Catalog No.
Product Name
Application
Product Information
Citations
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Nonnucleoside Reverse Transcriptase Inhibitor
IQP-0528 is a potent nonnucleoside reverse transcriptase inhibitor (NNRTI) that effectively targets HIV-1 and HIV-2. It demonstrates remarkable potency with EC50 values of 0.2 nM for HIV-1 and 100 nM for HIV-2. This compound is primarily utilized in research focused on the development of antiviral therapies and the study of HIV replication mechanisms. -
HIV Inhibitor
Bz-RS-iSer(3-Ph)-OMe is a potent HIV inhibitor that specifically targets viral replication processes. This compound effectively disrupts the replication cycle of HSV with minimal cytotoxicity and inhibits mitotic divisions in Vero cells. Additionally, Bz-RS-iSer(3-Ph)-OMe influences tumor size in M-MSV models and modulates immune responses by inhibiting PHA-induced T lymphocyte proliferation, making it a valuable tool for research in virology and cancer biology. -
HIV-1 RNase H Inhibitor
HIV-1 inhibitor-45 is a potent inhibitor of the HIV-1 RNase H enzyme, demonstrating an IC50 value of 0.067 μM. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for studying viral replication and pathogenesis. However, it is characterized by low cell permeability, with an apparent permeability coefficient (Papp) of less than 0.48 × 10−6 cm/s, which may impact its effectiveness in cellular models. -
HIV-1 Reverse Transcriptase Inhibitor/μ-opioid Receptor Agonist
Corydine targets HIV-1 reverse transcriptase and the μ-opioid receptor, acting as an inhibitor with an IC50 of 356.7 μg/mL against the enzyme and an EC50 of 0.51 μM at the receptor. It exhibits antinociceptive effects through the modulation of MOR, effectively reducing acetic acid-induced writhing behavior. Corydine has also demonstrated the ability to inhibit the proliferation of various cancer cells and immune cells, making it a valuable reagent for research into HIV infection, visceral pain, and various cancers including leukemia, melanoma, bladder cancer, and colon adenocarcinoma. -
HIV-1 Capsid Protein Inhibitor
I-XW-053 is a specific inhibitor of the HIV-1 capsid protein, demonstrating antiviral activity by disrupting the interaction at the N-terminal domain interface (NTD-NTD) of the capsid protein. It effectively suppresses the replication of HIV-189BZ167 with an IC50 value of 164.2 μM. This compound serves as a valuable tool for researchers investigating HIV-1 pathogenesis and potential therapeutic approaches targeting viral replication. -
HIV-1 Nef Binder, IKZF1 Modulator
FC-14369 is a PROTAC degrader that selectively targets the HIV-1 Nef protein, exhibiting a DC50 value of 160 nM. By engaging both Nef and the Cereblon E3 ubiquitin ligase, FC-14369 facilitates the ubiquitination and subsequent proteasomal degradation of Nef, leading to the restoration of CD4 and MHC-I expression on the cell surface and effectively inhibiting HIV-1 replication. This compound is valuable for research focused on HIV infection and AIDS, advancing understanding of therapeutic strategies in viral infections. -
HIV protease Inhibitor
Telinavir is a potent and selective inhibitor of HIV protease. It effectively inhibits various strains of HIV-1, HIV-2, and simian immunodeficiency virus at EC50 values of 26 ng/mL (43 nM). With a high degree of protein binding in human plasma and minimal partitioning into erythrocytes, Telinavir serves as a valuable tool in HIV research and therapeutic development. -
Topo IIKHIV Inhibitor
2,4-Dihydroxypyridine is an effective inhibitor of Topoisomerase IIK HIV, demonstrating a pIC50 of 5.05 against this target. Additionally, it displays antiviral activity against HIV-1 replication with a pIC50 of 4.07. This compound is useful for research into HIV treatment strategies and topoisomerase mechanisms. -
SARS-CoV Inhibitor
SARS-CoV-IN-3 is a potent inhibitor of SARS-CoV replication, demonstrating anti-Coronavirus activity with an EC50 value of 3.6 μM in Vero cells. Additionally, it exhibits antimalarial properties against P. falciparum strains 3D7 and W2, with IC50 values of 11.7 nM and 20.4 nM, respectively. SARS-CoV-IN-3 also effectively mitigates HIV-1-induced cytopathic effects, yielding an EC50 of 10 μM in MT-4 cells. This compound is valuable for research in virology and parasitology. -
HIV-1 Inhibitor
Fipravirimat is a potent inhibitor of HIV-1 replication, targeting the viral protein's function. It exhibits significant antiviral activity, showing efficacy in blocking viral entry and replication. This compound is applicable for research focused on HIV and AIDS, providing valuable insights into therapeutic strategies against these infections. -
SARS-CoV Inhibitor
SARS-CoV-IN-2 is a potent inhibitor of SARS-CoV replication, demonstrating anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. Additionally, it exhibits significant inhibition of P. falciparum strains, showing IC50 values of 21.5 nM and 30 nM for the 3D7 and W2 strains, respectively. SARS-CoV-IN-2 also mitigates HIV-1-induced cytopathic effects, with an EC50 of 2.9 μM in MT-4 cells. This compound is valuable for research applications targeting both antiviral and antimalarial activities. -
HIV-1 Inhibitor
NBD-14270 is a potent HIV-1 entry antagonist that specifically targets the gp120 protein of the virus. With an IC50 of 180 nM, it exhibits significant antiviral activity against various HIV-1 Env-pseudotyped virus strains. Additionally, NBD-14270 demonstrates low cytotoxicity, with a CC50 exceeding 100 μM, making it a valuable candidate for research applications in HIV-1 inhibition. -
HIV 1 Inhibitor
HIV-1 inhibitor-8 is a potent oral non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. It demonstrates exceptional antiviral activity across various HIV-1 strains, with an EC50 range of 4.44 to 54.5 nM. Additionally, HIV-1 inhibitor-8 has an IC50 of 0.081 µM against wild-type HIV-1 reverse transcriptase, indicating its potential utility in HIV research and therapeutic applications. -
HIV-1 Reverse Transcriptase Inhibitor
Reverse transcriptase-IN-1 is a potent inhibitor of HIV-1 reverse transcriptase, classified as a diarylbenzopyrimidine (DABP) analogue. It exhibits significant antiviral activity, with effective concentration (EC50) values of 3.4 nM, 4.3 nM, and 3.6 nM against HIV-1 strains IIIB, E138K, and K103N, respectively. Additionally, it demonstrates an inhibitory concentration (IC50) of 13.7 nM on the HIV-1 reverse transcriptase enzyme, making it a valuable tool for research in HIV therapeutic development. -
Anti-HIV Agent
Nipamovir is a nitroimidazole prodrug that serves as an anti-HIV agent. It demonstrates significant antiviral activity in both cellular assays and a human ex vivo model of HIV infection, showing comparable efficacy to other reference compounds while maintaining low toxicity. Nipamovir exhibits EC50 values of 3.64±3.28 μM for CEM-SS/HIV-1RF and 3.23±2.81 μM for hPBMC/HIV-192HT599, highlighting its potential in HIV research applications. -
Non-nucleoside Reverse Transcriptase Inhibitor
Talviraline is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the HIV-1 reverse transcriptase enzyme, effectively hindering the replication of human immunodeficiency virus type 1 (HIV-1). By binding to a distinct site on the enzyme, Talviraline disrupts the viral replication process. This compound serves as a valuable tool for researching antiviral strategies and assessing the safety and efficacy of potential therapies against HIV-1 infection. -
HIV Inhibitor
3′-Azido-2′,3′-dideoxyuridine is a nucleoside analog primarily targeting human immunodeficiency virus (HIV) replication. It exhibits significant antiviral activity in human peripheral blood mononuclear cells (PBMC) while demonstrating minimal toxicity to human bone marrow cells (BMC). In addition to its role as an HIV inhibitor, 3′-Azido-2′,3′-dideoxyuridine serves as a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. -
HIV Inhibitor
Wilfortrine is a bioactive sesquiterpene alkaloid that serves as an HIV inhibitor through its immunosuppressive properties. This compound demonstrates significant anti-HIV activity, making it valuable for research focused on virology and immunology. Additionally, Wilfortrine has been shown to inhibit leukemia cell growth in murine models, indicating its potential utility in cancer research. -
HIV-1 Inhibitor
Fosdevirine serves as a potent, selective non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting human immunodeficiency virus type 1 (HIV-1). It exhibits low nanomolar activity in vitro and demonstrates efficacy against a diverse range of HIV-1 strains, including those resistant to efavirenz. This characteristic makes Fosdevirine a valuable tool for research focused on HIV-1 replication and resistance mechanisms. -
Anti-HIV-1 Agent
BNM-III-170 is a CD4-mimetic compound that acts as an anti-HIV-1 agent by targeting the Phe43 cavity of the HIV-1 gp120 envelope glycoprotein. This binding mechanism effectively inhibits the viral entry of HIV-1 into host cells. BNM-III-170 serves as a valuable tool for research focused on HIV-1 infection and potential therapeutic strategies. -
HIV Inhibitor
HIV-1 inhibitor-48 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1. This compound demonstrates significant anti-HIV-1 activity, making it a valuable tool for research focused on viral replication and treatment strategies. Its unique mechanism of action offers potential insights into the development of effective therapies for HIV-1 infections. -
HIV-1 Reverse Transcriptase Inhibitor
Atevirdine is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor that specifically targets the reverse transcriptase enzyme. By inhibiting this enzyme, Atevirdine effectively disrupts viral replication, thereby reducing HIV-1 viral load. This compound is useful in research focused on HIV-1 treatment strategies and the development of antiretroviral therapies. -
HIV-1 Inhibitor
IMB-301 is a selective inhibitor of HIV-1 replication that targets the interaction between human APOBEC3G (hA3G) and viral protein Vif. By disrupting this interaction, IMB-301 prevents Vif-mediated degradation of hA3G, a crucial restriction factor in HIV-1 replication. With an IC50 value of 8.63 µM, IMB-301 effectively inhibits HIV-1 replication in H9 cells, making it a valuable tool for studying HIV-1 biology and developing antiviral strategies. -
HIV-1 RT Inhibitor
Tenofovir diphosphate triethylamine is an inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki value of 1.55 μM for DNA and 0.022 μM for RNA. This antiretroviral compound is a valuable tool in the study of HIV replication and resistance, facilitating research into the mechanisms of AIDS pathology and treatment strategies. Its potent inhibitory activity supports the development of therapeutic approaches aimed at curbing HIV infection. -
HIV-1 Inhibitor
AzddMeC is a potent, selective nucleoside analogue that functions as an inhibitor of HIV-1 reverse transcriptase, effectively blocking HIV-1 replication. The compound demonstrates strong antiviral activity, with EC50 values of 9 nM in HIV-1-infected human peripheral blood mononuclear cells and 6 nM in HIV-1-infected human macrophages. In addition to its antiviral properties, AzddMeC serves as a versatile click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne- and DBCO- or BCN-containing molecules, respectively, making it a valuable tool in chemical biology research. -
HIV Inhibitor
Pentosan Polysulfate is an orally bioavailable sulfonated polysaccharide that acts as an HIV inhibitor by interfering with viral attachment to host cells. Its potent and selective anti-HIV activity positions it as a valuable compound for HIV research. Additionally, Pentosan Polysulfate possesses anti-inflammatory and pro-chondrogenic properties, making it relevant for studies related to interstitial cystitis. -
HIV-1 RT Inhibitor
Tenofovir diphosphate is a potent inhibitor of HIV-1 reverse transcriptase, with a Ki of 1.55 μM for DNA and 0.022 μM for RNA. This active metabolite of tenofovir demonstrates significant antiretroviral activity, making it a valuable tool for studying HIV replication and pathogenesis. Tenofovir diphosphate is utilized in research focused on AIDS and the development of effective therapies targeting HIV-1. -
HIV Replication Inhibitor
Triptonine B is a sesquiterpene pyridine alkaloid that functions as an HIV replication inhibitor. It demonstrates potent antiviral activity in H9 lymphocytes, with an EC50 value of less than 0.10 μg/mL. This compound is applicable in research focusing on HIV biology and the development of therapeutic strategies against HIV infection. -
HIV-1 Entry Inhibitor
BMS-818251 is a highly potent small-molecule inhibitor that targets HIV-1 entry, exhibiting an EC50 value of 0.019 nM. Its superior efficacy is demonstrated by over 10-fold increased potency compared to related compounds across a diverse panel of 208 HIV-1 strains. BMS-818251 enhances its inhibitory effects by interacting with conserved gp120 residues, specifically the β20-β21 hairpin, making it a valuable tool for research in HIV resistance and therapeutics. -
HIV-1 RT Inhibitor
HIV-1 inhibitor-69 is a potent inhibitor of HIV-1 reverse transcriptase (RT), a critical enzyme in the viral replication process. This compound effectively disrupts the reverse transcription of viral RNA into DNA, thereby inhibiting viral propagation. It is primarily utilized in research focused on HIV-1 pathogenesis and the development of antiretroviral therapies. -
HIV Inhibitor
12-Bromododecanoic acid is a bromo fatty acid that acts as an inhibitor of HIV replication. It has demonstrated efficacy in reducing HIV replication in CEM-SS T cells with an EC50 of 38 µM. This compound can also be utilized in the synthesis of clickable derivatives of myristic acid, highlighting its versatility in chemical research related to viral inhibition and fatty acid modification. -
HIV Inhibitor
HIV-1 Inhibitor-10 is a potent nanomolar inhibitor targeting the maturation process of HIV-1. This compound disrupts viral assembly, thereby preventing viral replication. It serves as an important research tool for studies focused on HIV biology and the development of novel therapeutic strategies against HIV-1 infections. -
Non-nucleotide HIV Reverse Transcriptase Inhibitor
Ainuovirine is a second-generation non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) that targets HIV reverse transcriptase. By non-competitively binding to the enzyme, Ainuovirine effectively disrupts the reverse transcription of viral RNA, thereby inhibiting HIV replication. This compound is utilized in research focused on human immunodeficiency virus (HIV) type 1 infection. -
HIV-1 Integrase Inhibitor
GSK3739936 is a potent allosteric inhibitor of HIV-1 integrase, exhibiting an IC50 value of 11.1 nM and an EC50 of 1.7 nM. In addition to its inhibitory effects, GSK3739936 demonstrates weak inhibition of cytochrome P450 enzymes (IC50 > 24.3 μM). This compound also showcases favorable pharmacokinetic properties in preclinical models, characterized by rapid absorption, low to moderate clearance rates, and excellent oral bioavailability, making it a promising candidate for further research in HIV therapeutics. -
HIV-1 Inhibitor
NBD-14189 is a potent HIV-1 entry antagonist that demonstrates an IC50 of 89 nM against the HIV-1 HXB2 pseudovirus. This compound targets the HIV-1 gp120 protein, effectively inhibiting viral entry and showcasing notable antiviral activity with an EC50 of less than 200 nM. NBD-14189 is suitable for research applications focusing on HIV-1 entry mechanisms and antiviral drug development. -
HIV-1 Inhibitor
HIV-1 inhibitor-33 is a highly selective inhibitor targeting HIV-1 with an EC50 value of 8.6 nM, demonstrating significant potency against viral replication. With a CC50 of 18 μM in MT-4 cells, this compound presents a favorable safety profile for research. It is suitable for studies focused on AIDS research and the development of antiviral therapies. -
HIV-1 Protease Inhibitor
DPC 684 is a highly selective HIV-1 protease inhibitor that demonstrates potent inhibitory activity with an IC90 ranging from 5.7 to 40 nM and a Ki value of 0.021 nM. By competitively inhibiting HIV-1 protease, it effectively blocks the cleavage of viral polyproteins, thereby disrupting viral replication. DPC 684 exhibits low protein binding and offers broad-spectrum inhibition against various wild-type and mutant strains of HIV-1, making it a valuable tool for research in HIV biology and therapeutic development. -
HIV-1 Inhibitor
GSK3532795 hydrochloride is a potent, orally bioavailable second-generation inhibitor targeting HIV-1 maturation. It demonstrates strong antiviral activity with EC50 values of 1.9 nM against HIV-1 wild type, 10.2 nM in human serum, and 2.7 nM and 13 nM for the HIV-1 V370A and ΔV370 variants, respectively. This compound is valuable for research applications focused on the pathogenesis and treatment of HIV-1 infections. -
HIV-1 Inhibitor
HIV-1 inhibitor-51 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1, demonstrating potent antiviral activity against both wild-type and mutant strains. It exhibits a high binding affinity with a KD of 2.50 μM and shows significant inhibitory potency with an IC50 of 0.03 μM against wild-type HIV-1 reverse transcriptase. Additionally, HIV-1 inhibitor-51 has effective EC50 values ranging from 2.22 to 53.3 nM against a range of clinically relevant mutant strains, making it a valuable tool for research in HIV-1 drug resistance and antiviral drug development. -
HIV Inhibitor
Neotripterifordin is an inhibitor of HIV replication, demonstrating significant antiviral activity. This compound exhibits an EC50 of 25 nM in H9 lymphocyte cells, indicating its potency against HIV. Neotripterifordin is valuable for research applications focused on understanding HIV pathogenesis and developing potential therapeutic strategies. -
HIV-1 Integrase Inhibitor
S 1360 is a potent and selective inhibitor of HIV-1 integrase, effectively disrupting its catalytic activity with an IC50 of 20 nM. This compound exhibits antiviral activity against both X4 and R5 tropic strains of HIV-1, including variants resistant to NRTIs, NNRTIs, and PIs. In MTT assays using HIV-1 IIIB-infected MT-4 cells, S 1360 shows an EC50 of 200 nM and a CC50 of 12 μM, making it a valuable reagent for research in HIV-1 treatment and resistance mechanisms. -
Anti-HIV Agent
KNI-102 is a potent anti-HIV agent that primarily targets HIV protease, exhibiting an IC50 value of 100 nM. This compound demonstrates significant antiviral activity, making it a valuable tool for research into HIV replication and pathogenesis. Its efficacy in inhibiting protease activity supports its application in developing novel therapeutic strategies for HIV infection. -
HIV Inhibitor
Droxinavir hydrochloride is an antiviral compound that acts as an HIV protease inhibitor. This compound significantly impedes viral replication by inhibiting the enzymatic activity essential for HIV maturation. Droxinavir hydrochloride is primarily utilized in research related to HIV infection and the development of antiviral therapies. Its role in protease inhibition makes it a valuable tool in studying HIV life cycle and resistance mechanisms. -
HIV-1 IN Chain Transfer Inhibitor
L-870810 is a potent inhibitor of HIV-1 integrase (IN) chain transfer, effectively interfering with the integration of viral DNA into the host genome. This compound exhibits significant antiviral activity, making it a valuable tool for researchers studying HIV-1 replication and potential therapeutic strategies. Its mechanism of action positions it as a key reagent for investigations into HIV-1 pathogenesis and drug development. -
HIV-1 Entry Inhibitor
RPR103611 is a derivative of betulinic acid that functions as a potent HIV-1 entry inhibitor. It displays IC50 values of 80 nM for CCR5-tropic virus YU2, 0.27 nM for CXCR4-tropic virus NL4-3, and 0.17 nM for dual tropic virus 89.6. This compound is valuable for research focused on the mechanisms of HIV-1 entry and the development of antiviral therapies. -
HIV-1 Inhibitor
HIV-1 Inhibitor-16 is a potent inhibitor targeting HIV-1 with an EC50 value of 1.3 nM against wild-type strains. This compound also demonstrates significant activity against various resistant strains, including HIV-1 K103N, E138K, Y181C, and L100I, with EC50 values of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. Its favorable solubility profile and stability in liver microsomes make it a valuable tool for research, while its minimal interaction with CYP enzymes reduces concerns regarding toxicity. This compound is ideally suited for studies focused on HIV-1 resistance and treatment strategies. -
HIV-1 Inhibitor
HIV-1 inhibitor-71 is a targeted inhibitor of HIV-1 that interferes with the transport of endocytosed HIV-1 particles into nuclear envelope invaginations (NEIs). This action effectively disrupts the viral entry process, thereby inhibiting productive infection. This compound is valuable for research applications focused on HIV-1 infection mechanisms and the development of novel antiviral strategies. -
CCR5 Antagonist
CCR5 antagonist 3 is a potent inhibitor of the CCR5 receptor, exhibiting an IC50 of 15.90 nM. This compound demonstrates broad-spectrum anti-HIV-1 activity, making it a valuable tool for research focused on HIV-1 infection mechanisms and therapeutic development. Its specificity for CCR5 enhances its potential utility in studying chemokine receptor modulation and viral entry inhibition in various biological contexts. -
HIV-1 RNase H Inhibitor
HIV-1 integrase inhibitor 9 is a potent inhibitor of HIV-1 RNase H, exhibiting an IC50 of 12.3 μM. This compound demonstrates significant antiviral activity, making it a valuable tool for research into HIV-1 replication and potential therapeutic strategies. Its role in inhibiting viral enzyme function supports the investigation of novel antiviral agents targeting HIV-1. -
HIV REV/RRE Binding Inhibitor
Fleephilone is a fungal metabolite derived from Trichoderma harzianum that acts as an HIV REV/RRE binding inhibitor. It effectively disrupts the interaction between the REV protein and RRE RNA, exhibiting an IC50 value of 7.6 μM. This compound is valuable for research focused on HIV replication mechanisms and the development of antiviral strategies targeting RNA-protein interactions.
