Rilpivirine-d6 is a deuterated form of Rilpivirine, a selective diarylpyrimidine non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV reverse transcriptase. This compound exhibits potent antiviral activity against both wild-type HIV (EC50=0.4 nM) and various mutant strains (EC50=0.1-2.0 nM). Rilpivirine demonstrates a notable genetic barrier to resistance, making it a valuable tool for research in HIV treatment and resistance profiling. Its isotopic labeling aids in pharmacokinetic and metabolic studies, enhancing understanding of drug behavior in biological systems.
Rilpivirine-d6 is a deuterated form of Rilpivirine, a selective diarylpyrimidine non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV reverse transcriptase. This compound exhibits potent antiviral activity against both wild-type HIV (EC50=0.4 nM) and various mutant strains (EC50=0.1-2.0 nM). Rilpivirine demonstrates a notable genetic barrier to resistance, making it a valuable tool for research in HIV treatment and resistance profiling. Its isotopic labeling aids in pharmacokinetic and metabolic studies, enhancing understanding of drug behavior in biological systems.
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