Escitalopram-d6 oxalate is a deuterium-labeled derivative of the selective serotonin reuptake inhibitor (SSRI) escitalopram, specifically the S-enantiomer of racemic citalopram. It demonstrates a binding affinity of 0.89 nM, approximately 30 times higher than its R(-)-enantiomer, while maintaining selectivity for serotonin transporters over dopamine (DAT) and norepinephrine (NET) transporters. This reagent is utilized in research focused on the mechanisms of major depression and the pharmacokinetics of SSRIs.
Escitalopram-d6 oxalate is a deuterium-labeled derivative of the selective serotonin reuptake inhibitor (SSRI) escitalopram, specifically the S-enantiomer of racemic citalopram. It demonstrates a binding affinity of 0.89 nM, approximately 30 times higher than its R(-)-enantiomer, while maintaining selectivity for serotonin transporters over dopamine (DAT) and norepinephrine (NET) transporters. This reagent is utilized in research focused on the mechanisms of major depression and the pharmacokinetics of SSRIs.
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