Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Anti-inflammatory Agent 22 is an orally active compound targeting the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production, demonstrated by an IC50 of 14.6 μM. This agent exhibits preventive effects on lymphedematous tissue by suppressing adipogenesis. Additionally, Anti-inflammatory Agent 22 has been shown to reduce limb lymphedema volume in murine models, making it a valuable tool for research into inflammatory conditions and lymphedema management. -
Anti-inflammatory Agent
Anti-inflammatory Agent 15 is a potent compound targeting inflammation through inhibition of nitric oxide synthase (iNOS). It demonstrates significant antimycobacterial activity against Mycobacterium tuberculosis strains H37Rv and M299, with MIC50 values of 2.3 μM and 7.8 μM, respectively. This agent effectively reduces pro-inflammatory cytokines TNF-α and IL-1β, making it a valuable tool for researching tuberculosis and related inflammatory pathways. -
Anti-inflammatory Agent
3-O-Caffeoyl-5-O-feruloylquinic acid is a phenolic compound with potent anti-inflammatory properties, primarily targeting free radical scavenging mechanisms. It effectively regulates inflammatory pathways by inhibiting TNF-α-induced production of reactive oxygen species (ROS) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs). This compound is valuable in research applications focused on oxidative stress and inflammation pathways, offering insights into potential therapeutic strategies for inflammatory disorders. -
Anti-inflammatory Agent
Anti-inflammatory agent 104 is a potent anti-inflammatory compound that specifically inhibits TNF-α synthesis and release in the human macrophage cell line U937, with an IC50 value of 0.024 nM. This agent demonstrates significant biological activity by reducing eosinophil levels in rat lungs by 63%, making it a valuable tool for studying inflammatory responses and evaluating therapeutic strategies in related research applications. -
Anti-inflammatory Agent
Anti-inflammatory Agent 55 is a derivative of Coixol that primarily inhibits the NF-κB signaling pathway. It effectively reduces the expression of pro-inflammatory markers such as iNOS, TNF-α, IL-6, and IL-1β. This compound significantly decreases LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 value of 0.8 μM and demonstrates noteworthy in vivo anti-inflammatory effects in a mouse auricular edema model, making it a valuable tool for research in inflammation and immune responses. -
Anti-inflammatory Agent
Siaresinolic acid is an anti-inflammatory compound derived from the leaves of Sabicea grisea. It exhibits significant antinociceptive properties by modulating ATP-dependent potassium channels and inhibiting the influx of leukocytes, plasma leakage, and the production of pro-inflammatory mediators such as TNF-α and IL-1β. Importantly, Siaresinolic acid demonstrates a lack of cytotoxicity in murine macrophages and does not affect locomotor activity even at elevated doses. This compound is suitable for research applications involving pleurisy and pain management. -
Anti-inflammatory agent
Taxamairin B is a potent anti-inflammatory agent that targets proinflammatory cytokine production. It effectively reduces the expression of TNF-α, IL-1β, and IL-6, as well as the oxidative stress markers nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW264.7 macrophage cells. Additionally, Taxamairin B demonstrates significant protective effects in models of LPS-induced acute lung injury in mice, making it a valuable compound for research on inflammatory pathways and potential therapeutic applications. -
Anti-inflammatory Agent
Oleracone is an alkaloid derived from Portulaca oleracea L. that functions as an anti-inflammatory agent. It demonstrates potent anti-inflammatory effects in the RAW 264.7 macrophage model, effectively inhibiting nitric oxide production and reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone is suitable for researching inflammatory diseases and exploring potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 54, a derivative of Coixol, targets the NF-κB signaling pathway to exert its anti-inflammatory effects. This compound effectively downregulates pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β. Notably, anti-inflammatory agent 54 inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates significant in vivo anti-inflammatory activity in a mouse model of auricular edema. -
Proinflammatory Cytokine Inhibitor
Semapimod is a potent inhibitor of proinflammatory cytokine production, targeting Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM. It effectively inhibits the production of key cytokines such as TNF-α, IL-1β, and IL-6, as well as p38 MAPK activity and nitric oxide production in macrophages. This compound holds promise for research in various inflammatory and autoimmune disorders. -
Antioxidant/Anti-inflammatory/Anti-fibrotic Agent
7-O-Galloyl-D-sedoheptulose is a polyphenolic compound recognized for its antioxidant, anti-inflammatory, and anti-fibrotic properties. It lowers serum levels of glucose, leptin, insulin, and pro-inflammatory cytokines such as TNF-α and IL-6, while increasing adiponectin levels. This compound effectively reduces reactive oxygen species (ROS) and lipid peroxidation by inhibiting the expression of NADPH oxidase components. Additionally, it down-regulates NF-κB signaling and relevant fibrotic markers, highlighting its potential applications in studying type 2 diabetes and associated complications in hepatic and pancreatic tissues. -
Anti-inflammatory Agents
CZEN-002 is a derivative of alpha-melanocyte-stimulating hormone that acts as an anti-inflammatory agent by inhibiting the production of TNF-α. It exhibits both anti-inflammatory and antibacterial properties, making it a valuable tool for researching inflammatory diseases and potential therapeutic interventions. Its mechanism of action opens avenues for studies related to immune response modulation and pathogen resistance. -
Anti-inflammatory Agent
HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 17 is a potent orally active compound that targets inflammatory pathways by inhibiting the release of pro-inflammatory cytokines IL-6 and TNF-α. In vitro studies demonstrate its ability to reduce inflammation without inducing cytotoxicity. Additionally, anti-inflammatory agent 17 exhibits significant anti-inflammatory activity in vivo, making it a valuable tool for research into acute lung injury (ALI) and other inflammatory conditions. -
Anti-inflammatory Agent
CX-659S is an orally active 5-carboxamide uracil derivative with anti-inflammatory properties. It effectively inhibits lipid peroxidation with an IC50 of 5.9 μM and reduces the infiltration of neutrophils and eosinophils. CX-659S also inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α, making it a valuable tool for research on inflammatory conditions. -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research. -
Anti-inflammatory Agent
Desoxo-narchinol A is a potent anti-inflammatory agent that is derived from the roots and rhizomes of Nardostachys jatamansi. This compound exhibits significant biological activity, making it a valuable tool for research into septic shock and various inflammatory diseases. Its oral activity further enhances its applicability in preclinical studies, providing insight into therapeutic strategies for managing inflammation-related conditions. -
Anti-inflammatory Analgesic/Anti-tumor/Diuretic Agent
Hecogenin acetate is an orally active steroid saponin aglycone that functions primarily as an anti-inflammatory and analgesic agent. It exerts its biological effects by inhibiting the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizing TRPA1/TRPM8 channels, and reducing the production of pro-inflammatory cytokines. Additionally, Hecogenin acetate demonstrates neuroprotective and anti-tumor properties, inhibits reactive oxygen species (ROS) production, and downregulates MMP-2 expression. This compound also enhances gastric mucosal defense and promotes ulcer healing while potentially restoring antibiotic sensitivity when used in combination with specific antibiotics. -
Anti-inflammatory Agent
Shizukaol B is an anti-inflammatory agent derived from the lindenane-type dimeric sesquiterpene found in Chloranthus henryi. This compound demonstrates significant inhibitory effects against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells, effectively reducing nitric oxide production and downregulating the expression of pro-inflammatory markers such as iNOS, COX-2, TNF-α, and IL-1β. Shizukaol B is suitable for research applications focused on neuroinflammation and related therapeutic strategies. -
Anti-inflammatory Agent
Chloranthalactone B is a lindenane-type sesquiterpenoid that functions as an anti-inflammatory agent. Isolated from the Chinese medicinal herb Sarcandra glabra, this compound effectively inhibits the production of inflammatory mediators by targeting the AP-1 and p38 MAPK signaling pathways. Its role in modulating inflammation makes it a valuable tool for research in inflammation-related studies and therapeutic applications. -
Anti-neuroinflammatory Agent
Grossamide is a natural compound extracted from the dried fruit of Cannabis sativa L. Its primary mechanism involves anti-neuroinflammatory activity, making it a valuable agent for research into neuroinflammatory conditions. Grossamide has potential applications in studies focused on neuroprotection and inflammation-related pathways in the nervous system. -
Anti-inflammatory Agent
EM-163 is an anti-inflammatory agent that selectively targets the TIR domain of MyD88. By intervening in the inflammatory signaling pathways, EM-163 has demonstrated efficacy in alleviating inflammation and protecting against toxic shock. This compound is particularly relevant for research related to Staphylococcal enterotoxin B (SEB) poisoning, providing a valuable tool for investigators studying inflammatory responses and potential therapeutic interventions. -
Anti-Inflammatory Agent
Skimmin, a glucoside of umbelliferone, is primarily recognized for its anti-inflammatory properties. Extracted from Hydrangea paniculata, this compound exhibits renal protective effects by enhancing creatinine clearance and mitigating kidney injury. Additionally, Skimmin demonstrates significant anti-amoebic activity against Entamoeba histolytica, as well as anti-cancer and neuroprotective effects. Its influence on cardiac health is evident through the reduction of fibrosis and the modulation of inflammatory cytokines, including TNF-α and IL-6. Skimmin serves as a valuable research tool in the study of diabetes and associated metabolic disorders. -
Anti-inflammatory Agent
1,4-Dicaffeoylquinic acid is a phenylpropanoid compound that functions as an anti-inflammatory agent through the inhibition of xanthine oxidase, with an IC50 of 7.36 μM. This compound effectively reduces inflammation by inhibiting the production of TNF-α induced by lipopolysaccharides (LPS). Its role in modulating inflammatory responses makes 1,4-Dicaffeoylquinic acid a valuable tool for research in inflammation-related studies. -
Anti-inflammatory Agent
9-Methoxycanthin-6-one, an alkaloid derived from canthin-6-one, acts as an anti-inflammatory agent. This compound demonstrates notable anti-tumor activity and effectively inhibits LPS-induced production of pro-inflammatory cytokines such as TNF-α and IL-1β. It is utilized in research applications focused on inflammation and tumor biology. -
Anti-inflammatory Agents
(±)-Perillaldehyde is an anti-inflammatory agent that demonstrates significant biological activity by inducing JNK activation in RAW264.7 cells. This compound inhibits the expression of TNF-α, with an IC50 value of 171.7 μM, highlighting its potential in modulating inflammatory responses. Additionally, (±)-Perillaldehyde exhibits antidepressant effects through its action on the olfactory nervous system, making it relevant for research into stress-related disorders. -
Anti-inflammatory Agent
7,3',4'-Tri-O-methylluteolin is a flavonoid that acts as an anti-inflammatory agent by inhibiting soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. This compound demonstrates significant anti-inflammatory effects in LPS-induced RAW 264.7 macrophages and has been shown to inhibit the MDM2-p53 binding, thereby inducing apoptosis in MCF-7 breast cancer cells. Furthermore, 7,3',4'-Tri-O-methylluteolin exhibits antioxidant, antifungal, and antitrypanosomal properties, making it valuable for various biological research applications. -
Anti-inflammatory Agent
Episappanol is a natural compound derived from the heartwood of Caesalpinia sappan, functioning primarily as an anti-inflammatory agent. It effectively inhibits the secretion of pro-inflammatory cytokines, including IL-6 and TNF-α. This compound is valuable for research applications aimed at exploring inflammation-related pathways and potential therapeutic interventions for inflammatory diseases. -
Anti-Inflammatory Agent
Kaempferol 3-O-sophoroside is an anti-inflammatory agent that functions primarily by inhibiting the toll-like receptors TLR2 and TLR4 associated with High mobility group box 1 (HMGB1). This compound displays notable anti-inflammatory and analgesic properties, primarily through the inhibition of NF-κB activation and the subsequent reduction of TNF-α production. Additionally, it promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances autophagy via AMP-activated protein kinase (AMPK) activation, contributing to its antidepressant effects. Kaempferol 3-O-sophoroside is a valuable tool for research focused on inflammation and neurodegenerative diseases. -
Anti-inflammatory Agent
Edpetiline is an anti-inflammatory agent that targets the inhibition of IκB phosphorylation, thereby preventing the nuclear translocation of NF-κB p65. This compound also inhibits p38 MAPK and ERK MAPK phosphorylation, leading to reduced intracellular ROS levels. Furthermore, Edpetiline downregulates pro-inflammatory cytokines such as TNF-α, IL-6, iNOS, and COX-2 while promoting the expression of the anti-inflammatory cytokine IL-4. It is suitable for research into conditions related to inflammation and oxidative stress. -
Anti-inflammatory Agent
Taurohyodeoxycholic acid sodium is the taurine-conjugated derivative of hyodeoxycholic acid, serving as an anti-inflammatory agent. It effectively reduces the activity and expression of myeloperoxidase, TNF-α, and IL-6, demonstrating protective effects against colonic damage in TNBS-induced ulcerative colitis models. This compound is valuable for researchers investigating inflammatory pathways and therapeutic strategies in gastrointestinal disorders. -
Proinflammatory Cytokine Inhibitor
Semapimod tetrahydrochloride is a potent inhibitor of proinflammatory cytokine production, specifically targeting tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). This compound effectively disrupts Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM, thereby inhibiting p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride holds promise for the treatment of various inflammatory and autoimmune disorders through its modulatory effects on immune responses. -
Anti-inflammatory agent
DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is an organic compound known for its anti-inflammatory properties. It exhibits protective effects on intestinal epithelial cells, making it valuable for research related to inflammation and gut health. This reagent is useful in studying the pathways involved in inflammatory responses and exploring therapeutic solutions for inflammatory disorders. -
Anti-inflammatory Agent
Lupeol acetate is a derivative of Lupeol that functions as an anti-inflammatory agent. It exhibits significant biological activity by down-regulating the expression of inflammatory cytokines and inhibiting osteoclast production, thereby improving symptoms of rheumatoid arthritis. Additionally, Lupeol acetate shows antibacterial and anti-trypanosomic properties and has been observed to inhibit spermatogenesis in male rats, potentially leading to infertility. This compound is suitable for research applications related to inflammation, cancer, and reproductive health. -
Anti-inflammatory Agent
β-Amyrin acetate is a triterpenoid recognized for its anti-inflammatory properties. This compound exhibits a range of biological activities, including antifungal, anti-diabetic, and anti-hyperlipidemic effects. Research indicates that β-Amyrin acetate can inhibit HMG-CoA reductase activity by binding to the hydrophobic cleft of the enzyme, making it a valuable candidate for studies related to lipid metabolism and inflammation management. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
Anti-inflammatory
(2R)-Octyl-α-hydroxyglutarate sodium is the sodium salt derivative of (2R)-Octyl-α-hydroxyglutarate, functioning primarily as an anti-inflammatory agent. This compound demonstrates significant biological activity in modulating inflammatory responses, making it valuable in various research applications focused on inflammation and related pathways. -
Anti-inflammatory Agent
NPB-1575 is a potent, orally bioavailable anti-inflammatory agent that effectively targets neuroinflammation. It functions by activating the IRS2/Nrf2/NF-κB signaling axis, thereby combating ferroptosis and providing neuroprotection. NPB-1575 demonstrates efficacy in mitigating cerebral ischemic injury and enhancing neurological outcomes, making it a valuable tool for research focused on ischemic stroke and related neurodegenerative conditions. -
Anti-inflammatory Agent
Ligustrazine, an alkylpyrazine derived from Ligusticum chuanxiong, functions primarily as an anti-inflammatory agent. This compound has demonstrated notable anti-inflammatory and potential nootropic activities in preclinical studies with rat models. It is utilized in research focused on inflammatory pathways and cognitive enhancement, providing valuable insights into therapeutic applications in neuroprotection and inflammation modulation. -
Anti-inflammatory Agent
Lutein, a xanthophyll carotenoid, acts as a potent anti-inflammatory agent. It demonstrates significant biological activities, including antioxidant and anti-apoptotic effects, primarily by modulating reactive oxygen species (ROS) levels. Lutein is particularly noted for its protective benefits on ocular health and exhibits neuroprotective and antidepressant-like effects in the brain. This compound is biologically active when administered orally, making it a valuable reagent for studies in inflammation and neuroprotection. -
Non-Steroidal Anti-Inflammatory Agent
Glafenine hydrochloride is a non-selective non-steroidal anti-inflammatory agent and a dual inhibitor of COX-1 and COX-2 enzymes. It demonstrates anti-inflammatory, anti-proliferative, and anti-migratory effects by disrupting the arachidonic acid metabolic pathway and decreasing prostaglandin synthesis. This compound induces cell cycle arrest in vascular smooth muscle and endothelial cells, while also lowering Tenascin levels in the extracellular matrix. Glafenine hydrochloride is applicable in the study of inflammatory diseases, vascular restenosis, and cystic fibrosis. -
Anti-Inflammatory Agent
Proanthocyanidins are a class of polyphenolic compounds characterized by their electrophilic flavanyl units, primarily recognized for their anti-inflammatory properties. They exhibit strong antioxidant activity and have been shown to possess anticancer effects, as well as cardioprotective, antibacterial, and antifungal activities. Research applications include their potential use in treating conditions such as chronic venous insufficiency, capillary fragility, sunburn, and retinopathy. -
Anti-inflammatory Agent
Seselin is an anti-inflammatory agent that exerts its effects through multiple biological pathways. It has demonstrated potential in anticancer, antinociceptive, and antifungal activities. Seselin is suitable for research applications focused on inflammation and pain management. Its oral bioavailability enhances its utility in vivo studies. -
Anti-Inflammatory Agent
Nepetoidin B is an anti-inflammatory agent that exerts its effects by modulating the NF-κB and Nrf2/HO-1 signaling pathways. In addition to its anti-inflammatory properties, Nepetoidin B also demonstrates antifungal and antibacterial activities. This natural compound, derived from Salvia plebeia R. Br., is suitable for research applications focused on inflammation and infectious diseases. -
Anti-inflammatory Agent
Myristinin A is a flavan compound that exhibits anti-inflammatory properties by selectively inhibiting COX-2 activity, with an IC50 value of 16.9 μg/mL. It reduces the production of prostaglandin E2 (PGE2) and inhibits phospholipase A2 (PLA2), effectively blocking the release of inflammatory mediators. Additionally, Myristinin A demonstrates antifungal activity against Candida albicans, with an IC50 of 8.8 μg/mL. This compound is valuable for research into inflammation and infection, particularly in conditions such as rheumatoid arthritis. -
Anti-inflammatory/Anti-microbial Agent
Nyasol is a bioactive compound known for its anti-inflammatory and antimicrobial properties. It demonstrates significant antifungal, antibacterial, and antileishmanial activities, alongside hyaluronidase inhibition. Nyasol effectively inhibits the binding of leukotriene B4 (LTB4) to human neutrophils and suppresses neuroinflammatory responses by inhibiting I-κB degradation in lipopolysaccharide-stimulated BV-2 microglial cells. This compound is valuable in research focused on inflammatory diseases and microbial infections. -
Antiinflammatory Agent
Resolvin D3 (RvD3) is a bioactive mediator derived from docosahexaenoic acid (DHA) with potent anti-inflammatory properties. This compound plays a crucial role in resolving inflammation, making it particularly relevant for research into inflammatory conditions such as arthritis. By modulating immune responses, Resolvin D3 facilitates the resolution of inflammation, providing insights into therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Fmoc-Leucine, an anti-inflammatory agent, functions primarily as a selective ligand for PPARγ, with a binding affinity (Ki) of 15 μM. It promotes both extracellular Ca2+ influx and intracellular Ca2+ release while exhibiting insulin-sensitizing effects with minimal fatogenic activity. This compound demonstrates unique self-assembly characteristics, forming transient gels, stable gels, or crystals/2D sheets under varying conditions. Fmoc-Leucine is valuable for research related to diabetes, colitis, and bladder cancer. -
Anti-inflammatory Agent
Hexadecanamide is a fatty acid amide that serves as an anti-inflammatory agent, exhibiting protective effects against Staphylococcus aureus and SARA-induced mastitis. It functions by suppressing S. aureus-mediated NF-κB activation and enhancing blood-milk barrier integrity. Additionally, Hexadecanamide activates PPARα and has been shown to improve sperm motility in vitro. This compound is relevant for research applications involving mastitis and asthenozoospermia. -
Anti-Inflammatory/Cancer Agent
Norathyriol is a natural metabolite derived from Mangifera, exhibiting significant anti-inflammatory and anticancer properties. It functions as a noncompetitive inhibitor of α-glucosidase with an IC50 value of 3.12 μM. Additionally, Norathyriol inhibits the peroxisome proliferator-activated receptors (PPARs) α, β, and γ, with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively. This compound demonstrates a range of biological activities, including antioxidant, antimicrobial, and antibacterial effects, making it valuable for diverse research applications in inflammation and cancer therapeutics.
