Pyridaben-d13 is a deuterium-labeled version of Pyridaben, a potent mitochondrial electron transport inhibitor (METI) and acaricide. This compound selectively targets complex I (NADH dehydrogenase), demonstrating an inhibitory efficacy with an IC50 value of 2.4 nM in rat liver and bovine heart mitochondria. Additionally, Pyridaben-d13 significantly affects mitochondrial nitric oxide synthase (mtNOS) function in rat models, making it a valuable reagent for studies on mitochondrial dysfunction and oxidative stress.
Pyridaben-d13 is a deuterium-labeled version of Pyridaben, a potent mitochondrial electron transport inhibitor (METI) and acaricide. This compound selectively targets complex I (NADH dehydrogenase), demonstrating an inhibitory efficacy with an IC50 value of 2.4 nM in rat liver and bovine heart mitochondria. Additionally, Pyridaben-d13 significantly affects mitochondrial nitric oxide synthase (mtNOS) function in rat models, making it a valuable reagent for studies on mitochondrial dysfunction and oxidative stress.
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