Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Oleanolic acid 28-O-β-D-glucopyranoside, a pentacyclic triterpenoid, primarily acts as an anti-inflammatory agent. It has demonstrated the ability to inhibit inflammatory responses in ulcerative colitis models, enhance intestinal epithelial barrier function, and modulate gut microbiota. The compound's mechanism involves the modulation of the PI3K-AKT and MAPK signaling pathways. Oleanolic acid 28-O-β-D-glucopyranoside is valuable for research into inflammatory diseases, particularly colitis. -
Antiinflammatory Agent
Ethyl linoleate, an unsaturated fatty acid derivative, acts as an anti-inflammatory agent by inhibiting the Akt/GSK3β/β-catenin signaling pathway and blocking NF-κB activation. Additionally, it induces heme oxygenase-1 and inhibits tyrosinase, contributing to its whitening and anti-inflammatory properties. Ethyl linoleate promotes absorption of compounds and has notable implications for atherosclerosis research. Its applications extend to the study of various inflammatory diseases and cosmetic formulations. -
Anti-inflammatory Reagent
Syringaresinol is a lignan-type phytochemical that primarily targets anti-inflammatory pathways. It effectively inhibits the NF-κB and AKT signaling pathways in IL-1β-activated mouse chondrocytes, demonstrating significant anti-inflammatory activity. Additionally, Syringaresinol enhances the phosphorylation of AMPK and eNOS while increasing intracellular Ca2+ levels in HUVECs. Its ability to attenuate the progression of osteoarthritis in mouse models of DMM-induced osteoarthritis makes it a valuable reagent for research focused on OA. -
Anti-inflammatory/Oxidant
Astringin is a natural flavonoid compound that primarily targets inflammatory pathways and oxidative stress. It exhibits significant anti-inflammatory, antioxidant, and anti-apoptotic activities, while also functioning as a ferroptosis inhibitor. Research applications include its potential use in studying diseases characterized by oxidative damage and inflammation, such as acute lung injury. -
Anti-inflammatory Agent
Strictosamide is a natural compound isolated from Nauclea officinalis, primarily functioning as an anti-inflammatory agent. It exhibits multiple biological activities, including analgesic properties, anti-Plasmodium effects, antifungal activity, and the promotion of wound healing. This compound is valuable for research in inflammation, pain management, and infectious disease studies. -
Inflammatory Modulator
Cholesta-3,5-diene is an inflammatory modulator that primarily targets immune cells, including neutrophils, to enhance wound healing processes. It facilitates neutrophil chemotaxis and fibroblast migration by activating chemokine receptor-mediated signaling pathways, such as the PI3K/Akt pathway. This compound can be utilized in topical applications for wound repair and exhibits potential therapeutic benefits in managing chronic ulcers and skin lesions. -
Anti-Inflammatory/Immunosuppressive Signal
Phosphatidylserine is a phospholipid that serves as an important anti-inflammatory and immunosuppressive signal. It is known to facilitate membrane translocation and activate protein kinase C, which is integral to Akt signaling through its interaction with PIP3. Additionally, localized exposure to phosphatidylserine promotes microglial phagocytosis, aiding in synaptic refinement, and acts as a pro-coagulant factor in the extracellular space by signaling for the clearance of apoptotic cells. This reagent has significant implications in research focused on inflammation regulation and immune response modulation. -
Anti-inflammatory And Antioxidant
Tamarixetin, a 4'-O-Methyl Quercetin derivative, serves as a potent inhibitor of the caseinolytic protease P (ClpP) and exhibits significant anti-inflammatory and antioxidant properties. This natural flavonoid effectively inhibits ClpP's hydrolytic activity towards the substrate Suc-LY-AMC with an IC50 of 49.73 μM, making it relevant for research involving Staphylococcus aureus infections. Additionally, Tamarixetin demonstrates the ability to inhibit tumor cell growth, induce apoptosis, and induce cell cycle arrest, while also preventing cardiac hypertrophy through the modulation of NFAT and AKT signaling pathways. -
Anticancer/Anti-inflammatory/Anti-diabetic Agent
Phellopterin is a furocoumarin compound recognized for its anticancer, anti-inflammatory, and anti-diabetic activities. It functions as a partial agonist of central benzodiazepine receptors and demonstrates significant anti-inflammatory properties by modulating key pathways such as SIRT1 and TLR4/NF-κB, which may aid in conditions like chronic inflammation and atopic dermatitis. Additionally, Phellopterin has been shown to inhibit ovarian cancer progression through the PU.1/CLEC5A/PI3K-AKT signaling loop and promotes adipocyte differentiation, contributing to its anti-diabetic effects. This compound is valuable for research in cancer, inflammation, diabetes management, and antiviral studies. -
Anti-neuroinflammatory Agent
2-O-Methylatromentin is an anti-neuroinflammatory agent that effectively inhibits the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, in lipopolysaccharide (LPS)-induced BV-2 microglial cells. This compound is valuable for research into neuroinflammatory diseases, providing insights into the mechanisms underlying inflammation in the central nervous system. Its efficacy in modulating inflammatory responses makes it a useful tool for investigating potential therapeutic strategies in neuroinflammatory conditions. -
Anti-inflammatory Agent
Anti-inflammatory Agent 22 is an orally active compound targeting the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production, demonstrated by an IC50 of 14.6 μM. This agent exhibits preventive effects on lymphedematous tissue by suppressing adipogenesis. Additionally, Anti-inflammatory Agent 22 has been shown to reduce limb lymphedema volume in murine models, making it a valuable tool for research into inflammatory conditions and lymphedema management. -
Anti-inflammatory Agent
Anti-inflammatory Agent 15 is a potent compound targeting inflammation through inhibition of nitric oxide synthase (iNOS). It demonstrates significant antimycobacterial activity against Mycobacterium tuberculosis strains H37Rv and M299, with MIC50 values of 2.3 μM and 7.8 μM, respectively. This agent effectively reduces pro-inflammatory cytokines TNF-α and IL-1β, making it a valuable tool for researching tuberculosis and related inflammatory pathways. -
Anti-inflammatory Agent
3-O-Caffeoyl-5-O-feruloylquinic acid is a phenolic compound with potent anti-inflammatory properties, primarily targeting free radical scavenging mechanisms. It effectively regulates inflammatory pathways by inhibiting TNF-α-induced production of reactive oxygen species (ROS) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs). This compound is valuable in research applications focused on oxidative stress and inflammation pathways, offering insights into potential therapeutic strategies for inflammatory disorders. -
Anti-inflammatory Agent
Anti-inflammatory agent 104 is a potent anti-inflammatory compound that specifically inhibits TNF-α synthesis and release in the human macrophage cell line U937, with an IC50 value of 0.024 nM. This agent demonstrates significant biological activity by reducing eosinophil levels in rat lungs by 63%, making it a valuable tool for studying inflammatory responses and evaluating therapeutic strategies in related research applications. -
Anti-inflammatory Agent
Anti-inflammatory Agent 55 is a derivative of Coixol that primarily inhibits the NF-κB signaling pathway. It effectively reduces the expression of pro-inflammatory markers such as iNOS, TNF-α, IL-6, and IL-1β. This compound significantly decreases LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 value of 0.8 μM and demonstrates noteworthy in vivo anti-inflammatory effects in a mouse auricular edema model, making it a valuable tool for research in inflammation and immune responses. -
Anti-inflammatory Agent
Siaresinolic acid is an anti-inflammatory compound derived from the leaves of Sabicea grisea. It exhibits significant antinociceptive properties by modulating ATP-dependent potassium channels and inhibiting the influx of leukocytes, plasma leakage, and the production of pro-inflammatory mediators such as TNF-α and IL-1β. Importantly, Siaresinolic acid demonstrates a lack of cytotoxicity in murine macrophages and does not affect locomotor activity even at elevated doses. This compound is suitable for research applications involving pleurisy and pain management. -
Anti-inflammatory agent
Taxamairin B is a potent anti-inflammatory agent that targets proinflammatory cytokine production. It effectively reduces the expression of TNF-α, IL-1β, and IL-6, as well as the oxidative stress markers nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW264.7 macrophage cells. Additionally, Taxamairin B demonstrates significant protective effects in models of LPS-induced acute lung injury in mice, making it a valuable compound for research on inflammatory pathways and potential therapeutic applications. -
Anti-inflammatory Agent
Oleracone is an alkaloid derived from Portulaca oleracea L. that functions as an anti-inflammatory agent. It demonstrates potent anti-inflammatory effects in the RAW 264.7 macrophage model, effectively inhibiting nitric oxide production and reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone is suitable for researching inflammatory diseases and exploring potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 54, a derivative of Coixol, targets the NF-κB signaling pathway to exert its anti-inflammatory effects. This compound effectively downregulates pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β. Notably, anti-inflammatory agent 54 inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates significant in vivo anti-inflammatory activity in a mouse model of auricular edema. -
Proinflammatory Cytokine Inhibitor
Semapimod is a potent inhibitor of proinflammatory cytokine production, targeting Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM. It effectively inhibits the production of key cytokines such as TNF-α, IL-1β, and IL-6, as well as p38 MAPK activity and nitric oxide production in macrophages. This compound holds promise for research in various inflammatory and autoimmune disorders. -
Antioxidant/Anti-inflammatory/Anti-fibrotic Agent
7-O-Galloyl-D-sedoheptulose is a polyphenolic compound recognized for its antioxidant, anti-inflammatory, and anti-fibrotic properties. It lowers serum levels of glucose, leptin, insulin, and pro-inflammatory cytokines such as TNF-α and IL-6, while increasing adiponectin levels. This compound effectively reduces reactive oxygen species (ROS) and lipid peroxidation by inhibiting the expression of NADPH oxidase components. Additionally, it down-regulates NF-κB signaling and relevant fibrotic markers, highlighting its potential applications in studying type 2 diabetes and associated complications in hepatic and pancreatic tissues. -
Anti-inflammatory Agents
CZEN-002 is a derivative of alpha-melanocyte-stimulating hormone that acts as an anti-inflammatory agent by inhibiting the production of TNF-α. It exhibits both anti-inflammatory and antibacterial properties, making it a valuable tool for researching inflammatory diseases and potential therapeutic interventions. Its mechanism of action opens avenues for studies related to immune response modulation and pathogen resistance. -
Anti-inflammatory Agent
HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 17 is a potent orally active compound that targets inflammatory pathways by inhibiting the release of pro-inflammatory cytokines IL-6 and TNF-α. In vitro studies demonstrate its ability to reduce inflammation without inducing cytotoxicity. Additionally, anti-inflammatory agent 17 exhibits significant anti-inflammatory activity in vivo, making it a valuable tool for research into acute lung injury (ALI) and other inflammatory conditions. -
Anti-inflammatory Agent
CX-659S is an orally active 5-carboxamide uracil derivative with anti-inflammatory properties. It effectively inhibits lipid peroxidation with an IC50 of 5.9 μM and reduces the infiltration of neutrophils and eosinophils. CX-659S also inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α, making it a valuable tool for research on inflammatory conditions. -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research. -
Anti-inflammatory Agent
Desoxo-narchinol A is a potent anti-inflammatory agent that is derived from the roots and rhizomes of Nardostachys jatamansi. This compound exhibits significant biological activity, making it a valuable tool for research into septic shock and various inflammatory diseases. Its oral activity further enhances its applicability in preclinical studies, providing insight into therapeutic strategies for managing inflammation-related conditions. -
Anti-inflammatory Analgesic/Anti-tumor/Diuretic Agent
Hecogenin acetate is an orally active steroid saponin aglycone that functions primarily as an anti-inflammatory and analgesic agent. It exerts its biological effects by inhibiting the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizing TRPA1/TRPM8 channels, and reducing the production of pro-inflammatory cytokines. Additionally, Hecogenin acetate demonstrates neuroprotective and anti-tumor properties, inhibits reactive oxygen species (ROS) production, and downregulates MMP-2 expression. This compound also enhances gastric mucosal defense and promotes ulcer healing while potentially restoring antibiotic sensitivity when used in combination with specific antibiotics. -
Anti-inflammatory Agent
Shizukaol B is an anti-inflammatory agent derived from the lindenane-type dimeric sesquiterpene found in Chloranthus henryi. This compound demonstrates significant inhibitory effects against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells, effectively reducing nitric oxide production and downregulating the expression of pro-inflammatory markers such as iNOS, COX-2, TNF-α, and IL-1β. Shizukaol B is suitable for research applications focused on neuroinflammation and related therapeutic strategies. -
Anti-inflammatory Agent
Chloranthalactone B is a lindenane-type sesquiterpenoid that functions as an anti-inflammatory agent. Isolated from the Chinese medicinal herb Sarcandra glabra, this compound effectively inhibits the production of inflammatory mediators by targeting the AP-1 and p38 MAPK signaling pathways. Its role in modulating inflammation makes it a valuable tool for research in inflammation-related studies and therapeutic applications. -
Anti-neuroinflammatory Agent
Grossamide is a natural compound extracted from the dried fruit of Cannabis sativa L. Its primary mechanism involves anti-neuroinflammatory activity, making it a valuable agent for research into neuroinflammatory conditions. Grossamide has potential applications in studies focused on neuroprotection and inflammation-related pathways in the nervous system. -
Anti-inflammatory Agent
EM-163 is an anti-inflammatory agent that selectively targets the TIR domain of MyD88. By intervening in the inflammatory signaling pathways, EM-163 has demonstrated efficacy in alleviating inflammation and protecting against toxic shock. This compound is particularly relevant for research related to Staphylococcal enterotoxin B (SEB) poisoning, providing a valuable tool for investigators studying inflammatory responses and potential therapeutic interventions. -
Anti-Inflammatory Agent
Skimmin, a glucoside of umbelliferone, is primarily recognized for its anti-inflammatory properties. Extracted from Hydrangea paniculata, this compound exhibits renal protective effects by enhancing creatinine clearance and mitigating kidney injury. Additionally, Skimmin demonstrates significant anti-amoebic activity against Entamoeba histolytica, as well as anti-cancer and neuroprotective effects. Its influence on cardiac health is evident through the reduction of fibrosis and the modulation of inflammatory cytokines, including TNF-α and IL-6. Skimmin serves as a valuable research tool in the study of diabetes and associated metabolic disorders. -
Anti-inflammatory Agent
1,4-Dicaffeoylquinic acid is a phenylpropanoid compound that functions as an anti-inflammatory agent through the inhibition of xanthine oxidase, with an IC50 of 7.36 μM. This compound effectively reduces inflammation by inhibiting the production of TNF-α induced by lipopolysaccharides (LPS). Its role in modulating inflammatory responses makes 1,4-Dicaffeoylquinic acid a valuable tool for research in inflammation-related studies. -
Anti-inflammatory Agent
9-Methoxycanthin-6-one, an alkaloid derived from canthin-6-one, acts as an anti-inflammatory agent. This compound demonstrates notable anti-tumor activity and effectively inhibits LPS-induced production of pro-inflammatory cytokines such as TNF-α and IL-1β. It is utilized in research applications focused on inflammation and tumor biology. -
Anti-inflammatory Agents
(±)-Perillaldehyde is an anti-inflammatory agent that demonstrates significant biological activity by inducing JNK activation in RAW264.7 cells. This compound inhibits the expression of TNF-α, with an IC50 value of 171.7 μM, highlighting its potential in modulating inflammatory responses. Additionally, (±)-Perillaldehyde exhibits antidepressant effects through its action on the olfactory nervous system, making it relevant for research into stress-related disorders. -
Anti-inflammatory Agent
7,3',4'-Tri-O-methylluteolin is a flavonoid that acts as an anti-inflammatory agent by inhibiting soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. This compound demonstrates significant anti-inflammatory effects in LPS-induced RAW 264.7 macrophages and has been shown to inhibit the MDM2-p53 binding, thereby inducing apoptosis in MCF-7 breast cancer cells. Furthermore, 7,3',4'-Tri-O-methylluteolin exhibits antioxidant, antifungal, and antitrypanosomal properties, making it valuable for various biological research applications. -
Anti-inflammatory Agent
Episappanol is a natural compound derived from the heartwood of Caesalpinia sappan, functioning primarily as an anti-inflammatory agent. It effectively inhibits the secretion of pro-inflammatory cytokines, including IL-6 and TNF-α. This compound is valuable for research applications aimed at exploring inflammation-related pathways and potential therapeutic interventions for inflammatory diseases. -
Anti-Inflammatory Agent
Kaempferol 3-O-sophoroside is an anti-inflammatory agent that functions primarily by inhibiting the toll-like receptors TLR2 and TLR4 associated with High mobility group box 1 (HMGB1). This compound displays notable anti-inflammatory and analgesic properties, primarily through the inhibition of NF-κB activation and the subsequent reduction of TNF-α production. Additionally, it promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances autophagy via AMP-activated protein kinase (AMPK) activation, contributing to its antidepressant effects. Kaempferol 3-O-sophoroside is a valuable tool for research focused on inflammation and neurodegenerative diseases. -
Anti-inflammatory Agent
Edpetiline is an anti-inflammatory agent that targets the inhibition of IκB phosphorylation, thereby preventing the nuclear translocation of NF-κB p65. This compound also inhibits p38 MAPK and ERK MAPK phosphorylation, leading to reduced intracellular ROS levels. Furthermore, Edpetiline downregulates pro-inflammatory cytokines such as TNF-α, IL-6, iNOS, and COX-2 while promoting the expression of the anti-inflammatory cytokine IL-4. It is suitable for research into conditions related to inflammation and oxidative stress. -
Anti-inflammatory Agent
Taurohyodeoxycholic acid sodium is the taurine-conjugated derivative of hyodeoxycholic acid, serving as an anti-inflammatory agent. It effectively reduces the activity and expression of myeloperoxidase, TNF-α, and IL-6, demonstrating protective effects against colonic damage in TNBS-induced ulcerative colitis models. This compound is valuable for researchers investigating inflammatory pathways and therapeutic strategies in gastrointestinal disorders. -
Proinflammatory Cytokine Inhibitor
Semapimod tetrahydrochloride is a potent inhibitor of proinflammatory cytokine production, specifically targeting tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). This compound effectively disrupts Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM, thereby inhibiting p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride holds promise for the treatment of various inflammatory and autoimmune disorders through its modulatory effects on immune responses. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
Anti-inflammatory
(2R)-Octyl-α-hydroxyglutarate sodium is the sodium salt derivative of (2R)-Octyl-α-hydroxyglutarate, functioning primarily as an anti-inflammatory agent. This compound demonstrates significant biological activity in modulating inflammatory responses, making it valuable in various research applications focused on inflammation and related pathways. -
Anti-inflammatory Agent
NPB-1575 is a potent, orally bioavailable anti-inflammatory agent that effectively targets neuroinflammation. It functions by activating the IRS2/Nrf2/NF-κB signaling axis, thereby combating ferroptosis and providing neuroprotection. NPB-1575 demonstrates efficacy in mitigating cerebral ischemic injury and enhancing neurological outcomes, making it a valuable tool for research focused on ischemic stroke and related neurodegenerative conditions. -
Anti-inflammatory Agent
Ligustrazine, an alkylpyrazine derived from Ligusticum chuanxiong, functions primarily as an anti-inflammatory agent. This compound has demonstrated notable anti-inflammatory and potential nootropic activities in preclinical studies with rat models. It is utilized in research focused on inflammatory pathways and cognitive enhancement, providing valuable insights into therapeutic applications in neuroprotection and inflammation modulation. -
Anti-inflammatory Agent
Lutein, a xanthophyll carotenoid, acts as a potent anti-inflammatory agent. It demonstrates significant biological activities, including antioxidant and anti-apoptotic effects, primarily by modulating reactive oxygen species (ROS) levels. Lutein is particularly noted for its protective benefits on ocular health and exhibits neuroprotective and antidepressant-like effects in the brain. This compound is biologically active when administered orally, making it a valuable reagent for studies in inflammation and neuroprotection. -
Non-Steroidal Anti-Inflammatory Agent
Glafenine hydrochloride is a non-selective non-steroidal anti-inflammatory agent and a dual inhibitor of COX-1 and COX-2 enzymes. It demonstrates anti-inflammatory, anti-proliferative, and anti-migratory effects by disrupting the arachidonic acid metabolic pathway and decreasing prostaglandin synthesis. This compound induces cell cycle arrest in vascular smooth muscle and endothelial cells, while also lowering Tenascin levels in the extracellular matrix. Glafenine hydrochloride is applicable in the study of inflammatory diseases, vascular restenosis, and cystic fibrosis. -
Anti-Inflammatory Agent
Proanthocyanidins are a class of polyphenolic compounds characterized by their electrophilic flavanyl units, primarily recognized for their anti-inflammatory properties. They exhibit strong antioxidant activity and have been shown to possess anticancer effects, as well as cardioprotective, antibacterial, and antifungal activities. Research applications include their potential use in treating conditions such as chronic venous insufficiency, capillary fragility, sunburn, and retinopathy. -
Anti-inflammatory Agent
Seselin is an anti-inflammatory agent that exerts its effects through multiple biological pathways. It has demonstrated potential in anticancer, antinociceptive, and antifungal activities. Seselin is suitable for research applications focused on inflammation and pain management. Its oral bioavailability enhances its utility in vivo studies.
