Tylophorinicine is a phenanthroindolizidine alkaloid that acts primarily as an anti-fungal agent by inhibiting thymidylate synthase. It demonstrates minimum inhibitory concentrations (MIC) ranging from 2-4 mg/mL against TdnH and 0.6-2.5 mg/mL against TnnH for various Candida species. This compound is derived from Tylophora asthamatica and Pergularia pallida, positioning it as a valuable tool for researching antifungal mechanisms and therapeutic applications in fungal infections.
Tylophorinicine is a phenanthroindolizidine alkaloid that acts primarily as an anti-fungal agent by inhibiting thymidylate synthase. It demonstrates minimum inhibitory concentrations (MIC) ranging from 2-4 mg/mL against TdnH and 0.6-2.5 mg/mL against TnnH for various Candida species. This compound is derived from Tylophora asthamatica and Pergularia pallida, positioning it as a valuable tool for researching antifungal mechanisms and therapeutic applications in fungal infections.
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