Dolutegravir-d5 is a deuterium-labeled analog of Dolutegravir, a potent inhibitor of HIV-1 integrase strand transfer. It demonstrates exceptional antiviral activity with an IC50 value of 2.7 nM against HIV-1 integrase and an IC50 of 0.51 nM for suppressing viral replication in peripheral blood mononuclear cells. Additionally, Dolutegravir maintains strong efficacy against key HIV-1 variants, including Y143R, N155H, and G140S/Q148H mutants, with EC50 values ranging from 3.6 to 5.8 nM. This stable isotope is valuable for pharmacokinetic studies and metabolic research in HIV treatment.
Dolutegravir-d5 is a deuterium-labeled analog of Dolutegravir, a potent inhibitor of HIV-1 integrase strand transfer. It demonstrates exceptional antiviral activity with an IC50 value of 2.7 nM against HIV-1 integrase and an IC50 of 0.51 nM for suppressing viral replication in peripheral blood mononuclear cells. Additionally, Dolutegravir maintains strong efficacy against key HIV-1 variants, including Y143R, N155H, and G140S/Q148H mutants, with EC50 values ranging from 3.6 to 5.8 nM. This stable isotope is valuable for pharmacokinetic studies and metabolic research in HIV treatment.
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