Lopinavir-d8 is a deuterated form of the potent HIV-1 protease inhibitor Lopinavir, functioning primarily by inhibiting the enzyme's activity, which is crucial for viral maturation. With an affinity (Kis) ranging from 1.3 to 3.6 pM against both wild-type and mutant strains of HIV protease, Lopinavir-d8 effectively blocks HIV-1 infectivity. Additionally, it serves as an inhibitor of SARS-CoV 3CLpro, exhibiting an IC50 value of 14.2 μM, making it valuable for research on viral proteases and potential therapeutic applications in retroviral and coronavirus research.
Lopinavir-d8 is a deuterated form of the potent HIV-1 protease inhibitor Lopinavir, functioning primarily by inhibiting the enzyme's activity, which is crucial for viral maturation. With an affinity (Kis) ranging from 1.3 to 3.6 pM against both wild-type and mutant strains of HIV protease, Lopinavir-d8 effectively blocks HIV-1 infectivity. Additionally, it serves as an inhibitor of SARS-CoV 3CLpro, exhibiting an IC50 value of 14.2 μM, making it valuable for research on viral proteases and potential therapeutic applications in retroviral and coronavirus research.
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