compound is essential for exploring the underlying mechanisms of these conditions and developing potential therapeutic strategies. -
Antipicornavirus Agent
WIN 54954 functions as an orally active, broad-spectrum antipicornavirus agent, targeting various strains of picornaviruses. It demonstrates significant efficacy against human rhinovirus, echovirus 9, and enterovirus infections. This compound is valuable for research on viral pathogenesis and the development of therapeutic strategies against picornavirus-related diseases. -
Monoamine Oxidase Inhibitor
Pirlindole is a selective and reversible inhibitor of monoamine oxidase A (MAO-A). This compound exhibits significant antiviral activity against enterovirus-D68 and coxsackievirus B3 (CV-B3). Pirlindole is primarily utilized in research focusing on the modulation of monoamine levels and the investigation of viral pathologies. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
EV71 3C Protease Inhibitor
DC07090 dihydrochloride is a potent, reversible, and competitive inhibitor of the human enterovirus 71 (EV71) 3C protease. It exhibits low toxicity with an IC50 of 21.72 μM and a Ki value of 23.29 μM. Additionally, DC07090 dihydrochloride effectively inhibits coxsackievirus A16 (CVA16) replication, with an EC50 of 27.76 μM. This compound is valuable for research into enteroviral infections and potential therapeutic interventions against these viruses. -
Stable Isotope
Vapendavir-d5 is a deuterium-labeled derivative of Vapendavir, a potent enteroviral capsid binder. This stable isotope is utilized in research to study the mechanisms of action against enterovirus 71 (EV71), exhibiting significant antiviral activity with EC50 values ranging from 0.5 to 1.4 μM across various EV71 strains. Vapendavir-d5 serves as a valuable tool in understanding enteroviral infections and developing therapeutic strategies. -
EV71 Inhibitor
Methyl 3,4-dihydroxyphenylacetate is a potent inhibitor of enterovirus 71 (EV71) replication. This compound effectively reduces viral replication in rhabdomyosarcoma (RD) cells, highlighting its potential as an antiviral agent. Its biological activity makes it valuable for research into therapeutic strategies against EV71 and other enteroviral infections. -
Antiviral Agent
Antiviral Agent 24 is a potent antiviral compound that primarily targets viral replication pathways. Exhibiting EC50 values of 0.101 µM for Enterovirus 71 (EV71), 19.9 µM for Coxsackievirus A21 (CVA21), and 91.2 µM for Enterovirus 68 (EV68), this reagent demonstrates significant antiviral activity. Additionally, Antiviral Agent 24 inhibits the enzymatic activity of METTL3/METTL14 in a dose-dependent manner, showcasing its potential utility in antiviral research applications. -
Polioviruses Inhibitor
Disoxaril is a potent inhibitor of polioviruses, effectively impeding the replication of types 1 and 2 within host cells. It operates by binding to virion capsid proteins, facilitating viral uncoating stabilization, while still permitting virus entry through receptor-mediated endocytosis. Additionally, Disoxaril demonstrates inhibitory activity against enterovirus replication, making it a valuable reagent for virology research and studies on enterovirus-related diseases. -
Antienterovirus Agent
AN-12-H5 is an antienterovirus agent that specifically targets the replication processes of poliovirus (PV) and enterovirus 71 (EV71). This compound exhibits significant antiviral activity, making it a valuable tool for research into enteroviral infections and their mechanisms. Its ability to inhibit viral replication positions AN-12-H5 as a promising candidate for studies aimed at developing therapeutic strategies against enterovirus-related diseases. -
Antiviral Drug
BTA-188 is a pyridazinyl oxime ether that functions as a potent antiviral agent, specifically targeting rhinoviruses and enterovirus 71. It demonstrates remarkable efficacy with an IC50 of 0.8 nM and IC90 of 11 nM against HRV-2, while effectively inhibiting enterovirus replication with an IC50 of 82 nM and an IC90 of 109 nM. BTA-188 holds potential as a chemotherapeutic candidate for treating infections associated with the Picornaviridae family of viruses. -
Enterovirus Inhibitor
Antiviral agent 23 is a potent inhibitor of enterovirus 71 (EV71) with an EC50 value of 94 nM. It effectively suppresses the activity of the methyltransferase complex METTL3/METTL14, demonstrating significant antiviral activity. This compound is suitable for research focused on enteroviral infections and the mechanisms of RNA modification in viral pathogenesis. -
HIV/EV-A71 Inhibitor
AL-470 is a potent antiviral compound targeting HIV-1, HIV-2, and EV-A71, exhibiting EC50 values of 0.27 µM, 0.63 µM, and 0.35 µM, respectively. This compound demonstrates significant inhibition of viral replication and is suitable for studies focused on HIV and enterovirus A71 infections. AL-470 serves as a valuable tool for researchers investigating antiviral mechanisms and therapeutic strategies against these viral pathogens. -
Stable Isotope
Pleconaril-d4 is a deuterated analog of Pleconaril, designed as a stable isotope for advanced chemical research. This labeled compound serves as a valuable tool for tracing and quantifying Pleconaril-related metabolic pathways and interactions. Its use in studies involving viral infections, particularly enteroviruses, enhances understanding of drug efficacy and pharmacokinetics in biological systems. -
Antiviral Agent
JX040 is an antiviral agent that demonstrates significant activity against non-polio enteroviruses, while exhibiting weaker efficacy against polioviruses. This compound is valuable for research applications focusing on enteroviral infections, potentially aiding in the development of therapeutic interventions for these viral diseases. -
Enterovirus Antiviral Agent
Viral 2C Protein Inhibitor 1 is a potent enterovirus antiviral agent that targets the viral 2C protein, effectively inhibiting various strains, including EV-D68, EV-A71, and CVB3. With EC50 values ranging from 0.1 to 3.6 µM, this compound demonstrates a high selectivity index and low cytotoxicity, making it a valuable tool for research into enterovirus-related diseases and potential therapeutic applications. -
Enteroviru Inhibitor
R78206 is an antiviral pyridazinamine compound that targets enteroviruses by providing protection against thermal inactivation. This compound exhibits varied effects on different strains of poliovirus depending on concentration and demonstrates a potent stabilizing effect on Mahoney procapsids. R78206 is valuable for research applications focused on enteroviral pathogenesis and potential therapeutic interventions. -
EV71 3C Protease Inhibitor
DC07090 is a potent, reversible, and competitive inhibitor of the human enterovirus 71 (EV71) 3C protease, with an IC50 of 21.72 μM and a Ki value of 23.29 μM. This compound also demonstrates inhibitory activity against coxsackievirus A16 (CVA16) replication, exhibiting an EC50 value of 27.76 μM. DC07090 is valuable for research applications focused on the development of antiviral strategies targeting enteroviruses. -
Golgicide A Racemate
(Rac)-Golgicide A is a racemic mixture of the potent and selective inhibitor Golgicide A, targeting the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factor GBF1. This compound exhibits significant inhibitory activity against coxsackievirus B3 and other enteroviruses, making it a valuable tool for studying viral replication mechanisms. Its reversible nature allows for detailed exploration of cellular processes associated with Golgi function and virus-host interactions in research applications. -
EV-A71 Inhibitor
EV-A71-IN-1 is an inhibitor targeting the human enterovirus A71 (EV-A71) capsid protein, exhibiting an EC50 of 0.27 μM. This compound functions as a capsid binder, effectively interfering with the interaction between the viral VP1 protein and the host receptor hSCARB2. Additionally, EV-A71-IN-1 demonstrates broad inhibitory activity against various human enteroviruses while maintaining low cytotoxicity (CC50 > 56.2 μM), making it a valuable tool for research on enteroviral infections and potential therapeutic interventions. -
MAO-A Inhibitor
Pirlindole mesylate is a selective and reversible inhibitor of monoamine oxidase A (MAO-A), playing a crucial role in the modulation of neurotransmitter metabolism. Additionally, Pirlindole exhibits antiviral activity against enterovirus D68 and coxsackievirus B3 (CV-B3), positioning it as a potential agent in virology research. This compound is valuable for studies focusing on depression, anxiety disorders, and the therapeutic mechanisms of neuronal regulation and viral infections. -
Anti-EV71 Agent
Antiviral Agent 21 exhibits potent activity against Enterovirus 71 (EV71), targeting viral replication mechanisms. This compound effectively inhibits the proliferation of EV71, making it a valuable tool for research into antiviral therapies and the mechanism of viral infection. Its application is particularly relevant for studies focusing on neurotropic viruses and associated diseases, facilitating the development of therapeutic interventions. -
ROC/EV-A71 Inhibitor
Fukinolic acid serves as a receptor-operated Ca2+ channel (ROC) inhibitor, effectively suppressing extracellular Ca2+ influx activated by norepinephrine while preserving the function of voltage-dependent Ca2+ channels. This compound demonstrates notable antiviral activity against enterovirus A71 (EV-A71) replication, making it a valuable tool in research related to enteroviral infections. Additionally, its vasodilatory properties further enhance its potential applications in cardiovascular studies. -
Enteroviruses Replication Inhibitor
MRL-1237 is an enterovirus replication inhibitor that targets the non-structural protein 2C. It demonstrates effective inhibition of poliovirus and other enteroviruses, making it a valuable tool for studying viral infections. Notably, MRL-1237 does not interfere with the NTPase (ATPase) activity of the 2C protein, allowing for specific mechanistic investigations in enteroviral research applications. -
EVs 2C Inhibitor
Jun15716 is an inhibitor of the Enterovirus (EVs) 2C protein, exhibiting dissociation constants (Kis) of 15.9, 44.2, and 17.8 μM for EV-D68, EV-A71, and CVB3, respectively. This compound demonstrates significant antiviral activity, with effective concentrations (EC50) of 1.0 μM against EV-D68 and 0.7 μM against CVB3 in relevant cellular models. Jun15716 is applicable in virology research, particularly in studies related to viral infections such as meningitis, hand, foot and mouth disease (HFMD), and viral myocarditis. -
2C Inhibitor
R523062 is a viral 2C inhibitor that targets the 2C protein of enteroviruses. This compound effectively reduces the levels of the viral VP1 protein, thereby impairing viral replication. R523062 exhibits broad-spectrum antiviral activity against enterovirus D68 (EV-D68) strains, making it a valuable tool for research in antiviral therapeutics and virology. -
CV-B3 2C ATPase Inhibitor
ATPase-IN-8 is a selective inhibitor of CV-B3 2C ATPase, exhibiting an IC50 of 1.4 μM. This compound demonstrates significant anti-enteroviral activity, particularly against coxsackievirus B3 (CV-B3) and enterovirus D68 (EV-D68). ATPase-IN-8 is suitable for research applications focusing on enteroviral infections and their molecular mechanisms. -
EV71 Inhibitor
ZHSI-1 is a potent inhibitor of Enterovirus 71 (EV71), targeting viral replication and mitigating virus-induced pyroptosis linked to pathogenesis. This compound effectively prevents EV71 infection in neonatal and young murine models, making it a valuable tool for research in viral infections, specifically related to hand, foot, and mouth disease (HFMD). Its application may contribute to the understanding of EV71 behavior and aid in developing therapeutic strategies against this virus.
