(rel)-Lopinavir-d8 is a deuterium-labeled derivative of Lopinavir, a selective peptidomimetic inhibitor targeting HIV-1 protease. This compound demonstrates high potency, with inhibition constants ranging from 1.3 to 3.6 pM against both wild-type and mutant forms of the enzyme, effectively hindering HIV maturation and infectivity. Additionally, (rel)-Lopinavir-d8 exhibits activity as an inhibitor of the SARS-CoV 3CLpro with an IC50 of 14.2 μM, making it a valuable tool for HIV and coronavirus research applications.
(rel)-Lopinavir-d8 is a deuterium-labeled derivative of Lopinavir, a selective peptidomimetic inhibitor targeting HIV-1 protease. This compound demonstrates high potency, with inhibition constants ranging from 1.3 to 3.6 pM against both wild-type and mutant forms of the enzyme, effectively hindering HIV maturation and infectivity. Additionally, (rel)-Lopinavir-d8 exhibits activity as an inhibitor of the SARS-CoV 3CLpro with an IC50 of 14.2 μM, making it a valuable tool for HIV and coronavirus research applications.
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