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LUF7996

CCR2 PROTAC Degrader

LUF7996 is a potent CCR2 PROTAC degrader that selectively targets and degrades CCR2 with a DC50 value of 2.6 μM. This compound effectively engages with the E3 ligase cereblon, promoting sustained and concentration-dependent degradation of CCR2 via the lysosomal pathway. LUF7996 is particularly valuable for research applications involving the inhibition of monocyte migration in vitro, facilitating studies in inflammation and immune response modulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3104736-80-0
Applications	CCR2 PROTAC Degrader
Formula	C₃₉H₃₄Cl₂F₃N₅O₈S
Molecular Weight	860.68
SMILES	ClC1=CC=C(OC2=CC=C(C(NCCCCCCNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)=O)C=C2)C(NS(C6=CC=C(Cl)C(C(F)(F)F)=C6)(=O)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.