Fig. 1 · Structure
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Isoniazid-d4
Stable Isotope
Isoniazid-d4 is a deuterium-labeled derivative of Isoniazid, a prodrug requiring activation by the bacterial catalase-peroxidase enzyme KatG. It exhibits bactericidal activity against rapidly dividing mycobacteria, making it a critical agent in the treatment of tuberculosis. This stable isotope can be utilized in pharmacokinetic studies and tracing experiments to elucidate metabolic pathways and drug interactions within clinical and research settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 774596-24-6 |
| Applications | Stable Isotope |
| Formula | C6H3D4N3O |
| Molecular Weight | 141.16 |
| Synonyms | INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4 |
| SMILES | NNC(C1=C([2H])C([2H])=NC([2H])=C1[2H])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.