Oltipraz-d3 is a deuterium-labeled derivative of Oltipraz, primarily targeting hypoxia-inducible factor 1-alpha (HIF-1α). It demonstrates inhibitory effects on HIF-1α activation in a time-dependent manner, fully suppressing its induction at concentrations of 10 μM or greater, with an IC50 value of 10 μM. Additionally, Oltipraz acts as a potent activator of Nrf2, making it a valuable reagent for studies investigating cellular responses to hypoxic conditions and oxidative stress.
Oltipraz-d3 is a deuterium-labeled derivative of Oltipraz, primarily targeting hypoxia-inducible factor 1-alpha (HIF-1α). It demonstrates inhibitory effects on HIF-1α activation in a time-dependent manner, fully suppressing its induction at concentrations of 10 μM or greater, with an IC50 value of 10 μM. Additionally, Oltipraz acts as a potent activator of Nrf2, making it a valuable reagent for studies investigating cellular responses to hypoxic conditions and oxidative stress.
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